Humoral Immune Response to SARS-CoV-2 in Iceland.
Daniel F. Gudbjartsson,Gudmundur L. Norddahl,Páll Melsted,Kristbjorg Gunnarsdottir,Hilma Holm,Elias Eythorsson,Asgeir O. Arnthorsson,Dadi Helgason,Kristbjorg Bjarnadottir,Ragnar Freyr Ingvarsson,Brynja Thorsteinsdottir,Steinunn Kristjánsdóttir,Kolbrun Birgisdottir,Anna M. Kristinsdottir,Martin I. Sigurdsson,Gudny A. Arnadottir,Erna V. Ivarsdottir,Margret B. Andresdottir,Frosti Jonsson,Arna B Agustsdottir,Jonas Berglund,Berglind Eiriksdottir,Run Fridriksdottir,Elisabet E Gardarsdottir,Magnus Gottfredsson,Olafia S Gretarsdottir,Steinunn Gudmundsdottir,Kjartan R Gudmundsson,Thora R Gunnarsdottir,Arnaldur Gylfason,Agnar Helgason,Brynjar O. Jensson,Aslaug Jonasdottir,Hakon Jonsson,Thordur Kristjansson,Karl G. Kristinsson,Droplaug N Magnusdottir,Olafur T. Magnusson,Lovisa Bjork Olafsdottir,Solvi Rognvaldsson,Louise le Roux,Gudrun Sigmundsdottir,Asgeir Sigurdsson,Gardar Sveinbjornsson,Kristin E Sveinsdottir,Maney Sveinsdottir,Emil A Thorarensen,Bjarni Thorbjornsson,Marianna Thordardottir,Jona Saemundsdottir,S Hjortur Kristjansson,Kamilla S Josefsdottir,Gisli Masson,Gudmundur Georgsson,Mar Kristjansson,Alma D. Möller,Runolfur Palsson,Thorolfur Gudnason,Unnur Thorsteinsdottir,Ingileif Jonsdottir,Patrick Sulem,Kari Stefansson +61 more
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TLDR
The authors' results indicate that antiviral antibodies against SARS-CoV-2 did not decline within 4 months after diagnosis, and antiviral antibody titers assayed by two pan-Ig assays remained on a plateau for the remainder of the study.Abstract:
Background Little is known about the nature and durability of the humoral immune response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods We measure...read more
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Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.
Jennifer M. Dan,Jennifer M. Dan,Jose Mateus,Yu Kato,Kathryn M. Hastie,Esther Dawen Yu,Caterina E. Faliti,Alba Grifoni,Sydney I. Ramirez,Sydney I. Ramirez,Sonya Haupt,April Frazier,Catherine Nakao,Vamseedhar Rayaprolu,Stephen A. Rawlings,Bjoern Peters,Bjoern Peters,Florian Krammer,Viviana Simon,Erica Ollmann Saphire,Erica Ollmann Saphire,Davey M. Smith,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Shane Crotty,Shane Crotty +26 more
TL;DR: This article analyzed multiple compartments of circulating immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months after infection.
Journal ArticleDOI
Adaptive immunity to SARS-CoV-2 and COVID-19.
TL;DR: In this article, a picture has begun to emerge that reveals that CD4+ T cells, CD8+ Tcells, and neutralizing antibodies all contribute to control SARS-CoV-2 in both non-hospitalized and hospitalized cases of COVID-19.
Journal ArticleDOI
Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers.
Sheila F Lumley,Denise O'Donnell,Nicole Stoesser,Philippa C Matthews,Alison Howarth,Stephanie B Hatch,Brian D. Marsden,Stuart Cox,Tim James,Fiona Warren,Liam J Peck,Thomas G Ritter,Z de Toledo,Laura Warren,David Axten,Richard J. Cornall,E Y Jones,David I. Stuart,Gavin R. Screaton,Daniel Ebner,Sarah Hoosdally,Sarah Hoosdally,Meera Chand,D W Crook,D W Crook,O'Donnell A-M.,Christopher P. Conlon,Koen B. Pouwels,A S Walker,A S Walker,Peto Tea.,Susan Hopkins,Timothy M Walker,Katie Jeffery,David W Eyre +34 more
TL;DR: The relationship between the presence of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the risk of subsequent reinfection remains unclear as discussed by the authors.
Journal ArticleDOI
Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination.
