M
Marcelo J. Kuroda
Researcher at Beth Israel Deaconess Medical Center
Publications - 49
Citations - 8469
Marcelo J. Kuroda is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Simian immunodeficiency virus & CTL*. The author has an hindex of 33, co-authored 48 publications receiving 8381 citations.
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Journal ArticleDOI
Control of Viremia in Simian Immunodeficiency Virus Infection by CD8+ Lymphocytes
Jörn E. Schmitz,Marcelo J. Kuroda,Sampa Santra,Vito G. Sasseville,Meredith A. Simon,Michelle A. Lifton,Paul Racz,Klara Tenner-Racz,Margaret Dalesandro,Bernhard J. Scallon,John Ghrayeb,Meryl A. Forman,David C. Montefiori,E. Peter Rieber,Norman L. Letvin,Keith A. Reimann +15 more
TL;DR: The results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.
Journal ArticleDOI
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity.
John W. Shiver,Tong-Ming Fu,Ling Chen,Danilo R. Casimiro,Mary-Ellen Davies,Robert K. Evans,Zhiqiang Zhang,Adam J. Simon,Wendy L. Trigona,Sheri Dubey,Lingyi Huang,Virginia Harris,Romnie Long,Xiaoping Liang,Larry Handt,William A. Schleif,Lan Zhu,Daniel C. Freed,Natasha Persaud,Liming Guan,Kara Punt,Aimin Tang,Minchun Chen,Keith A. Wilson,Kelly B. Collins,Gwendolyn J. Heidecker,V. Rose Fernandez,Helen C. Perry,Joseph G. Joyce,Karen M. Grimm,James C. Cook,Paul M. Keller,Denise S. Kresock,Henryk Mach,Robert D. Troutman,Lynne Isopi,Donna M. Williams,Zheng Xu,Kathryn E. Bohannon,David B. Volkin,David C. Montefiori,Ayako Miura,Georgia R. Krivulka,Michelle A. Lifton,Marcelo J. Kuroda,Jörn E. Schmitz,Norman L. Letvin,Michael J. Caulfield,Andrew J. Bett,Rima Youil,David C. Kaslow,Emilio A. Emini +51 more
TL;DR: The replication-defective adenovirus is a promising vaccine vector for development of an HIV-1 vaccine and elicited by a replication-incompetent Ad5 vector, used either alone or as a booster inoculation after priming with a DNA vector.
Journal ArticleDOI
Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination
Dan H. Barouch,Sampa Santra,Jörn E. Schmitz,Marcelo J. Kuroda,Tong-Ming Fu,Wendeline Wagner,Miroslawa Bilska,Abie Craiu,Xin Xiao Zheng,Georgia R. Krivulka,Kristin Beaudry,Michelle A. Lifton,Christine E. Nickerson,Wendy L. Trigona,Kara Punt,Dan C. Freed,Liming Guan,Sheri Dubey,Danilo R. Casimiro,Adam J. Simon,Mary-Ellen Davies,Michael Chastain,Terry B. Strom,Rebecca Gelman,David C. Montefiori,Mark G. Lewis,Emilio A. Emini,John W. Shiver,Norman L. Letvin +28 more
TL;DR: The protective efficacy of vaccine-elicited immune responses against a pathogenic SHIV-89.6P challenge in rhesus monkeys is reported, with no evidence of clinical disease or mortality after challenge.
Journal ArticleDOI
Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
Dan H. Barouch,Jennifer Kunstman,Marcelo J. Kuroda,Jörn E. Schmitz,Sampa Santra,Fred W. Peyerl,Georgia R. Krivulka,Kristin Beaudry,Michelle A. Lifton,Darci A. Gorgone,David C. Montefiori,Mark G. Lewis,Steven M. Wolinsky,Norman L. Letvin +13 more
TL;DR: Viral escape from CTL recognition may be a major limitation of the CTL-based AIDS vaccines that are likely to be administered to large human populations over the next several years.
Journal ArticleDOI
Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex.
Marcelo J. Kuroda,Jörn E. Schmitz,Dan H. Barouch,Abie Craiu,Todd M. Allen,A Sette,David I. Watkins,Meryl A. Forman,Norman L. Letvin +8 more
TL;DR: The power of this approach for examining virus-specific CTLs in in vivo settings is indicated and phenotypic characterization of the cells binding this tetrameric complex indicated that this lymphocyte population is heterogeneous.