M
Massimo Tommasino
Researcher at International Agency for Research on Cancer
Publications - 334
Citations - 14170
Massimo Tommasino is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: Cancer & HPV infection. The author has an hindex of 62, co-authored 312 publications receiving 12239 citations. Previous affiliations of Massimo Tommasino include German Cancer Research Center & World Health Organization.
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Journal ArticleDOI
Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome
Lorna Flanagan,Jasmin Schmid,Matthias P. Ebert,Pavel Soucek,Tereza Kunická,Vaclav Liska,Jan Bruha,Paul Neary,Nicki Dezeeuw,Massimo Tommasino,Mazda Jenab,Jochen H. M. Prehn,David J. Hughes +12 more
TL;DR: This is the first study examining Fusobacterium nucleatum (Fn) in the colonic tissue and stool of European CRC and CRA patients, and suggests Fn as a novel risk factor for disease progression from adenoma to cancer, possibly affecting patient survival outcomes.
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Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
Stephan J. Reshkin,Antonia Bellizzi,Sandra Caldeira,Valentina Albarani,Ilaria Malanchi,Manuela Poignee,Marianna Alunni-Fabbroni,Valeria Casavola,Massimo Tommasino +8 more
TL;DR: The data confirm that activation of the NHE‐1 and resulting cellular alkalinization is a key mechanism in oncogenic transformation and is necessary for the development and maintenance of the transformed phenotype.
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TLR9 expression and function is abolished by the cervical cancer-associated human papillomavirus type 16.
Uzma Hasan,Elizabeth E.M. Bates,Fumihiko Takeshita,Alexandra Biliato,Rosita Accardi,Véronique Bouvard,Mariam Mansour,Isabelle Vincent,Lutz Gissmann,Thomas Iftner,Mario Sideri,Frank Stubenrauch,Massimo Tommasino +12 more
TL;DR: A novel mechanism used by HPV16 to suppress the host immune response by deregulating the TLR9 transcript is revealed, providing evidence that abolishing innate responses may be a crucial step involved in the carcinogenic events mediated by HPVs.
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The human papillomavirus family and its role in carcinogenesis.
TL;DR: Additional research is necessary to characterize the biology and epidemiology of the vast number of HPV types that have been poorly investigated so far, with a final aim of clarifying their potential roles in other human diseases.
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The biological properties of E6 and E7 oncoproteins from human papillomaviruses
TL;DR: Most of the findings on the biological properties and molecular mechanisms of the oncoproteins E6 and E7 from mucosal and cutaneous HPV types are reviewed.