L
Luigi Naldini
Researcher at Vita-Salute San Raffaele University
Publications - 370
Citations - 59320
Luigi Naldini is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Genetic enhancement & Viral vector. The author has an hindex of 108, co-authored 345 publications receiving 55080 citations. Previous affiliations of Luigi Naldini include Università telematica San Raffaele & Sangamo BioSciences.
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Journal ArticleDOI
Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells.
TL;DR: TEM cells may account for the proangiogenic activity of bone marrow–derived cells in tumors, may represent a new target for drug development and may provide the means for selective gene delivery and targeted inhibition of tumor angiogenesis.
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Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells
Roberta Mazzieri,Ferdinando Pucci,Davide Moi,Erika Zonari,Anna Ranghetti,Alvise Berti,Letterio S. Politi,Bernhard Gentner,Jeffrey L. Brown,Luigi Naldini,Michele De Palma +10 more
TL;DR: Blocking angiopoietin-2 (ANG2), a TIE2 ligand and angiogenic factor expressed by activated endothelial cells (ECs), regresses the tumor vasculature and inhibits progression of late-stage, metastatic MMTV-PyMT mammary carcinomas and RIP1-Tag2 pancreatic insulinomas.
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Cleavage of the Plasma Membrane Na+/Ca2+ Exchanger in Excitotoxicity
Daniele Bano,Kenneth W. Young,Christopher J. Guerin,Ros LeFeuvre,Nancy J. Rothwell,Luigi Naldini,Rosario Rizzuto,Ernesto Carafoli,Pierluigi Nicotera +8 more
TL;DR: It is reported that the major plasma membrane Ca2+ extruding system, the Na+/Ca2+ exchanger (NCX), is cleaved during brain ischemia and in neurons undergoing excitotoxicity, and proteolytic inactivation of NCX-driven neuronal Ca 2+ extrusion is responsible for the delayedexcitotoxic Ca2+, deregulation and neuronal death.
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Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer
TL;DR: This expression profile enabled stable gene transfer in immunocompetent mice, thus overcoming a major hurdle to successful gene therapy and demonstrating a new paradigm in vector design with applications for genetic engineering and therapeutic gene transfer.
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Targeted genome editing in human repopulating haematopoietic stem cells
Pietro Genovese,Giulia Schiroli,Giulia Escobar,Tiziano Di Tomaso,Claudia Firrito,Andrea Calabria,Davide Moi,Roberta Mazzieri,Chiara Bonini,Michael C. Holmes,Philip D. Gregory,Mirjam van der Burg,Bernhard Gentner,Eugenio Montini,Angelo Lombardo,Luigi Naldini +15 more
TL;DR: Gene-edited HSCs sustained normal haematopoiesis and gave rise to functional lymphoid cells that possess a selective growth advantage over those carrying disruptive IL2RG mutations, which opens up new avenues for treating SCID-X1 and other diseases.