Yang Eric Li

TL;DR: The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals using high-throughput transcriptomic and epigenomic profiling of more than 450k single nuclei in humans, marmoset monkeys and mice as mentioned in this paper.

TL;DR: This study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps, and establishes a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.

TL;DR: Paired-Tag as discussed by the authors was used to profile five histone modifications jointly with transcriptome in the adult mouse frontal cortex and hippocampus to produce cell-type-resolved maps of chromatin state and transcriptome.

TL;DR: In this article, single-cell chromatin accessibility assays to 30 adult human tissue types from multiple donors were used to profile the activity of gene regulatory elements in diverse cell types and tissues in the human body.

TL;DR: In this paper, a reference atlas of diverse neuronal and non-neuronal cell types in the mouse primary motor cortex is presented, including a population of excitatory neurons that resemble pyramidal cells in layer 4.