L
Luigi Naldini
Researcher at Vita-Salute San Raffaele University
Publications - 370
Citations - 59320
Luigi Naldini is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Genetic enhancement & Viral vector. The author has an hindex of 108, co-authored 345 publications receiving 55080 citations. Previous affiliations of Luigi Naldini include Università telematica San Raffaele & Sangamo BioSciences.
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The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity.
Stefano Camnasio,Alessia Delli Carri,Angelo Lombardo,Iwona Grad,Caterina Mariotti,Alessia Castucci,Björn Rozell,Pietro Lo Riso,Valentina Castiglioni,Chiara Zuccato,Christelle Rochon,Yasuhiro Takashima,Giuseppe R. Diaferia,Ida Biunno,Cinzia Gellera,Marisa Jaconi,Austin Smith,Outi Hovatta,Luigi Naldini,Stefano Di Donato,Anis Feki,Elena Cattaneo +21 more
TL;DR: Stable HD-iPS cell lines are established that can be used for investigating disease mechanisms that underlie Huntington's disease, and may provide the basis for a powerful platform for drug screening and target identification in HD.
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Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells.
Michele De Palma,Eugenio Montini,Francesca Romana Santoni de Sio,Fabrizio Benedicenti,Alessandra Gentile,Enzo Medico,Luigi Naldini +6 more
TL;DR: A novel approach based on genetic trapping to rapidly score several thousand integration sites and found that MLV vectors trapped cellular promoters more efficiently than HIV vectors, indicating a strong propensity of MLV to establish transcriptional interactions with cellular promoters.
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Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia.
Sarah Marktel,Samantha Scaramuzza,Maria Pia Cicalese,Fabio Giglio,Stefania Galimberti,Maria Rosa Lidonnici,Valeria Calbi,Andrea Assanelli,Maria Ester Bernardo,Claudia Rossi,Andrea Calabria,Raffaella Milani,Salvatore Gattillo,Fabrizio Benedicenti,Giulio Spinozzi,Annamaria Aprile,Alessandra Bergami,Miriam Casiraghi,Giulia Consiglieri,Nicoletta Masera,Emanuela D'Angelo,Nadia Mirra,Raffaella Origa,Immacolata Tartaglione,Silverio Perrotta,Robert Winter,Milena Coppola,Gianluca Viarengo,Luca Santoleri,Giovanna Graziadei,Michela Gabaldo,Maria Grazia Valsecchi,Eugenio Montini,Luigi Naldini,Maria Domenica Cappellini,Fabio Ciceri,Alessandro Aiuti,Giuliana Ferrari +37 more
TL;DR: In a phase 1/2 clinical trial, gene therapy with autologous hematopoietic stem cells significantly reduced transfusion requirement in adults and children with transfusion dependent ß-thalassemia.
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Tie2 identifies a hematopoietic monocytes required for tumor lineage of proangiogenic vessel formation and a mesenchymal population of pericyte progenitors
M. De Palma,Mary Anna Venneri,Rossella Galli,Lucia Sergi Sergi,Letterio S. Politi,Maurilio Sampaolesi,Luigi Naldini +6 more
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A New-Generation Stable Inducible Packaging Cell Line for Lentiviral Vectors
Deborah Farson,Rochelle Witt,Ryan Mcguinness,Tom Dull,Michael C. Kelly,Jin-Ping Song,Robert Radeke,Anatoly Bukovsky,Antonella Consiglio,Luigi Naldini +9 more
TL;DR: The packaging cell line and all vector producer clones described here were shown to be free from replication-competent recombinants, and from recombinant between packaging and vector constructs that transfer the viral gag-pol genes.