M
Markus R. Wenk
Researcher at National University of Singapore
Publications - 332
Citations - 25285
Markus R. Wenk is an academic researcher from National University of Singapore. The author has contributed to research in topics: Medicine & Lipid metabolism. The author has an hindex of 81, co-authored 292 publications receiving 21516 citations. Previous affiliations of Markus R. Wenk include Swiss Tropical and Public Health Institute & University of Geneva.
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Journal ArticleDOI
The emerging field of lipidomics
TL;DR: Novel analytical approaches — in particular, liquid chromatography and mass spectrometry — for systems-level analysis of lipids and their interacting partners (lipidomics) now make this field a promising area of biomedical research, with a variety of applications in drug and biomarker development.
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Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase
You-Tong Wu,Hui-Ling Tan,Guanghou Shui,Chantal Bauvy,Qing Huang,Markus R. Wenk,Choon Nam Ong,Patrice Codogno,Han-Ming Shen,Han-Ming Shen +9 more
TL;DR: To their surprise, 3-MA is found to promote autophagy flux when treated under nutrient-rich conditions with a prolonged period of treatment, whereas it is still capable of suppressing starvation-induced autophagosomes or lysosomal function.
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Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling
Ottavio Cremona,Ottavio Cremona,Gilbert Di Paolo,Markus R. Wenk,Anita Lüthi,Warren T. Kim,Kohji Takei,Laurie Daniell,Yasuo Nemoto,Stephen B. Shears,Richard A. Flavell,David A. McCormick,Pietro De Camilli +12 more
TL;DR: It is reported here that synaptojanin 1-deficient mice exhibit neurological defects and die shortly after birth, providing genetic evidence for a crucial role of phosphoinositide metabolism in synaptic vesicle recycling.
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Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
Long N. Nguyen,Dongliang Ma,Guanghou Shui,Peiyan Wong,Amaury Cazenave-Gassiot,Xiao-Dong Zhang,Markus R. Wenk,Eyleen L. K. Goh,David L. Silver +8 more
TL;DR: This work identifies a member of the major facilitator superfamily—Mfsd2a (previously an orphan transporter)—as the major transporter for DHA uptake into brain and reveals an unexpected essential physiological role of plasma-derived LPCs in brain growth and function.
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Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.
William L. Holland,Benjamin T. Bikman,Liping Wang,Guan Yuguang,Katherine M. Sargent,Sarada Bulchand,Trina A. Knotts,Guanghou Shui,Deborah J. Clegg,Markus R. Wenk,Michael J. Pagliassotti,Philipp E. Scherer,Scott A. Summers,Scott A. Summers,Scott A. Summers +14 more
TL;DR: It is shown here that TLR4 is an upstream signaling component required for saturated fatty acid-induced ceramide biosynthesis, and that sphingolipids such as ceramide might be key components of the signaling networks that link lipid-induced inflammatory pathways to the antagonism of insulin action that contributes to diabetes.