L
Luigi Naldini
Researcher at Vita-Salute San Raffaele University
Publications - 370
Citations - 59320
Luigi Naldini is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Genetic enhancement & Viral vector. The author has an hindex of 108, co-authored 345 publications receiving 55080 citations. Previous affiliations of Luigi Naldini include Università telematica San Raffaele & Sangamo BioSciences.
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Vector and method of use for nucleic acid delivery to non-dividing cells
TL;DR: A recombinant retrovirus capable of infecting a non-dividing cell and a method of producing such a virus is provided in this article, which is useful for the treatment of a variety of disorders.
Journal ArticleDOI
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
Elena Provasi,Pietro Genovese,Angelo Lombardo,Zulma Magnani,Pei-Qi Liu,Andreas Reik,Victoria Chu,David Paschon,Lei Zhang,Jürgen Kuball,Barbara Camisa,Attilio Bondanza,Giulia Casorati,Maurilio Ponzoni,Fabio Ciceri,Claudio Bordignon,Philip D. Greenberg,Michael C. Holmes,Philip D. Gregory,Luigi Naldini,Chiara Bonini +20 more
TL;DR: The TCR-edited lymphocytes did not mediate off-target reactivity while maintaining their anti-tumor activity in vivo, thus showing that complete editing of T cell specificity generates tumor-specific lymphocytes with improved biosafety profiles.
Journal ArticleDOI
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Marie Carlén,Marie Carlén,Konstantinos Meletis,Konstantinos Meletis,Christian Göritz,Vladimer Darsalia,Emma Evergren,Kenji Tanigaki,Mario Amendola,Fanie Barnabé-Heider,Maggie S. Y. Yeung,Luigi Naldini,Tasuku Honjo,Zaal Kokaia,Oleg Shupliakov,Robert Cassidy,Olle Lindvall,Jonas Frisén +17 more
TL;DR: Although ependymal cells act as primary cells in the neural lineage to produce neurons and glial cells after stroke, they do not fulfill defining criteria for stem cells under these conditions and instead serve as a reservoir that is recruited by injury.
Journal ArticleDOI
Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: Implications for myocardium regeneration
Gianluigi Condorelli,Ugo Borello,L. De Angelis,Michael V.G. Latronico,Dario Sirabella,M. Coletta,Rossella Galli,Giovanna Balconi,Antonia Follenzi,Giacomo Frati,M. G. Cusella De Angelis,L. Gioglio,S. Amuchastegui,Luciano Adorini,Luigi Naldini,Angelo L. Vescovi,Elisabetta Dejana,Giulio Cossu +17 more
TL;DR: It is reported that endothelial cells, either freshly isolated from embryonic vessels or established as homogenous cells in culture, differentiate into beating cardiomyocytes and express cardiac markers when cocultured with neonatal rat cardiomeocytes or when injected into postischemic adult mouse heart.
Journal ArticleDOI
Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications
Brian D. Brown,Luigi Naldini +1 more
TL;DR: The benefits of using artificial microRNA target sites to exploit or inhibit endogenous miRNA regulation for gene and stem cell therapy studies and for animal transgenics are considered.