P
Per Hoffmann
Researcher at University of Basel
Publications - 286
Citations - 30547
Per Hoffmann is an academic researcher from University of Basel. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 60, co-authored 254 publications receiving 24161 citations. Previous affiliations of Per Hoffmann include University Hospital Bonn & Forschungszentrum Jülich.
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Journal ArticleDOI
Genome-wide CNV analysis in 221 unrelated patients and targeted high-throughput sequencing reveal novel causative candidate genes for colorectal adenomatous polyposis.
Sukanya Horpaopan,Isabel Spier,Alexander M. Zink,Janine Altmüller,Stefanie Holzapfel,Andreas Laner,Stefanie Vogt,Siegfried Uhlhaas,Stefanie Heilmann,Dietlinde Stienen,Sandra M. Pasternack,Kathleen Keppler,Ronja Adam,Katrin Kayser,Susanne Moebus,Markus Draaken,Franziska Degenhardt,Hartmut Engels,Andrea Hofmann,Markus M. Nöthen,Verena Steinke,Alberto Perez-Bouza,Stefan Herms,Elke Holinski-Feder,Holger Fröhlich,Holger Thiele,Per Hoffmann,Stefan Aretz +27 more
TL;DR: A group of rarely affected genes which are likely to predispose to colorectal adenoma formation are identified and previously published candidates for tumor predisposition as etiologically relevant are confirmed.
Journal ArticleDOI
The severity of human peri-implantitis lesions correlates with the level of submucosal microbial dysbiosis.
Annika Therese Kröger,Annika Therese Kröger,Claudia Hülsmann,Stefan Fickl,Thomas Spinell,Fabian Hüttig,Frederic Kaufmann,André Heimbach,Per Hoffmann,Per Hoffmann,Norbert Enkling,Stefan Renvert,Frank Schwarz,Ryan T. Demmer,Panos N. Papapanou,Søren Jepsen,Moritz Kebschull,Moritz Kebschull,Moritz Kebschull +18 more
TL;DR: Increases in peri-implant pocket depth are associated with substantial changes in the submucosal microbiome and increasing levels of dysbiosis, and two mutually exclusive complexes associated with shallow pockets and deeper pockets were identified.
Journal ArticleDOI
Common variation at 10p12.31 near MLLT10 influences meningioma risk
Sara E. Dobbins,Peter Broderick,Beatrice Melin,Maria Feychting,Christoffer Johansen,Ulrika Andersson,Thomas Brännström,J. Schramm,Bianca Olver,Amy Lloyd,Yussanne Ma,Fay J. Hosking,Stefan Lönn,Anders Ahlbom,Roger Henriksson,Roger Henriksson,Minouk J. Schoemaker,S. J. Hepworth,Per Hoffmann,Thomas W. Mühleisen,Markus M. Nöthen,Markus M. Nöthen,Susanne Moebus,Lewin Eisele,Michael Kosteljanetz,Kenneth Muir,Anthony J. Swerdlow,Matthias Simon,Richard S. Houlston +28 more
TL;DR: A new susceptibility locus for meningioma is identified at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, Pcombined =1.88 × 10−14).
Journal ArticleDOI
Novel genome-wide association study-based candidate loci for differentiated thyroid cancer risk.
Gisella Figlioli,Aleksandra Köhler,Bowang Chen,Rossella Elisei,Cristina Romei,Monica Cipollini,Alfonso Cristaudo,Franco Bambi,Elisa Paolicchi,Per Hoffmann,Per Hoffmann,Stefan Herms,Stefan Herms,Michał Kalemba,Dorota Kula,Susana Pastor,Susana Pastor,Ricard Marcos,Ricard Marcos,Antonia Velázquez,Antonia Velázquez,Barbara Jarząb,Stefano Landi,Kari Hemminki,Kari Hemminki,Asta Försti,Asta Försti,Federica Gemignani +27 more
TL;DR: The findings provide evidence for novel DTC susceptibility variants based on the GWAS and in silico analyses provided new insights into the possible functional consequences of the SNPs that showed the strongest association with DTC.
Journal ArticleDOI
Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci.
Matthias Munz,Matthias Munz,Gesa M. Richter,Bruno G. Loos,Søren Jepsen,Kimon Divaris,Steven Offenbacher,Alexander Teumer,Birte Holtfreter,Thomas Kocher,Corinna Bruckmann,Yvonne Jockel-Schneider,Christian Graetz,Ilyas Ahmad,Ingmar Staufenbiel,Nathalie van der Velde,André G. Uitterlinden,Lisette C. P. G. M. de Groot,Jürgen Wellmann,Klaus Berger,Bastian Krone,Per Hoffmann,Per Hoffmann,Matthias Laudes,Wolfgang Lieb,Andre Franke,Jeanette Erdmann,Henrik Dommisch,Arne S. Schaefer +28 more
TL;DR: This study identified novel risk loci of periodontitis, adding to the genetic basis of AgP and CP, which are thought to share risk alleles and predisposing environmental factors.