M
Michael F. Hirshman
Researcher at Harvard University
Publications - 143
Citations - 22282
Michael F. Hirshman is an academic researcher from Harvard University. The author has contributed to research in topics: Skeletal muscle & Glucose uptake. The author has an hindex of 65, co-authored 131 publications receiving 20279 citations. Previous affiliations of Michael F. Hirshman include Merck & Co. & Joslin Diabetes Center.
Papers
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Journal ArticleDOI
Role of AMP-activated protein kinase in mechanism of metformin action
Gaochao Zhou,Robert W. Myers,Ying Li,Yuli Chen,Xiaolan Shen,Judy Fenyk-Melody,Margaret Wu,John Ventre,Thomas W. Doebber,Nobuharu Fujii,Nicolas Musi,Michael F. Hirshman,Laurie J. Goodyear,David E. Moller +13 more
TL;DR: It is reported that metformin activates AMPK in hepatocytes; as a result, acetyl-CoA carboxylase (ACC) activity is reduced, fatty acid oxidation is induced, and expression of lipogenic enzymes is suppressed.
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Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
Kristin I. Stanford,Roeland J.W. Middelbeek,Kristy L. Townsend,Ding An,Eva B. Nygaard,Kristen M. Hitchcox,Kathleen R. Markan,Kazuhiro Nakano,Michael F. Hirshman,Yu-Hua Tseng,Laurie J. Goodyear +10 more
TL;DR: A previously under-appreciated role for BAT in glucose metabolism is revealed, demonstrating that BAT-derived IL-6 is required for the profound effects of BAT transplantation on glucose homeostasis and insulin sensitivity.
Journal ArticleDOI
Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.
Nicolas Musi,Michael F. Hirshman,Jonas Nygren,Monika Svanfeldt,Peter Båvenholm,Olav Rooyackers,Gaochao Zhou,Joanne M. Williamson,Olle Ljunqvist,Suad Efendic,David E. Moller,Anders Thorell,Laurie J. Goodyear +12 more
TL;DR: The findings suggest that the metabolic effects of metformin in subjects with type 2 diabetes may be mediated by the activation of AMPK alpha2, which is implicated in the stimulation of glucose uptake into skeletal muscle and the inhibition of liver gluconeogenesis.
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Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
TL;DR: Data suggest that AICAR and contraction stimulate glucose transport by a similar insulin-independent signaling mechanism and are consistent with the hypothesis that AMPK is involved in exercise-stimulated glucose uptake.
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5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle.
TL;DR: Evidence is provided that the increased glucose uptake observed with AMPK activation by AICA-riboside in perfused rat hindlimb muscles is due to an increase in the translocation of GLUT4 to surface membranes.