Alicia T. Widge,Nadine Rouphael,Lisa A. Jackson,Evan J. Anderson,Paul C. Roberts,Mamodikoe Makhene,James D. Chappell,Mark R. Denison,Laura J. Stevens,Andrea J. Pruijssers,Adrian B. McDermott,Britta Flach,Bob C. Lin,Nicole A. Doria-Rose,Sijy O'Dell,Stephen D. Schmidt,Kathleen M. Neuzil,Hamilton Bennett,Brett Leav,Mat Makowski,Jim Albert,Kaitlyn Cross,Venkata Viswanadh Edara,Katharine Floyd,Mehul S. Suthar,Wendy Buchanan,Catherine J. Luke,Julie E. Ledgerwood,John R. Mascola,Barney S. Graham,John H. Beigel +30 more
TL;DR: A small number of adults received two 100-μg injections of Moderna’s mRNA SARS-CoV-2 vaccine, and serum anti–spike protein and neutralizing antibody titers revealed immunogenicity and safety concerns.
Journal ArticleDOI
Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications.
Andrew T. Levin,Andrew T. Levin,William P. Hanage,Nana Owusu-Boaitey,Kensington B. Cochran,Seamus P. Walsh,Gideon Meyerowitz-Katz +6 more
TL;DR: The results indicate that COVID-19 is hazardous not only for the elderly but also for middle-aged adults, for whom the infection fatality rate is two orders of magnitude greater than the annualized risk of a fatal automobile accident and far more dangerous than seasonal influenza.
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Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study.
Marina Pollán,Beatriz Pérez-Gómez,Roberto Pastor-Barriuso,Jesús Oteo,Miguel A. Hernán,Miguel A. Hernán,Mayte Pérez-Olmeda,Jose L Sanmartín,Aurora Fernández-García,Aurora Fernández-García,Israel Cruz,Nerea Fernández de Larrea,Marta Molina,Francisco Rodríguez-Cabrera,Mariano Martín,Paloma Merino-Amador,Jose León Paniagua,Juan F Muñoz-Montalvo,Faustino Blanco,Raquel Yotti,Rodrigo Gutiérrez Fernández,Saturnino Mezcua Navarro,Matías Salinero Hernández,Manuel Cuenca-Estrella,Pablo Fernández-Navarro,Ana Avellón,Giovanni Fedele,Jesús Oteo Iglesias,María Teresa Pérez Olmeda,Maria Elena Martinez,Francisco D. Rodríguez-Cabrera,Susana Padrones Fernández,José Manuel Rumbao Aguirre,José M. Navarro Marí,Begoña Palop Borrás,Ana Belén Pérez Jiménez,Manuel Rodríguez-Iglesias,Ana María Calvo Gascón,María Luz Lou Alcaine,Ignacio Donate Suárez,Oscar Suárez Álvarez,Mercedes Rodríguez Pérez,Margarita Cases Sanchís,Carlos Javier Villafáfila Gomila,Lluis Carbo Saladrigas,Adoración Hurtado Fernández,Antonio Oliver,Elías Castro Feliciano,María Noemí González Quintana,José María Barrasa Fernández,María Araceli Hernández Betancor,Melisa Hernández Febles,Leopoldo Martín Martín,Luis-Mariano López López,Teresa Ugarte Miota,Inés De Benito Población,María Sagrario Celada Pérez,María Natalia Vallés Fernández,Tomás Maté Enríquez,Miguel Villa Arranz,Marta Domínguez-Gil González,Isabel Fernández-Natal,Gregoria Megías Lobón,Juan Luis Muñoz Bellido,Pilar Ciruela,Ariadna Mas i Casals,Maria Doladé Botías,M. Angeles Marcos Maeso,Dúnia Pérez del Campo,Antonio Félix de Castro,Ramón Limón Ramírez,Maria Francisca Elías Retamosa,Manuela Rubio González,María Sinda Blanco Lobeiras,Alberto Fuentes Losada,Antonio Aguilera,Germán Bou,Yolanda Caro,Noemí Marauri,Luis Miguel Soria Blanco,Isabel González,Montserrat Hernández Pascual,Roberto Alonso Fernández,Natalia Cabrera Castro,Aurora Tomás Lizcano,Cristóbal Ramírez Almagro,M. Hernández,Nieves Ascunce Elizaga,María Ederra Sanz,Carmen Ezpeleta Baquedano,Ana Bustinduy Bascaran,Susana Iglesias Tamayo,Luis Elorduy Otazua,Rebeca Benarroch Benarroch,Jesús Lopera Flores,Antonia Vázquez de la Villa +95 more
TL;DR: In this paper, a nationwide population-based study aims to estimate the seroprevalence of SARS-CoV-2 infection in Spain at national and regional level.
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