R
Rui Xia
Researcher at University of Texas Health Science Center at Houston
Publications - 14
Citations - 739
Rui Xia is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Genome-wide association study & DNA methylation. The author has an hindex of 6, co-authored 14 publications receiving 371 citations.
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Journal ArticleDOI
Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood
Amit Khera,Mark Chaffin,Kaitlin H Wade,Sohail Zahid,Joseph Brancale,Rui Xia,Marina T. DiStefano,Ozlem Senol-Cosar,Ozlem Senol-Cosar,Ozlem Senol-Cosar,Mary E. Haas,Alexander G. Bick,Krishna G. Aragam,Eric S. Lander,George Davey Smith,Heather Mason-Suares,Heather Mason-Suares,Heather Mason-Suares,Myriam Fornage,Matthew S. Lebo,Matthew S. Lebo,Matthew S. Lebo,Nicholas J. Timpson,Lee M. Kaplan,Sekar Kathiresan +24 more
TL;DR: A new polygenic predictor comprised of 2.1 million common variants to quantify inherited susceptibility to obesity is derived and validated and test this predictor in more than 300,000 individuals ranging from middle age to birth.
Journal ArticleDOI
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
Daniel L. McCartney,Josine L. Min,Rebecca C Richmond,Ake T. Lu,Maria K. Sobczyk,Gail Davies,Linda Broer,Xiuqing Guo,Ayoung Jeong,Ayoung Jeong,Jeesun Jung,Silva Kasela,Seyma Katrinli,Pei-Lun Kuo,Pamela R. Matias-Garcia,Pashupati P. Mishra,Marianne Nygaard,Marianne Nygaard,Teemu Palviainen,Amit Patki,Laura M. Raffield,Scott M. Ratliff,Tom G. Richardson,Oliver Robinson,Mette Soerensen,Mette Soerensen,Dianjianyi Sun,Pei-Chien Tsai,Pei-Chien Tsai,Pei-Chien Tsai,Matthijs D. van der Zee,Matthijs D. van der Zee,Rosie M. Walker,Xiaochuan Wang,Yunzhang Wang,Rui Xia,Zongli Xu,Jie Yao,Wei Zhao,Adolfo Correa,Eric Boerwinkle,Pierre Antoine Dugué,Pierre Antoine Dugué,Pierre Antoine Dugué,Peter Durda,Hannah R Elliott,Christian Gieger,Eco J. C. de Geus,Eco J. C. de Geus,Sarah E. Harris,Gibran Hemani,Medea Imboden,Medea Imboden,Mika Kähönen,Sharon L.R. Kardia,Jacob K. Kresovich,Shengxu Li,Kathryn L. Lunetta,Massimo Mangino,Massimo Mangino,Dan Mason,Andrew M. McIntosh,Jonas Mengel-From,Jonas Mengel-From,Ann Zenobia Moore,Joanne M. Murabito,Miina Ollikainen,James S. Pankow,Nancy L. Pedersen,Annette Peters,Silvia Polidoro,David J. Porteous,Olli T. Raitakari,Olli T. Raitakari,Stephen S. Rich,Dale P. Sandler,Elina Sillanpää,Elina Sillanpää,Alicia K. Smith,Melissa C. Southey,Melissa C. Southey,Melissa C. Southey,Konstantin Strauch,Konstantin Strauch,Hemant K. Tiwari,Toshiko Tanaka,Therese Tillin,André G. Uitterlinden,David Van Den Berg,Jenny van Dongen,Jenny van Dongen,James G. Wilson,James G. Wilson,John Wright,Idil Yet,Idil Yet,Donna K. Arnett,Stefania Bandinelli,Jordana T. Bell,Alexandra M. Binder,Dorret I. Boomsma,Dorret I. Boomsma,Wei Chen,Kaare Christensen,Kaare Christensen,Karen N. Conneely,Paul Elliott,Luigi Ferrucci,Myriam Fornage,Sara Hägg,Caroline Hayward,Marguerite R. Irvin,Jaakko Kaprio,Debbie A Lawlor,Terho Lehtimäki,Falk W. Lohoff,Lili Milani,Roger L. Milne,Roger L. Milne,Roger L. Milne,Nicole Probst-Hensch,Nicole Probst-Hensch,Alexander P. Reiner,Beate Ritz,Jerome I. Rotter,Jennifer A. Smith,Jack A. Taylor,Joyce B. J. van Meurs,Paolo Vineis,Melanie Waldenberger,Ian J. Deary,Caroline L Relton,Steve Horvath,Riccardo E. Marioni +133 more
TL;DR: In this article, the authors identify 137 genome-wide significant loci, of which 113 are novel, from genomewide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels.
Journal ArticleDOI
Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.
