M
Matteo Bianchi
Researcher at Scripps Research Institute
Publications - 21
Citations - 1343
Matteo Bianchi is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 10, co-authored 20 publications receiving 1126 citations. Previous affiliations of Matteo Bianchi include International AIDS Vaccine Initiative & Boston Children's Hospital.
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Journal ArticleDOI
Restoration of NET formation by gene therapy in CGD controls aspergillosis
Matteo Bianchi,Abdul Hakkim,Volker Brinkmann,Ulrich Siler,Reinhard Seger,Arturo Zychlinsky,Janine Reichenbach +6 more
TL;DR: It is shown that reconstitution of NET formation by gene therapy in a patient with CGD restores neutrophil elimination of A nidulans conidia and hyphae and is associated with rapid cure of preexisting therapy refractory invasive pulmonary aspergillosis, underlining the role of functional NADPH oxidase in NET formation and antifungal activity.
Journal ArticleDOI
Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent
TL;DR: In this article, Aspergillus spp infection is a potentially lethal disease in patients with neutropenia or impaired neutrophil function, and the authors showed that the infection is potentially lethal.
Journal ArticleDOI
Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization
Matteo Bianchi,Hannah L. Turner,Bartek Nogal,Christopher A. Cottrell,David Oyen,Matthias Pauthner,Raiza Bastidas,Rebecca Nedellec,Laura E. McCoy,Ian A. Wilson,Dennis R. Burton,Andrew B. Ward,Andrew B. Ward,Lars Hangartner +13 more
TL;DR: A method of characterizing polyclonal responses by using electron microscopy is described, and this method is applied to the immunization of rabbits with an HIV‐1 envelope glycoprotein vaccine candidate, BG505 SOSIP.
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Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers.
Matthias Pauthner,Joseph P. Nkolola,Colin Havenar-Daughton,Colin Havenar-Daughton,Ben Murrell,Samantha M. Reiss,Samantha M. Reiss,Raiza Bastidas,Jérémie Prévost,Rebecca Nedellec,Benjamin von Bredow,Peter Abbink,Christopher A. Cottrell,Daniel W. Kulp,Talar Tokatlian,Talar Tokatlian,Bartek Nogal,Matteo Bianchi,Hui Li,Jeong Hyun Lee,Jeong Hyun Lee,Salvatore T. Butera,David T. Evans,Lars Hangartner,Andrés Finzi,Andrés Finzi,Ian A. Wilson,Richard T. Wyatt,Darrell J. Irvine,William R. Schief,Andrew B. Ward,Rogier W. Sanders,Rogier W. Sanders,Shane Crotty,Shane Crotty,Shane Crotty,George M. Shaw,Dan H. Barouch,Dan H. Barouch,Dennis R. Burton +39 more
TL;DR: Protection from hard‐to‐neutralize SHIVBG505 challenge after immunization with native‐like BG505 Envelope trimers in nonhuman primates is studied and neutralizing antibodies, but not T cell or ADCC activity, are identified, as correlates of protection.
Journal ArticleDOI
Mapping Polyclonal Antibody Responses in Non-human Primates Vaccinated with HIV Env Trimer Subunit Vaccines.
Bartek Nogal,Matteo Bianchi,Christopher A. Cottrell,Robert N. Kirchdoerfer,L.M. Sewall,Hannah L. Turner,Fangzhu Zhao,Devin Sok,Dennis R. Burton,Lars Hangartner,Andrew B. Ward +10 more
TL;DR: In this paper, electron microscopy polyclonal epitope mapping is used to describe antibody specificities elicited by immunization of non-human primates with soluble HIV envelope trimers and subsequent repeated viral challenge.