Anna Marie Yanny

TL;DR: The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals using high-throughput transcriptomic and epigenomic profiling of more than 450k single nuclei in humans, marmoset monkeys and mice as mentioned in this paper.

TL;DR: This study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps, and establishes a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.

TL;DR: The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally conserved across mammals, and a broadly conserved cellular makeup is demonstrated, whose similarity mirrors evolutionary distance and is consistent between the transcriptome and epigenome.

TL;DR: The gene expression profile of von Economo neurons is revealed and it is shown that they are likely long-distance projection neurons, which suggest that VENs are a regionally distinctive type of ET neuron.

TL;DR: In this article, the authors leveraged the recent discovery of a transcriptomically defined L5 extratelencephalic-projecting (ET) neuron type to study the properties of human L5 ET neurons in neocortical brain slices derived from neurosurgeries.