Nicola J. Armstrong,Karen A. Mather,Muralidharan Sargurupremraj,Maria J. Knol,Rainer Malik,Claudia L. Satizabal,Lisa R. Yanek,Wei Wen,Vilmundur Gudnason,Nicole Dueker,Lloyd T. Elliott,Edith Hofer,Joshua C. Bis,Neda Jahanshad,Shuo Li,Mark A. Logue,Michelle Luciano,Markus Scholz,Albert V. Smith,Stella Trompet,Dina Vojinovic,Rui Xia,Fidel Alfaro-Almagro,David Ames,Najaf Amin,Philippe Amouyel,Alexa S. Beiser,Henry Brodaty,Ian J. Deary,Christine Fennema-Notestine,Piyush Gampawar,Rebecca F. Gottesman,Ludovica Griffanti,Clifford R. Jack,Mark Jenkinson,Jiyang Jiang,Brian G. Kral,John B.J. Kwok,Leonie Lampe,David C. Liewald,Pauline Maillard,Jonathan Marchini,Mark E. Bastin,Bernard Mazoyer,Lukas Pirpamer,Jose R. Romero,Gennady V. Roshchupkin,Peter R. Schofield,Matthias L. Schroeter,David J. Stott,Anbupalam Thalamuthu,Julian N. Trollor,Christophe Tzourio,Jeroen van der Grond,Meike W. Vernooij,Veronica A. Witte,Margaret J. Wright,Qiong Yang,Zoe Morris,Siggi Siggurdsson,Bruce M. Psaty,Arno Villringer,Helena Schmidt,Asta Håberg,Cornelia M. van Duijn,J. Wouter Jukema,Martin Dichgans,Ralph L. Sacco,Clinton B. Wright,William S. Kremen,Lewis C. Becker,Paul M. Thompson,Thomas H. Mosley,Joanna M. Wardlaw,M. Arfan Ikram,Hieab H.H. Adams,Sudha Seshadri,Perminder S. Sachdev,Stephen M. Smith,Lenore J. Launer,William T. Longstreth,Charles DeCarli,Reinhold Schmidt,Myriam Fornage,Stéphanie Debette,Paul A. Nyquist +85 more
TL;DR: Genetic analyses indicated PVWMH was more associated with ischemic stroke whilst DWMH loci were implicated in vascular, astrocyte, and neuronal function, and these phenotypes are distinct neuroimaging classifications and identifies new candidate genes associated with PVWMh only.
Journal ArticleDOI
Whole blood DNA methylation signatures of diet are associated with cardiovascular disease risk factors and all-cause mortality
Jianto Ma,Casey M. Rebholz,Kim V E Braun,Lindsay M. Reynolds,Stella Aslibekyan,Rui Xia,Niranjan G Biligowda,Tianxiao Huan,Chunyu Liu,Michael M Mendelson,Michael M Mendelson,Roby Joehanes,Emily A Hu,Mara Z. Vitolins,Alexis C. Wood,Kurt Lohman,Carolina Ochoa-Rosales,Joyce B. J. van Meurs,André G. Uitterlinden,Yongmei Liu,Mohamed A. Elhadad,Margit Heier,Melanie Waldenberger,Annette Peters,Elena Colicino,Eric A. Whitsel,Antoine R Baldassari,Sina A. Gharib,Nona Sotoodehnia,Jennifer A. Brody,Colleen M. Sitlani,Toshiko Tanaka,W. David Hill,Janie Corley,Ian J. Deary,Yan Zhang,Ben Schöttker,Ben Schöttker,Hermann Brenner,Hermann Brenner,Maura E Walker,Shumao Ye,Steve Nguyen,James S. Pankow,Ellen W. Demerath,Yinan Zheng,Lifang Hou,Liming Liang,Alice H. Lichtenstein,Frank B. Hu,Myriam Fornage,Trudy Voortman,Daniel Levy +52 more
TL;DR: Habitual diet quality was associated with differential peripheral leukocyte DNA methylation levels of 30 CpGs, most of which were also associated with multiple health outcomes, in European ancestry individuals, demonstrating that integrative genomic analysis of dietary information may reveal molecular targets for disease prevention and treatment.
