L
Luigi Naldini
Researcher at Vita-Salute San Raffaele University
Publications - 370
Citations - 59320
Luigi Naldini is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Genetic enhancement & Viral vector. The author has an hindex of 108, co-authored 345 publications receiving 55080 citations. Previous affiliations of Luigi Naldini include Università telematica San Raffaele & Sangamo BioSciences.
Papers
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Journal ArticleDOI
Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
Giulia Escobar,Luigi Barbarossa,Giulia Barbiera,Margherita Norelli,Marco Genua,Anna Ranghetti,Tiziana Plati,Barbara Camisa,Chiara Brombin,Davide Cittaro,Andrea Annoni,Attilio Bondanza,Renato Ostuni,Bernhard Gentner,Luigi Naldini +14 more
TL;DR: In this article, the authors showed that monocyte-mediated gene delivery of IFNα inhibits leukemia in a mouse model and enhances anti-tumor activity of adoptively transferred T cells engineered with tumor-specific TCR or CAR.
Journal ArticleDOI
Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich syndrome
Marita Bosticardo,Elena Draghici,Francesca Schena,Aisha V. Sauer,Elena Fontana,Maria Carmina Castiello,Marco Catucci,Michela Locci,Luigi Naldini,Alessandro Aiuti,Maria Grazia Roncarolo,Pietro Luigi Poliani,Elisabetta Traggiai,Anna Villa +13 more
TL;DR: Wiskott-Aldrich syndrome gene therapy leads to improvement of B-cell functions, even in the presence of a mixed chimerism, further validating the clinical application of the w1.6W lentiviral vector.
Journal ArticleDOI
Deletion in a (T)8 microsatellite abrogates expression regulation by 3′‐UTR
Tina Ruggiero,Martina Olivero,Antonia Follenzi,Luigi Naldini,Raffaele A. Calogero,Maria Flavia Di Renzo +5 more
TL;DR: Data show that CEACAM1 3'-UTR contains non-canonical elements contributing to mRNA regulation, among which a short repeat sequence could play a critical regulatory function, suggesting that, in cancer cells, a single mutation in a 3'-utR short microsatellite might strongly affect gene expression.
Patent
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
TL;DR: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell as discussed by the authors, and is related to our work.
Journal ArticleDOI
Preclinical Testing of the Safety and Tolerability of Lentiviral Vector-Mediated Above-Normal Alpha-L-Iduronidase Expression in Murine and Human Hematopoietic Cells Using Toxicology and Biodistribution Good Laboratory Practice Studies.
Ilaria Visigalli,Stefania Delai,Francesca Ferro,Francesca Cecere,Michela Vezzoli,Francesca Sanvito,Franck Chanut,Fabrizio Benedicenti,Giulio Spinozzi,Rob Wynn,Andrea Calabria,Luigi Naldini,Eugenio Montini,Patrizia Cristofori,Alessandra Biffi +14 more
TL;DR: Biosafety studies were conducted to assess the toxicity and tumorigenic potential, as well as the biodistribution of HSCs and progenitor cells transduced with lentiviral vectors encoding the cDNA of the alpha-iduronidase (IDUA) gene, which is mutated in MPS I patients.