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Matthew J. Edwards
Researcher at Novartis
Publications - 29
Citations - 2098
Matthew J. Edwards is an academic researcher from Novartis. The author has contributed to research in topics: Thymic stromal lymphopoietin & Asthma. The author has an hindex of 16, co-authored 28 publications receiving 1794 citations. Previous affiliations of Matthew J. Edwards include Edward Jenner Institute for Vaccine Research.
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Journal ArticleDOI
IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo
David A. Jackson,David A. Jackson,Heidi Makrinioti,Batika M. J. Rana,Betty Shamji,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Joseph Footitt,Joseph Footitt,Jerico del-Rosario,Jerico del-Rosario,Aurica G. Telcian,A A Nikonova,Jie Zhu,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Stephanie Traub,Jaideep Dhariwal,Jaideep Dhariwal,James D. Porter,Duncan Hunt,Toby Hunt,Trevor Hunt,Luminita A. Stanciu,Musa Khaitov,Nathan W. Bartlett,Michael R. Edwards,Onn Min Kon,Patrick Mallia,Patrick Mallia,Nikolaos G. Papadopoulos,Cezmi A. Akdis,John Westwick,Matthew J. Edwards,David J. Cousins,Ross P. Walton,Sebastian L. Johnston,Sebastian L. Johnston +38 more
TL;DR: IL-33 and type 2 cytokines are induced during a rhinovirus-induced asthma exacerbation in vivo and relate to exacerbation severity, which is a novel therapeutic approach for asthma exacerbations.
Journal ArticleDOI
Expression and Cellular Provenance of Thymic Stromal Lymphopoietin and Chemokines in Patients with Severe Asthma and Chronic Obstructive Pulmonary Disease
Sun Ying,Brian J. O'Connor,Jonathan Ratoff,Qiu Meng,Cailong Fang,David J. Cousins,Guizhen Zhang,Shuyan Gu,Zhongli Gao,Betty Shamji,Matthew J. Edwards,Tak H. Lee,Christopher Corrigan +12 more
TL;DR: It is hypothesized that there is distinct airways expression of TSLP and chemokines which preferentially attract Th1- and Th2-type T cells, and influx of T cells bearing their receptors in asthma and COPD.
Journal ArticleDOI
Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation
Janine Beale,Janine Beale,Janine Beale,Annabelle Jayaraman,Annabelle Jayaraman,Annabelle Jayaraman,David A. Jackson,Jonathan Macintyre,Michael R. Edwards,Michael R. Edwards,Ross P. Walton,Ross P. Walton,Ross P. Walton,Jie Zhu,Jie Zhu,Jie Zhu,Yee Man Ching,Yee Man Ching,Yee Man Ching,Betty Shamji,Matthew J. Edwards,John Westwick,David J. Cousins,David J. Cousins,You Yi Hwang,Andrew N. J. McKenzie,Sebastian L. Johnston,Nathan W. Bartlett,Nathan W. Bartlett,Nathan W. Bartlett +29 more
TL;DR: Asthmatic epithelial cells have an increased intrinsic capacity for expression of a pro–type 2 cytokine in response to a viral infection, and IL-25 is a key mediator of RV-induced exacerbations of pulmonary inflammation.
Journal ArticleDOI
Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung
Henry Danahay,Angelica D. Pessotti,Julie Coote,Brooke E. Montgomery,Donghui Xia,Aaron C. Wilson,Haidi Yang,Zhao Wang,Luke Bevan,Chris Thomas,Stephanie Petit,Anne Serdakowski London,Peter LeMotte,Arno Doelemeyer,Germán L. Vélez-Reyes,Paula Bernasconi,Christy Fryer,Matthew J. Edwards,Paola Capodieci,Amy Chen,Marc Hild,Aron B. Jaffe +21 more
TL;DR: It is concluded that inhibition of Notch2 prevents goblet cell metaplasia induced by a broad range of stimuli and proposed notch2 neutralization as a therapeutic strategy for preventing gobleT cell metaPLasia in airway diseases.
Journal ArticleDOI
Oxidative Stress–induced Antibodies to Carbonyl-modified Protein Correlate with Severity of Chronic Obstructive Pulmonary Disease
Paul Kirkham,Gaetano Caramori,Paolo Casolari,Alberto Papi,Matthew J. Edwards,Betty Shamji,Kostas Triantaphyllopoulos,Farhana Hussain,Mariona Pinart,Younis Khan,Lucy Heinemann,Laurie Stevens,Mike Yeadon,Peter J. Barnes,Kian Fan Chung,Ian M. Adcock +15 more
TL;DR: Carbononyl-modified proteins, arising as a result of oxidative stress, promote antibody production, providing a link by which oxidative stress could drive an autoimmune response in COPD.