Posted ContentDOI
Genetic determinants of cortical structure (thickness, surface area and volumes) among disease free adults in the CHARGE Consortium
Edith Hofer,Gennady V. Roshchupkin,Adams Hhh.,Maria J. Knol,Honghuang Lin,Simin Li,Zare H,Zare H,Shahzad Ahmad,Nicola J. Armstrong,Claudia L. Satizabal,Bernard M,J. C. Bis,Nathan A. Gillespie,Nathan A. Gillespie,Michelle Luciano,Aniket Mishra,Markus Scholz,Alexander Teumer,Rui Xia,Xueqiu Jian,Thomas H. Mosley,Yasaman Saba,Lukas Pirpamer,Stephan Seiler,James T. Becker,Owen Carmichael,Jerome I. Rotter,Bruce M. Psaty,Oscar L. Lopez,N. Amin,van der Lee Sj,Qiong Yang,Jayandra J. Himali,Pauline Maillard,Alexa S. Beiser,Charles C. DeCarli,Sherif Karama,Lindsay B. Lewis,Mathew A. Harris,Bastin Me,Ian J. Deary,A. V. Witte,A. V. Witte,Frauke Beyer,Frauke Beyer,Markus Loeffler,Karen A. Mather,Karen A. Mather,Peter R. Schofield,Peter R. Schofield,Anbu Thalamuthu,John B.J. Kwok,John B.J. Kwok,Margaret J. Wright,David Ames,David Ames,Julian N. Trollor,Jiyang Jiang,Henry Brodaty,Wei Wen,Meike W. Vernooij,Albert Hofman,A.G. Uitterlinden,Wiro J. Niessen,Katharina Wittfeld,Katharina Wittfeld,Robin Bülow,Uwe Völker,Zdenka Pausova,Zdenka Pausova,Pike Gb,Sophie Maingault,Fabrice Crivello,Christophe Tzourio,Amouye P,Amouye P,Bernard Mazoyer,Michael C. Neale,Carol E. Franz,Michael J. Lyons,Matthew S. Panizzon,Ole A. Andreassen,Anders M. Dale,Mark A. Logue,Katrina L. Grasby,Neda Jahanshad,Jodie N. Painter,Lucía Colodro-Conde,Janita Bralten,Derrek P. Hibar,Derrek P. Hibar,Penelope A. Lind,Fabrizio Pizzagalli,Jason L. Stein,Paul M. Thompson,S. E. Medland,Ching Christopher R,McMahon Mary Agnes B,Natalia Shatokhina,Leo Charles Peek Zsembik,Ingrid Agartz,Saud Alhusaini,Marcio Almeida,Dag Alnæs,Inge K Amlien,Magnus Andersson,Tyler Ard,Allison E. Ashley-Koch,Rachel M. Brouwer,Elizabeth E.L. Buimer,Bürger C,Dara M. Cannon,M. Mallar Chakravarty,Chen Q,Cheung Jw,Couvy-Duchesne B,Dalvie S,de Araujo Tk,de Zubicaray Gi,de Zwarte Sm,Braber Ad,Doan Nt,Dohm K,Ehrlich S,Engelbrecht H,Erk S,Fan Cc,Fedko Io,Foley Sf,Judith M. Ford,Fukunaga M,Garrett Me,Ge T,Sudheer Giddaluru,Goldman Al,Groenewold Na,Grotegerd D,Tiril P. Gurholt,Gutman Ba,Hansell Nk,Harris Ma,Marc B. Harrison,Courtney C. Haswell,Hauser M,Herms S,Dirk J. Heslenfeld,Ho Nf,Hoehn D,Hoffmann P,Laurena Holleran,Hoogman M,Hottenga J,Masashi Ikeda,Janowitz D,Jansen Ie,Jia T,Christiane Jockwitz,Kanai R,Kasperaviciute D,Kaufmann T,Kelly S,Kikuchi M,Klein M,Knapp M,Knodt Ar,Bernhard K. Krämer,Lam M,Lancaster Tm,Lee Ph,Tristram A. Lett,Lindsay B. Lewis,Lopes-Cendes I,Macciardi F,Marquand Af,Mathias,Melzer Tr,Yuri Milaneschi,Nazanin Mirza-Schreiber,Moreira Jc,Mühleisen Tw,Müller-Myhsok B,Najt P,Nakahara S,Nho K,Olde Loohuis Lm,Orfanos Dp,John F. Pearson,Toni L. Pitcher,Pütz B,Anjanibhargavi Ragothaman,Faisal Rashid,Ronny R,Reinbold Cs,Repple J,Richard G,Brandalyn C. Riedel,Risacher Sl,Cristiane S. Rocha,Nina Roth Mota,Lauren E. Salminen,Saremi A,Saykin Aj,Fenja Schlag,Schmaal L,Secolin R,Shapland Cy,Shen L,Shin J,Shumskaya E,Sønderby Ie,Sprooten E,Strike Lt,Tansey Ke,Sophia I. Thomopoulos,Tordesillas-Gutiérrez D,Turner Ja,Uhlmann A,Vallerga Cl,der Meer Dv,van Donkelaar Mm,Eijk Lv,van Erp Tg,van Haren Ne,va D +224 more
TL;DR: It is found that genetic heterogeneity between cortical measures and brain regions, and 161 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways are identified, which are a rich resource for studies of the biological mechanisms behind cortical development and aging.