L
Luigi Naldini
Researcher at Vita-Salute San Raffaele University
Publications - 370
Citations - 59320
Luigi Naldini is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Genetic enhancement & Viral vector. The author has an hindex of 108, co-authored 345 publications receiving 55080 citations. Previous affiliations of Luigi Naldini include Università telematica San Raffaele & Sangamo BioSciences.
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Journal ArticleDOI
Lentiviral Vector Gene Transfer Is Limited by the Proteasome at Postentry Steps in Various Types of Stem Cells
Francesca Romana Santoni de Sio,Francesca Romana Santoni de Sio,Angela Gritti,Paolo Cascio,Margherita Neri,Maurilio Sampaolesi,Cesare Galli,Jeremy Luban,Luigi Naldini,Luigi Naldini +9 more
TL;DR: The proteasome limits lentiviral gene transfer in all stem cell types tested, including embryonic, mesenchymal, and neural, of both human and mouse origin, suggesting that it represents a novel feature of the stem cell/immature progenitor phenotype.
Journal ArticleDOI
Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells
Francesco Piras,Michela Riba,Carolina Petrillo,Dejan Lazarevic,Ivan Cuccovillo,Sara Bartolaccini,Elia Stupka,Bernhard Gentner,Davide Cittaro,Luigi Naldini,Anna Kajaste-Rudnitski +10 more
TL;DR: A remarkably limited impact of LV on the HSPC transcriptional landscape is unraveled and blocking LV‐induced signaling partially rescued both apoptosis and engraftment, highlighting a novel strategy to further dampen the impact of ex vivo gene transfer on HspC.
Journal ArticleDOI
Lentiviral haematopoietic stem-cell gene therapy for early-onset metachromatic leukodystrophy: long-term results from a non-randomised, open-label, phase 1/2 trial and expanded access
Francesca Fumagalli,Valeria Calbi,Maria Grazia Natali Sora,Maria Sessa,Cristina Baldoli,Paola M.V. Rancoita,Francesca Ciotti,Marina Sarzana,M. Fraschini,Alberto Zambon,Serena Acquati,Daniela Redaelli,Vanessa Attanasio,Simona Miglietta,Fabiola De Mattia,Federica Barzaghi,Francesca Ferrua,Maddalena Migliavacca,Francesca Tucci,Vera Gallo,Ubaldo Del Carro,Sabrina Canale,Ivana Spiga,Laura Lorioli,Salvatore Marco Recupero,Elena Fratini,Francesco Morena,Paolo Silvani,Maria Rosa Calvi,Marcella Facchini,S Locatelli,Ambra Corti,S Zancan,Gigliola Antonioli,Giada Farinelli,Michela Gabaldo,J García-Segovia,Laetitia C Schwab,Gerald Downey,M. Filippi,Maria Pia Cicalese,Sabata Martino,Clelia Di Serio,Fabio Ciceri,Maria Ester Bernardo,Luigi Naldini,Alessandra Biffi,Alessandro Aiuti +47 more
TL;DR: Treatment with arsa-cel resulted in sustained, clinically relevant benefits in children with early-onset MLD by preserving cognitive function and motor development in most patients, and slowing demyelination and brain atrophy.
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Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors
Rohit Sachdeva,Marie E. Jönsson,Jenny Nelander,Agnete Kirkeby,Carolina Guibentif,Bernhard Gentner,Luigi Naldini,Anders Björklund,Malin Parmar,Johan Jakobsson +9 more
TL;DR: A microRNA-regulated lentiviral reporter system was used to visualize and segregate differentiating neuronal cells in pluripotent cultures and track progeny from murine ES, human ES cells, and induced plurIPotent stem cells as they differentiated toward the neural lineage.
Journal ArticleDOI
Pervasive supply of therapeutic lysosomal enzymes in the CNS of normal and Krabbe-affected non-human primates by intracerebral lentiviral gene therapy.
Vasco Meneghini,Annalisa Lattanzi,Luigi Tiradani,Gabriele Bravo,Francesco Morena,Francesca Sanvito,Andrea Calabria,John Bringas,Jeanne M. Fisher-Perkins,Jason Dufour,Kate C. Baker,Claudio Doglioni,Eugenio Montini,Bruce A. Bunnell,Krystof S. Bankiewicz,Sabata Martino,Luigi Naldini,Angela Gritti +17 more
TL;DR: The rationale for the clinical translation of intracerebral lentiviral GT to address CNS pathology in MLD, GLD, and other neurodegenerative LSD supports the robustness of the proposed GT platform.