M
Matthias Altmeyer
Researcher at University of Zurich
Publications - 83
Citations - 6440
Matthias Altmeyer is an academic researcher from University of Zurich. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 31, co-authored 75 publications receiving 5055 citations. Previous affiliations of Matthias Altmeyer include MESA+ Institute for Nanotechnology & University of Copenhagen.
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Journal ArticleDOI
ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
Luis I. Toledo,Matthias Altmeyer,Maj-Britt Rask,Claudia Lukas,Dorthe Helena Larsen,Lou Klitgaard Povlsen,Simon Bekker-Jensen,Niels Mailand,Jiri Bartek,Jiri Lukas +9 more
TL;DR: ATR-mediated suppression of dormant origins shields active forks against irreversible breakage via preventing exhaustion of nuclear RPA, elucidates how replicating genomes avoid destabilizing DNA damage and provides a molecular rationale for their hypersensitivity to ATR inhibitors.
Journal ArticleDOI
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).
Matthias Altmeyer,Matthias Altmeyer,Kai John Neelsen,Federico Teloni,Irina Pozdnyakova,Stefania Pellegrino,Merete Grøfte,Maj-Britt Rask,Werner Streicher,Werner Streicher,Stephanie Jungmichel,Michael L. Nielsen,Jiri Lukas +12 more
TL;DR: In vitro and in vivo, it is shown that the nucleic acid-mimicking biopolymer poly(ADP-ribose) (PAR) nucleates intracellular liquid demixing, which is a general mechanism to dynamically reorganize the soluble nuclear space with implications for pathological protein aggregation caused by derailed phase separation.
Journal ArticleDOI
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.
Gyula Timinszky,Susanne Till,Paul O. Hassa,Michael Hothorn,Georg Kustatscher,Bianca Nijmeijer,Julien Colombelli,Matthias Altmeyer,Ernst H. K. Stelzer,Klaus Scheffzek,Michael O. Hottiger,Andreas G. Ladurner +11 more
TL;DR: Macrodomains are identified as modules that directly sense PARP activation in vivo and establish macroH2A histones as dynamic regulators of chromatin plasticity.
Journal ArticleDOI
Complete genome sequence of the myxobacterium Sorangium cellulosum
Susanne Schneiker,Olena Perlova,Olaf Kaiser,Klaus Gerth,Aysel Alici,Matthias Altmeyer,Daniela Bartels,Thomas Bekel,Stefan Beyer,Edna Bode,Helge B. Bode,Christoph J. Bolten,Jomuna V. Choudhuri,Sabrina D. Doss,Yasser A. Elnakady,Bettina Frank,Lars Gaigalat,Alexander Goesmann,Carolin Groeger,Frank Gross,Lars Jelsbak,Lotte Jelsbak,Jörn Kalinowski,Carsten Kegler,Tina Knauber,Sebastian Konietzny,Maren Kopp,Lutz Krause,Daniel Krug,Bukhard Linke,Taifo Mahmud,Rosa Martínez-Arias,Alice C. McHardy,Michelle Merai,Folker Meyer,Sascha Mormann,José Muñoz-Dorado,Juana Pérez,Silke Pradella,Shwan Rachid,Günter Raddatz,Frank Rosenau,Christian Rückert,Florenz Sasse,Maren Scharfe,Stephan C. Schuster,Garret Suen,Anke Treuner-Lange,Gregory J. Velicer,Frank-Jörg Vorhölter,Kira J. Weissman,Roy D. Welch,Silke C. Wenzel,David E. Whitworth,Susanne Wilhelm,Christoph Wittmann,Helmut Blöcker,Alfred Pühler,Rolf Müller +58 more
TL;DR: The complete genome sequence of the model Sorangium strain S. cellulosum So ce56 is reported, which produces several natural products and has morphological and physiological properties typical of the genus, and the circular genome is the largest bacterial genome sequenced to date.
Journal ArticleDOI
Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
TL;DR: It is shown that glutamic acid residues in the auto-modification domain of PARP1 are not required for PAR formation and individual lysine residues as acceptor sites for ADP-ribosylation, which provides novel mechanistic insights into PAR synthesis with significant relevance for the different biological functions ofPARP family members.