L
Luigi Naldini
Researcher at Vita-Salute San Raffaele University
Publications - 370
Citations - 59320
Luigi Naldini is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Genetic enhancement & Viral vector. The author has an hindex of 108, co-authored 345 publications receiving 55080 citations. Previous affiliations of Luigi Naldini include Università telematica San Raffaele & Sangamo BioSciences.
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Journal ArticleDOI
Lentiviral gene transfer and ex vivo expansion of human primitive stem cells capable of primary, secondary, and tertiary multilineage repopulation in NOD/SCID mice
Wanda Piacibello,Stefania Bruno,Fiorella Sanavio,Sara Droetto,Monica Gunetti,Laurie Ailles,Francesca R. Santoni de Sio,Andrea Viale,Loretta Gammaitoni,Angelo Lombardo,Luigi Naldini,Massimo Aglietta +11 more
TL;DR: Results show that lentiviral vectors efficiently transduce HSCs, which can undergo expansion and maintain proliferation and self-renewal ability.
Journal ArticleDOI
ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.
Robin Lovell-Badge,Eric Anthony,Roger A. Barker,Tania Bubela,Ali H. Brivanlou,Melissa K. Carpenter,R. Alta Charo,Amander T. Clark,Ellen Wright Clayton,Yali Cong,George Q. Daley,Jianping Fu,Misao Fujita,Andy Greenfield,Steve A. Goldman,Steve A. Goldman,Lori R. Hill,Insoo Hyun,Insoo Hyun,Rosario Isasi,Jeffrey P. Kahn,Kazuto Kato,Jin-Soo Kim,Jonathan Kimmelman,Jürgen A. Knoblich,Debra J. H. Mathews,Nuria Montserrat,Jack Mosher,Megan Munsie,Hiromitsu Nakauchi,Hiromitsu Nakauchi,Luigi Naldini,Gail Naughton,Kathy K. Niakan,Kathy K. Niakan,Ubaka Ogbogu,Roger A. Pedersen,Nicolas C. Rivron,Heather M. Rooke,Janet Rossant,Jeff Round,Mitinori Saitou,Douglas Sipp,Julie Steffann,Jeremy Sugarman,Azim Surani,Jun Takahashi,Fuchou Tang,Leigh Turner,Patricia J. Zettler,Xiaomei Zhai +50 more
TL;DR: The International Society for Stem Cell Research (ISCR) as discussed by the authors updated its guidelines for stem cell research and clinical translation in order to address advances in stem cell science and other relevant fields, together with the associated ethical, social, and policy issues that have arisen since the last update in 2016.
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Angiopoietin-2 TIEs up macrophages in tumor angiogenesis
Michele De Palma,Luigi Naldini +1 more
TL;DR: The clinical opportunities afforded by simultaneously targeting the effects of ANG2 on tumor angiogenesis and the proangiogenic activity of TEMs are discussed.
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Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects
Alessandra Mortellaro,Raisa Jofra Hernandez,Matteo M. Guerrini,Filippo Carlucci,Antonella Tabucchi,Maurilio Ponzoni,Francesca Sanvito,Claudio Doglioni,Clelia Di Serio,Luca Biasco,Antonia Follenzi,Luigi Naldini,Claudio Bordignon,Maria Grazia Roncarolo,Alessandro Aiuti +14 more
TL;DR: The efficacy of LV gene transfer in correcting both the immunological and metabolic phenotypes of ADA-SCID is demonstrated and supports the future clinical use of this approach.
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Lentiviral vector–based insertional mutagenesis identifies genes associated with liver cancer
Marco Ranzani,Daniela Cesana,Cynthia C. Bartholomae,Francesca Sanvito,Mauro Pala,Fabrizio Benedicenti,Pierangela Gallina,Lucia Sergi Sergi,Stefania Merella,Alessandro Bulfone,Claudio Doglioni,Christof von Kalle,Yoon Jun Kim,Manfred Schmidt,Giovanni Tonon,Luigi Naldini,Eugenio Montini +16 more
TL;DR: An insertional mutagenesis platform based on lentiviral vectors by which four previously unknown liver cancer–associated genes are identified from a limited number of integrations and validated the oncogenic potential of all the identified genes in vivo.