P
Paul I. Costea
Researcher at Royal Institute of Technology
Publications - 30
Citations - 12150
Paul I. Costea is an academic researcher from Royal Institute of Technology. The author has contributed to research in topics: Microbiome & Metagenomics. The author has an hindex of 24, co-authored 29 publications receiving 8219 citations. Previous affiliations of Paul I. Costea include Weizmann Institute of Science.
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Journal ArticleDOI
Structure and function of the global ocean microbiome
Shinichi Sunagawa,Luis Pedro Coelho,Samuel Chaffron,Jens Roat Kultima,Karine Labadie,Guillem Salazar,Bardya Djahanschiri,Georg Zeller,Daniel R. Mende,Adriana Alberti,Francisco M. Cornejo-Castillo,Paul I. Costea,Corinne Cruaud,Francesco d'Ovidio,Stefan Engelen,Isabel Ferrera,Josep M. Gasol,Lionel Guidi,Falk Hildebrand,Florian Kokoszka,Cyrille Lepoivre,Gipsi Lima-Mendez,Julie Poulain,Bonnie T. Poulos,Marta Royo-Llonch,Hugo Sarmento,Sara Vieira-Silva,Céline Dimier,Marc Picheral,Sarah Searson,Stefanie Kandels-Lewis,Tara Oceans Coordinators,Chris Bowler,Colomban de Vargas,Gabriel Gorsky,Nigel Grimsley,Pascal Hingamp,Daniele Iudicone,Olivier Jaillon,Fabrice Not,Hiroyuki Ogata,Stephane Pesant,Sabrina Speich,Lars Stemmann,Matthew B. Sullivan,Jean Weissenbach,Patrick Wincker,Eric Karsenti,Jeroen Raes,Silvia G. Acinas,Peer Bork +50 more
TL;DR: This work identifies ocean microbial core functionality and reveals that >73% of its abundance is shared with the human gut microbiome despite the physicochemical differences between these two ecosystems.
Journal ArticleDOI
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Patrik L. Ståhl,Patrik L. Ståhl,Fredrik Salmén,Sanja Vickovic,Anna Lundmark,Anna Lundmark,José Fernández Navarro,José Fernández Navarro,Jens P. Magnusson,Stefania Giacomello,Michaela Asp,Jakub Orzechowski Westholm,Mikael Huss,Annelie Mollbrink,Sten Linnarsson,Simone Codeluppi,Åke Borg,Fredrik Pontén,Paul I. Costea,Pelin Sahlén,Jan Mulder,Olaf Bergmann,Joakim Lundeberg,Jonas Frisén +23 more
TL;DR: By positioning histological sections on arrayed reverse transcription primers with unique positional barcodes, this work demonstrates high-quality RNA-sequencing data with maintained two-dimensional positional information from the mouse brain and human breast cancer.
Journal ArticleDOI
Environment dominates over host genetics in shaping human gut microbiota
Daphna Rothschild,Omer Weissbrod,Elad Barkan,Alexander Kurilshikov,Tal Korem,David Zeevi,Paul I. Costea,Anastasia Godneva,Iris N. Kalka,Noam Bar,Smadar Shilo,Dar Lador,Arnau Vich Vila,Niv Zmora,Niv Zmora,Meirav Pevsner-Fischer,David Israeli,Noa Kosower,Gal Malka,Bat Chen Wolf,Tali Avnit-Sagi,Maya Lotan-Pompan,Adina Weinberger,Zamir Halpern,Shai Carmi,Jingyuan Fu,Cisca Wijmenga,Cisca Wijmenga,Alexandra Zhernakova,Eran Elinav,Eran Segal +30 more
TL;DR: Genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment are examined, and it is demonstrated that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition.
Journal ArticleDOI
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
Kristoffer Forslund,Falk Hildebrand,Falk Hildebrand,Trine Nielsen,Gwen Falony,Gwen Falony,Shinichi Sunagawa,Edi Prifti,Sara Vieira-Silva,Sara Vieira-Silva,Valborg Gudmundsdottir,Helle Krogh Pedersen,Manimozhiyan Arumugam,Karsten Kristiansen,Anita Y. Voigt,Anita Y. Voigt,Henrik Vestergaard,Rajna Hercog,Paul I. Costea,Jens Roat Kultima,Junhua Li,Torben Jørgensen,Torben Jørgensen,Florence Levenez,Joël Doré,H. Bjørn Nielsen,Søren Brunak,Søren Brunak,Jeroen Raes,Jeroen Raes,Jeroen Raes,Torben Hansen,Torben Hansen,Jun Wang,S. Dusko Ehrlich,S. Dusko Ehrlich,Peer Bork,Oluf Pedersen +37 more
TL;DR: A unified signature of gut microbiome shifts in T2D with a depletion of butyrate-producing taxa is reported, highlighting the need to disentangle gut microbiota signatures of specific human diseases from those of medication.
Journal ArticleDOI
Potential of fecal microbiota for early‐stage detection of colorectal cancer
Georg Zeller,Julien Tap,Anita Y. Voigt,Shinichi Sunagawa,Jens Roat Kultima,Paul I. Costea,Aurelien Amiot,Jürgen Böhm,Francesco Brunetti,Nina Habermann,Rajna Hercog,Moritz Koch,Alain Luciani,Daniel R. Mende,Martin Schneider,Petra Schrotz-King,Christophe Tournigand,Jeanne Tran Van Nhieu,Takuji Yamada,Jürgen Zimmermann,Vladimir Benes,Matthias Kloor,Matthias Kloor,Matthias Kloor,Cornelia M. Ulrich,Cornelia M. Ulrich,Magnus von Knebel Doeberitz,Magnus von Knebel Doeberitz,Magnus von Knebel Doeberitz,Iradj Sobhani,Peer Bork,Peer Bork +31 more
TL;DR: CRC‐associated changes in the fecal microbiome at least partially reflected microbial community composition at the tumor itself, indicating that observed gene pool differences may reveal tumor‐related host–microbe interactions.