L
Luigi Naldini
Researcher at Vita-Salute San Raffaele University
Publications - 370
Citations - 59320
Luigi Naldini is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Genetic enhancement & Viral vector. The author has an hindex of 108, co-authored 345 publications receiving 55080 citations. Previous affiliations of Luigi Naldini include Università telematica San Raffaele & Sangamo BioSciences.
Papers
More filters
Journal ArticleDOI
Tumor-Targeted Interferon-α Delivery by Tie2-Expressing Monocytes Inhibits Tumor Growth and Metastasis
Michele De Palma,Roberta Mazzieri,Letterio S. Politi,Ferdinando Pucci,Erika Zonari,Giovanni Sitia,Stefania Mazzoleni,Davide Moi,Mary Anna Venneri,Stefano Indraccolo,Andrea Falini,Luca G. Guidotti,Rossella Galli,Luigi Naldini +13 more
TL;DR: This work exploited the tumor-homing ability of proangiogenic Tie2-expressing monocytes (TEMs) to deliver IFN-alpha to tumors and obtained significant antitumor responses and near complete abrogation of metastasis.
Journal ArticleDOI
Lentiviral vectors containing the human immunodeficiency virus type-1 central polypurine tract can efficiently transduce nondividing hepatocytes and antigen-presenting cells in vivo
Thierry VandenDriessche,Lieven Thorrez,Luigi Naldini,Antonia Follenzi,Lieve Moons,Zwi N. Berneman,Desire Collen,Marinee Chuah +7 more
TL;DR: Potential uses of improved lentiviral vectors for gene therapy of genetic blood disorders resulting from serum protein deficiencies, such as hemophilia, and hepatic disease are suggested and the use of liver-specific promoters may be warranted to circumvent inadvertent transgene expression in APCs.
Journal ArticleDOI
Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors.
TL;DR: It is shown that rat hepatocytes were transduced ex vivo to high frequency without requirement for proliferation, indicating the potential efficacy of improved lentiviral vectors for the gene therapy of hemophilias and other diseases.
Journal ArticleDOI
Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction.
Luigi Naldini,Elisa Vigna,Alberto Bardelli,Antonia Follenzi,Francesco Galimi,Paolo M. Comoglio +5 more
TL;DR: The stoichiometry of the activation reaction suggests that the biological effects of HGF can be titrated in vivo by the level of uPA activity, which would condition the tissue microenvironment by rendering HGF bioavailable to its target cells.
Journal ArticleDOI
The MET oncogene drives a genetic programme linking cancer to haemostasis.
Carla Boccaccio,Gabriella Sabatino,Enzo Medico,Flavia Girolami,Antonia Follenzi,Gigliola Reato,Antonino Sottile,Luigi Naldini,Paolo M. Comoglio +8 more
TL;DR: In vivo analysis showed that both proteins support the thrombohaemorrhagic phenotype, thus providing direct genetic evidence for the long-sought-after link between oncogene activation and haemostasis.