A
Amy L. Hartman
Researcher at University of Pittsburgh
Publications - 61
Citations - 4151
Amy L. Hartman is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Encephalitis & Rift Valley fever. The author has an hindex of 23, co-authored 54 publications receiving 3242 citations. Previous affiliations of Amy L. Hartman include Centers for Disease Control and Prevention.
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Journal ArticleDOI
Animal models for COVID-19.
César Muñoz-Fontela,William E. Dowling,Simon G. P. Funnell,Pierre Stéphane Gsell,A. Ximena Riveros-Balta,Randy A. Albrecht,Hanne Leth Andersen,Ralph S. Baric,Miles W. Carroll,Marco Cavaleri,Chuan Qin,Ian Crozier,Kai Dallmeier,Leon de Waal,Emmie de Wit,Leen Delang,Erik D. Dohm,W. Paul Duprex,Darryl Falzarano,Courtney L. Finch,Matthew B. Frieman,Barney S. Graham,Lisa E. Gralinski,Kate Guilfoyle,Bart L. Haagmans,Geraldine A. Hamilton,Amy L. Hartman,Sander Herfst,Suzanne J.F. Kaptein,William B. Klimstra,Ivana Knezevic,Philip R. Krause,Jens H. Kuhn,Roger Le Grand,Mark G. Lewis,Wen-Chun Liu,Pauline Maisonnasse,Anita K. McElroy,Vincent J. Munster,Nadia Oreshkova,Angela L. Rasmussen,Joana Rocha-Pereira,Barry Rockx,Estefanía Rodríguez,Thomas F. Rogers,Francisco J. Salguero,Michael Schotsaert,Koert J. Stittelaar,Hendrik Jan Thibaut,Chien Te K. Tseng,Júlia Vergara-Alert,Martin Beer,Trevor Brasel,Jasper Fuk-Woo Chan,Adolfo García-Sastre,Johan Neyts,Stanley Perlman,Douglas S. Reed,Juergen A. Richt,Chad J. Roy,Joaquim Segalés,Seshadri S. Vasan,Seshadri S. Vasan,Ana Maria Henao-Restrepo,Dan H. Barouch +64 more
TL;DR: The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.
Journal ArticleDOI
Ebola Virus VP35 Protein Binds Double-Stranded RNA and Inhibits Alpha/Beta Interferon Production Induced by RIG-I Signaling
Washington B. Cárdenas,Yueh Ming Loo,Michael Gale,Amy L. Hartman,Christopher R. Kimberlin,Luis Martinez-Sobrido,Erica Ollmann Saphire,Christopher F. Basler +7 more
TL;DR: Evidence is provided that VP35 possesses double-stranded RNA (dsRNA)-binding activity, which supports the hypothesis that dsRNA binding may contribute to VP35 IFN antagonist function, and that additional mechanisms of inhibition, at a point proximal to the IRF-3 kinases, most likely also exist.
Journal ArticleDOI
Ebola Virus VP24 Binds Karyopherin α1 and Blocks STAT1 Nuclear Accumulation
St. Patrick Reid,Lawrence W. Leung,Amy L. Hartman,Osvaldo Martinez,Megan L. Shaw,Caroline Carbonnelle,Viktor E. Volchkov,Stuart T. Nichol,Christopher F. Basler +8 more
TL;DR: It is demonstrated that the EBOV VP24 protein functions as an inhibitor ofIFN-α/β and IFN-γ signaling, and is likely to be an important virulence determinant that allows E BOV to evade the antiviral effects of IFNs.
Journal ArticleDOI
Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola.
Jonathan S. Towner,Marina L. Khristova,Tara K. Sealy,Martin J. Vincent,Bobbie R. Erickson,Darcy A. Bawiec,Amy L. Hartman,James A. Comer,Sherif R. Zaki,Ute Ströher,Ute Ströher,Filomena Gomes da Silva,Fernando del Castillo,Pierre E. Rollin,Thomas G. Ksiazek,Stuart T. Nichol +15 more
TL;DR: While the marburgviruses exhibit high overall genetic diversity, only 6.8% nucleotide difference was found between the West African Angolan viruses and the majority of East African viruses, suggesting that the virus reservoir species in these regions are not substantially distinct.
Journal ArticleDOI
Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions.
Alyssa C. Fears,William B. Klimstra,Paul Duprex,Amy L. Hartman,Scott C. Weaver,Kenneth S. Plante,Divya Mirchandani,Jessica A. Plante,Patricia V. Aguilar,Diana Fernández,Aysegul Nalca,Aysegul Totura,David W. Dyer,Brian J. Kearney,Matthew G. Lackemeyer,J. Kyle Bohannon,Reed F. Johnson,Robert F. Garry,Doug S. Reed,Chad J. Roy +19 more
TL;DR: Its dynamic aerosol efficiency surpassed those of severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome and its findings suggest retained infectivity and virion integrity for up to 16 hours in respirable-sized aerosols.