P
Per Hoffmann
Researcher at University of Basel
Publications - 286
Citations - 30547
Per Hoffmann is an academic researcher from University of Basel. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 60, co-authored 254 publications receiving 24161 citations. Previous affiliations of Per Hoffmann include University Hospital Bonn & Forschungszentrum Jülich.
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Journal ArticleDOI
Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder
Thomas W. Mühleisen,Manuel Mattheisen,Manuel Mattheisen,Jana Strohmaier,Franziska Degenhardt,Lutz Priebe,C. Christoph Schultz,René Breuer,Sandra Meier,Per Hoffmann,Fernando Rivandeneira,Fernando Rivandeneira,Albert Hofman,André G. Uitterlinden,André G. Uitterlinden,Susanne Moebus,Christian Gieger,Rebecca T. Emeny,Karl-Heinz Ladwig,H-Erich Wichmann,Markus J. Schwarz,Jutta Kammerer-Ciernioch,Ralf G.M. Schlösser,Igor Nenadic,Heinrich Sauer,Rainald Mössner,Wolfgang Maier,Dan Rujescu,Christoph Lange,Christoph Lange,Roel A. Ophoff,Roel A. Ophoff,Thomas G. Schulze,Marcella Rietschel,Markus M. Nöthen,Sven Cichon,Sven Cichon +36 more
TL;DR: The data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia and follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium provided further support.
Journal ArticleDOI
Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood
Roy Lardenoije,Roy Lardenoije,Janou A. Y. Roubroeks,Janou A. Y. Roubroeks,Ehsan Pishva,Ehsan Pishva,Markus Leber,Holger Wagner,Artemis Iatrou,Adam Smith,Rebecca G. Smith,Lars M. T. Eijssen,Luca Kleineidam,Luca Kleineidam,Luca Kleineidam,Amit Kawalia,Per Hoffmann,Per Hoffmann,Tobias Luck,Steffi G. Riedel-Heller,Frank Jessen,Frank Jessen,Wolfgang Maier,Wolfgang Maier,Michael Wagner,Michael Wagner,René Hurlemann,Gunter Kenis,Muhammad Ali,Muhammad Ali,Antonio del Sol,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Paul D. Coleman,Jonathan Mill,Jonathan Mill,Bart P. F. Rutten,Katie Lunnon,Alfredo Ramirez,Alfredo Ramirez,Daniel L.A. van den Hove,Daniel L.A. van den Hove +42 more
TL;DR: The implication of genome-wide significant differential methylation of OXT, encoding oxytocin, in two independent cohorts indicates it is a promising target for future studies on early biomarkers and novel therapeutic strategies in AD.
Journal ArticleDOI
TLR4, ATF-3 and IL8 inflammation mediator expression correlates with seizure frequency in human epileptic brain tissue.
Katharina Pernhorst,Stefan Herms,Stefan Herms,Per Hoffmann,Per Hoffmann,Sven Cichon,Sven Cichon,Sven Cichon,Herbert Schulz,Thomas Sander,Susanne Schoch,Albert J. Becker,Alexander Grote +12 more
TL;DR: A differential correlation of key inflammatory factor expression in epileptic hippocampi and seizure frequency in patients is suggested, which may open new therapeutic perspectives for treating seizures.
Posted ContentDOI
LAMP-Seq: Population-Scale COVID-19 Diagnostics Using a Compressed Barcode Space
Jonathan L. Schmid-Burgk,Ricarda Maria Schmithausen,David Li,Ronja Hollstein,Ronja Hollstein,Ronja Hollstein,Amir Ben-Shmuel,Ofir Israeli,Shay Weiss,Nir Paran,Gero Wilbring,Jana Liebing,David Feldman,Mikolaj Slabicki,Mikolaj Slabicki,Mikolaj Slabicki,Baerbel Lippke,Esther Sib,Jacob Borrajo,Jonathan Strecker,Julia Reinhardt,Per Hoffmann,Brian Cleary,Michael Hoelzel,Markus M. Noethen,Martin Exner,Kerstin U. Ludwig,Aviv Regev,Feng Zhang +28 more
TL;DR: A protocol for LAMP-Seq, a barcoded Reverse-Transcription Loop-mediated Isothermal Amplification (RT-LAMP) method that is highly scalable and relies on world-wide infrastructure for next-generation sequencing, and could be scaled to analyze millions of samples per day.
Journal ArticleDOI
Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma
Matthew Frampton,Miguel Inacio da Silva Filho,Peter Broderick,Hauke Thomsen,Asta Försti,Asta Försti,Jayaram Vijayakrishnan,Rosie Cooke,Victor Enciso-Mora,Per Hoffmann,Per Hoffmann,Markus M. Nöthen,Markus M. Nöthen,Amy Lloyd,Amy Holroyd,Lewin Eisele,Karl-Heinz Jöckel,Sabine Ponader,Elke Pogge von Strandmann,Tracy Lightfoot,Eve Roman,Annette Lake,Dorothy Montgomery,Ruth F. Jarrett,Anthony J. Swerdlow,Andreas Engert,Kari Hemminki,Richard S. Houlston +27 more
TL;DR: A GWAS meta-analysis with published GWASs identifies new HL susceptibility loci and maps intergenic to HBS1L and MYB, a region previously associated with hematopoiesis, and provides further insight into the genetic and biological basis of inherited susceptibility to HL.