Margarete A. Fabre

TL;DR: The authors analyzed genetic data from 200,453 UK Biobank participants to map the landscape of inherited predisposition to CH, increasing the number of germline associations with CH in European-ancestry populations from 4 to 14.

TL;DR: It is concluded that when azathioprine is administered at an initial dose of 1.5 mg/kg per day, both coding and promoter TPMT polymorphisms influence the dose tolerated.

TL;DR: The venetoclax-gilteritinib combination merits testing as potentially active regimen in high-risk AML patients with FLT3 wildtype by inducing MCL-1 degradation.

TL;DR: In this paper , the authors found that chronic poor sleep is a causal risk factor for contracting respiratory infections and in addition contributes to the severity of respiratory infections, and they used logistic regression to assess association between poor sleep and infections, disease free survival hazard ratios, and used summary statistics from genomewide association studies of insomnia, influenza, URI and COVID-19 to perform Mendelian randomization analyses and assess causality.