L
Luigi Naldini
Researcher at Vita-Salute San Raffaele University
Publications - 370
Citations - 59320
Luigi Naldini is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Genetic enhancement & Viral vector. The author has an hindex of 108, co-authored 345 publications receiving 55080 citations. Previous affiliations of Luigi Naldini include Università telematica San Raffaele & Sangamo BioSciences.
Papers
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Journal ArticleDOI
Targeting the tumor and its microenvironment by a dual-function decoy Met receptor.
Paolo Michieli,Massimiliano Mazzone,Cristina Basilico,Silvia Cavassa,Antonino Sottile,Luigi Naldini,Paolo M. Comoglio +6 more
TL;DR: Evidence is provided that in vivo expression of decoy Met inhibits tumor cell proliferation and survival in a variety of human xenografts, impairs tumor angiogenesis by preventing host vessel arborization, and synergizes with radiotherapy in inducing tumor regression, without affecting housekeeping physiological functions in the adult animal.
Patent
Method and means for producing high titer, safe, recombinant lentivirus vectors
TL;DR: In the absence of a functional tat gene, the vector carrying the transgene enhances virus production as discussed by the authors, which is useful in the production of recombinant lentivirus vectors.
Journal ArticleDOI
RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP.
Giovanni Gaudino,Antonia Follenzi,Luigi Naldini,Chiara Collesi,Massimo Santoro,Kathleen A. Gallo,Paul J. Godowski,Paolo M. Comoglio +7 more
TL;DR: The data show that p185RON is a tyrosine kinase activated by MSP and that it is member of a family of growth factor receptors with distinct specificities for structurally related ligands.
Journal ArticleDOI
Site-specific integration and tailoring of cassette design for sustainable gene transfer.
Angelo Lombardo,Daniela Cesana,Pietro Genovese,Bruno Di Stefano,Elena Provasi,Daniele F Colombo,Margherita Neri,Zulma Magnani,Alessio Cantore,Pietro Lo Riso,Martina Damo,Oscar M Pello,Michael C. Holmes,Philip D. Gregory,Angela Gritti,Vania Broccoli,Chiara Bonini,Luigi Naldini +17 more
TL;DR: A framework for sustainable gene transfer in AAVS1 is provided that can be used for dependable genetic manipulation, neutral marking of the cell and improved safety of therapeutic applications, and demonstrate its feasibility by rapidly generating human lymphocytes and stem cells carrying targeted and benign transgene insertions.
Journal ArticleDOI
CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma
Monica Casucci,Benedetta Nicolis di Robilant,Laura Falcone,Barbara Camisa,Margherita Norelli,Pietro Genovese,Bernhard Gentner,Fabiana Gullotta,Maurilio Ponzoni,Massimo Bernardi,Magda Marcatti,Aurore Saudemont,Claudio Bordignon,Claudio Bordignon,Barbara Savoldo,Fabio Ciceri,Luigi Naldini,Gianpietro Dotti,Chiara Bonini,Attilio Bondanza +19 more
TL;DR: In this paper, suicidal CD44v6-targeted T cells were found to have potent antitumor effects against primary AML and multiple myeloma (MM) cells in immunocompromised mice.