M
Michelle Schorn
Researcher at University of California, San Diego
Publications - 18
Citations - 3136
Michelle Schorn is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 11, co-authored 15 publications receiving 2733 citations. Previous affiliations of Michelle Schorn include Life Technologies & Wageningen University and Research Centre.
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Journal ArticleDOI
An integrated semiconductor device enabling non-optical genome sequencing
Jonathan M. Rothberg,Wolfgang Hinz,Todd Rearick,Jonathan Schultz,William J. Mileski,Melville Davey,John H. Leamon,Kim L. Johnson,Mark James Milgrew,Matthew D. Edwards,Jeremy Hoon,Jan Fredrik Simons,David Marran,Jason W. Myers,John F. Davidson,Annika Branting,John Nobile,Bernard P. Puc,David Light,Travis A. Clark,Martin Huber,Jeffrey T. Branciforte,Isaac B. Stoner,Simon Cawley,Michael R. Lyons,Yutao Fu,Nils Homer,Marina Sedova,Xin Miao,Brian Reed,Jeffrey Sabina,Erika Feierstein,Michelle Schorn,Mohammad Alanjary,Eileen T. Dimalanta,Devin Dressman,Rachel Kasinskas,Tanya Sokolsky,Jacqueline A. Fidanza,Eugeni Namsaraev,Kevin McKernan,Alan Williams,G. Thomas Roth,James Bustillo +43 more
TL;DR: A DNA sequencing technology in which scalable, low-cost semiconductor manufacturing techniques are used to make an integrated circuit able to directly perform non-optical DNA sequencing of genomes, showing its robustness and scalability by producing ion chips with up to 10 times as many sensors and sequencing a human genome.
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Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
Vinayak Agarwal,Abrahim El Gamal,Kazuya Yamanaka,Dennis Poth,Roland D. Kersten,Michelle Schorn,Eric E. Allen,Bradley S. Moore +7 more
TL;DR: In this article, the authors report marine bacteria as producers of polybrominated diphenyl ethers (PBDEs) and establish a genetic and molecular foundation for their production that unifies paradigms for the elaboration of bromophenols and bromopyrroles abundant in marine biota.
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Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges
Vinayak Agarwal,Jessica M. Blanton,Sheila Podell,Arnaud Taton,Michelle Schorn,Julia Busch,Zhenjian Lin,Eric W. Schmidt,Paul R. Jensen,Valerie J. Paul,Jason S. Biggs,James W. Golden,Eric E. Allen,Bradley S. Moore +13 more
TL;DR: The results establish the genetic and molecular foundation for the production of PBDEs in one of the most abundant natural sources of these molecules, further setting the stage for a metagenomic-based inventory of other PBDE sources in the marine environment.
Journal ArticleDOI
Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides.
Don D. Nguyen,Alexey V. Melnik,Nobuhiro Koyama,Nobuhiro Koyama,Xiaowen Lu,Michelle Schorn,Jinshu Fang,Kristen Aguinaldo,Tommie Lincecum,Maarten G. K. Ghequire,Víctor J. Carrión,Tina L. Cheng,Brendan M. Duggan,Jacob G. Malone,Jacob G. Malone,Tim H. Mauchline,Laura M. Sanchez,A. Marm Kilpatrick,Jos M. Raaijmakers,René De Mot,Bradley S. Moore,Bradley S. Moore,Marnix H. Medema,Pieter C. Dorrestein,Pieter C. Dorrestein +24 more
TL;DR: By indexing the Pseudomonas specialized metabolome, this work reports the molecular-networking-based discovery of four molecules and their evolutionary relationships: a poaeamide analogue and a molecular subfamily of cyclic lipopeptides, bananamides 1, 2 and 3.
Journal ArticleDOI
Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair.
Abrahim El Gamal,Vinayak Agarwal,Stefan Diethelm,Imran R Rahman,Michelle Schorn,Jennifer M. Sneed,Gordon V. Louie,Gordon V. Louie,Kristen E. Whalen,Tracy J. Mincer,Joseph P. Noel,Joseph P. Noel,Valerie J. Paul,Bradley S. Moore +13 more
TL;DR: The study of tetrabromopyrrole biosynthesis revealed a uniquely adapted halogenase–thioesterase enzyme pair that catalyzes an unprecedented series of halogenations on a pyrrole, providing a biogenetic basis for the biosynthesis of 1 and setting a firm foundation for querying the biosynthetic potential for the production of 1 in marine (meta)genomes.