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Nicholas D. Johnson
Researcher at Salk Institute for Biological Studies
Publications - 3
Citations - 1635
Nicholas D. Johnson is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Gene & Epigenomics. The author has an hindex of 1, co-authored 1 publications receiving 1437 citations.
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Journal ArticleDOI
Global Epigenomic Reconfiguration During Mammalian Brain Development
Ryan Lister,Ryan Lister,Eran A. Mukamel,Joseph R. Nery,Mark A. Urich,Clare A. Puddifoot,Nicholas D. Johnson,Jacinta Lucero,Yun Huang,Andrew J. Dwork,Matthew D. Schultz,Matthew D. Schultz,Miao Yu,Julian Tonti-Filippini,Holger Heyn,Shijun Hu,Joseph C. Wu,Anjana Rao,Manel Esteller,Chuan He,Fatemeh Haghighi,Terrence J. Sejnowski,Terrence J. Sejnowski,M. Margarita Behrens,Joseph R. Ecker +24 more
TL;DR: The results extend the knowledge of the unique role of DNA methylation in brain development and function, and offer a new framework for testing the role of the epigenome in healthy function and in pathological disruptions of neural circuits.
Posted ContentDOI
Epigenomic complexity of the human brain revealed by single-cell DNA methylomes and 3D genome structures
Wei Tian,Jingtian Zhou,Anna Bartlett,Qiurui Zeng,Huan Liu,Rosa Castanon,M. W. Kenworthy,Jordan Altshul,Cynthia Valadon,Andrew Aldridge,Joseph R. Nery,Huaming Chen,Jiaying Xu,Nicholas D. Johnson,Jacinta Lucero,Julia K. Osteen,Nora Emerson,Jon Rink,Jasper Lee,Yang Eric Li,Kimberly Siletti,Michelle Liem,Naomi Claffey,Caz O'Connor,Anna Marie Yanny,Julie Nyhus,Nick Dee,Tamara Casper,Nadiya V. Shapovalova,Daniel Hirschstein,Rebecca D. Hodge,Boaz P. Levi,C. Dirk Keene,Sten Linnarsson,Ed S. Lein,Bing Ren,M. Margarita Behrens,Joseph R. Ecker +37 more
TL;DR: In this article , the authors comprehensively examined human brain cell epigenomes by probing DNA methylation and chromatin conformation at single-cell resolution in over 500,000 cells from 46 brain regions.
Posted ContentDOI
A comparative atlas of single-cell chromatin accessibility in the human brain
Yang Eric Li,Sebastian Preissl,Michael Miller,Nicholas D. Johnson,Zihan Wang,Henry Jiao,Chenxu Zhu,Zhaoning Wang,Yang Xie,Olivier Poirion,Colin Kern,Antonio Pinto-Duarte,Wei Tian,Kimberly Siletti,Nora Emerson,Julia K. Osteen,Jacinta Lucero,Lin Lin,Qian Yang,Quan Zhu,Sarah Espinoza,Anna Marie Yanny,Julie Nyhus,Nick Dee,Tamara Casper,Nadiya V. Shapovalova,Daniel Hirschstein,Rebecca D. Hodge,Sten Linnarsson,Trygve E. Bakken,Boaz P. Levi,C. Dirk Keene,Jingbo Shang,Ed S. Lein,Allen Wang,M. Margarita Behrens,Joseph R. Ecker,Bing Ren +37 more
TL;DR: In this paper , the authors carried out single nucleus ATAC-seq analysis to probe the open chromatin landscape from over 1.1 million cells in 42 brain regions of three neurotypical adult donors.