P
Paul H. M. Savelkoul
Researcher at Maastricht University
Publications - 253
Citations - 12176
Paul H. M. Savelkoul is an academic researcher from Maastricht University. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 52, co-authored 233 publications receiving 10186 citations. Previous affiliations of Paul H. M. Savelkoul include Vanderbilt University Medical Center & University of Amsterdam.
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Journal ArticleDOI
Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer.
Christian J. H. von Wintersdorff,John Penders,Julius M. van Niekerk,Nathan D. Mills,Snehali Majumder,Lieke B. van Alphen,Paul H. M. Savelkoul,Paul H. M. Savelkoul,Petra F. G. Wolffs +8 more
TL;DR: The concept of the resistome is discussed, examples of HGT of clinically relevant ARGs are provided and an overview of the current knowledge of the contributions the various HGT mechanisms make to the spread of antibiotic resistance is presented.
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Extended-spectrum β-lactamase genes of Escherichia coli in chicken meat and humans, The Netherlands.
I. T. M. A. Overdevest,Ina Willemsen,Martine C. Rijnsburger,Andrew Eustace,Li Xu,Peter M. Hawkey,Max Heck,Paul H. M. Savelkoul,Christina M. J. E. Vandenbroucke-Grauls,Kim van der Zwaluw,Xander W. Huijsdens,Jan Kluytmans +11 more
TL;DR: The findings suggest that the abundant presence of ESBL genes in the food chain may have a profound effect on future treatment options for a wide range of infections caused by gram-negative bacteria.
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Amplified-Fragment Length Polymorphism Analysis: the State of an Art
Paul H. M. Savelkoul,Henk Aarts,J. de Haas,L. Dijkshoorn,Birgitta Duim,Myrthe Otsen,J. L. W. Rademaker,Leo M. Schouls,Johannes A. Lenstra +8 more
TL;DR: In the past decade, various methods have been developed for the identification and typing of prokaryotic and eukaryotic organisms at the DNA level but these methods differ in their taxonomic range, discriminatory power, reproducibility, and ease of interpretation and standardization.
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New developments in the diagnosis of bloodstream infections
Remco P. H. Peters,Michiel A. van Agtmael,S. A. Danner,Paul H. M. Savelkoul,Christina M. J. E. Vandenbroucke-Grauls +4 more
TL;DR: Molecular assays are expected eventually to replace the current conventional microbiological techniques for detection of bloodstream infections and interpretation is complex, however, because of detection of DNA rather than living pathogens, the risk of interfering contamination, the presence of background DNA in blood, and the lack of a gold standard.
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Comparison of Seven Techniques for Typing International Epidemic Strains of Clostridium difficile: Restriction Endonuclease Analysis, Pulsed-Field Gel Electrophoresis, PCR-Ribotyping, Multilocus Sequence Typing, Multilocus Variable-Number Tandem-Repeat Analysis, Amplified Fragment Length Polymorphism, and Surface Layer Protein A Gene Sequence Typing
George Killgore,Angela Thompson,Stuart Johnson,Jon S. Brazier,Ed J. Kuijper,Jacques Pépin,Eric Frost,Paul H. M. Savelkoul,Brad Nicholson,Renate J. van den Berg,Haru Kato,Susan P. Sambol,Walter Zukowski,Christopher W. Woods,Brandi Limbago,Dale N. Gerding,L. Clifford McDonald +16 more
TL;DR: All techniques appear to be capable of detecting outbreak strains, but only REA and MLVA showed sufficient discrimination to distinguish strains from different outbreaks.