M
Matthias Munz
Researcher at University of Lübeck
Publications - 39
Citations - 1266
Matthias Munz is an academic researcher from University of Lübeck. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 12, co-authored 37 publications receiving 774 citations. Previous affiliations of Matthias Munz include Humboldt University of Berlin & Braunschweig University of Technology.
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Journal ArticleDOI
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
Philip C Haycock,Stephen Burgess,Aayah Nounu,Jie Zheng,G N Okoli,Jack Bowden,Kaitlin H Wade,Nicholas J. Timpson,David M. Evans,Peter Willeit,Abraham Aviv,Tom R. Gaunt,Gibran Hemani,Massimo Mangino,Hayley P Ellis,Kathreena M Kurian,Karen A. Pooley,Rosalind A. Eeles,Jeffrey E. Lee,Shenying Fang,Wei V. Chen,Matthew Law,Lisa Bowdler,Mark M. Iles,Qiong Yang,Bradford B. Worrall,Hugh S. Markus,Rayjean J. Hung,Christopher I. Amos,Amanda B. Spurdle,Deborah J. Thompson,Tracy A. O'Mara,Brian M. Wolpin,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Antonia Trichopoulou,N. Charlotte Onland-Moret,Eiliv Lund,Eric J. Duell,Federico Canzian,Gianluca Severi,Kim Overvad,Marc J. Gunter,Rosario Tumino,Ulrika Svenson,Andre M. van Rij,Annette F. Baas,Matthew J. Bown,Nilesh J. Samani,Femke N G van t'Hof,Gerard Tromp,Gregory T. Jones,Helena Kuivaniemi,James R. Elmore,Mattias Johansson,James McKay,Ghislaine Scelo,Robert Carreras-Torres,Valerie Gaborieau,Paul Brennan,Paige M. Bracci,Rachel E. Neale,Sara H. Olson,Steven Gallinger,Donghui Li,Gloria M. Petersen,Harvey A. Risch,Alison P. Klein,Jiali Han,Christian C. Abnet,Neal D. Freedman,Philip R. Taylor,John M. Maris,Katja K.H. Aben,Lambertus A. Kiemeney,Sita H. Vermeulen,John K. Wiencke,Kyle M. Walsh,Margaret Wrensch,Terri Rice,Clare Turnbull,Kevin Litchfield,Lavinia Paternoster,Marie Standl,Gonçalo R. Abecasis,John Paul SanGiovanni,Yong Li,Vladan Mijatovic,Yadav Sapkota,Siew-Kee Low,Krina T. Zondervan,Grant W. Montgomery,Dale R. Nyholt,David A. van Heel,Karen A. Hunt,Dan E. Arking,Foram N. Ashar,Nona Sotoodehnia,Daniel Woo,Jonathan Rosand,Mary E. Comeau,W. Mark Brown,Edwin K. Silverman,John E. Hokanson,Michael H. Cho,Jennie Hui,Manuel A. R. Ferreira,Philip J. Thompson,Alanna C. Morrison,Janine F. Felix,Nicholas L. Smith,Angela M. Christiano,Lynn Petukhova,Regina C. Betz,Xing Fan,Xuejun Zhang,Caihong Zhu,Carl D. Langefeld,Susan D. Thompson,Feijie Wang,Xu Lin,David A. Schwartz,Tasha E. Fingerlin,Jerome I. Rotter,Mary Frances Cotch,Richard A. Jensen,Matthias Munz,Henrik Dommisch,Arne S. Schaefer,Fang Han,Hanna Ollila,Ryan P. Hillary,Omar M. E. Albagha,Stuart H. Ralston,Chenjie Zeng,Wei Zheng,Xiao-Ou Shu,André Reis,Steffen Uebe,Ulrike Hüffmeier,Yoshiya Kawamura,Takeshi Otowa,Tsukasa Sasaki,Martin L. Hibberd,Sonia Davila,Gang Xie,Katherine A. Siminovitch,Jin-Xin Bei,Yi Xin Zeng,Asta Försti,Bowang Chen,Stefano Landi,Andre Franke,Annegret Fischer,David Ellinghaus,Carlos Flores,Imre Noth,Shwu-Fan Ma,Jia Nee Foo,Jianjun Liu,Jong-Won Kim,David G. Cox,Olivier Delattre,Olivier Mirabeau,Christine F. Skibola,Clara S. Tang,Merce Garcia-Barcelo,Kai-Ping Chang,Wen-Hui Su,Yu-Sun Chang,Nicholas G. Martin,Scott D. Gordon,Tracey D. Wade,Chaeyoung Lee,Michiaki Kubo,Pei-Chieng Cha,Yusuke Nakamura,Daniel Levy,Masayuki Kimura,Shih-Jen Hwang,Steven C. Hunt,Tim D. Spector,Nicole Soranzo,Ani Manichaikul,R. Graham Barr,Bratati Kahali,Elizabeth K. Speliotes,Laura M. Yerges-Armstrong,Ching-Yu Cheng,Jost B. Jonas,Tien Yin Wong,Isabella Fogh,Kuang Lin,John Powell,Kenneth Rice,Caroline L Relton,Richard M. Martin,George Davey Smith +197 more
TL;DR: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases, as well as single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population.
Journal ArticleDOI
Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease
Steven Offenbacher,Kimon Divaris,Silvana P. Barros,Kevin Moss,Julie T. Marchesan,Thiago Morelli,Shaoping Zhang,Steven Kim,Lu Sun,James D. Beck,Matthias Laudes,Matthias Munz,Arne S. Schaefer,Kari E. North +13 more
TL;DR: Although not associated with current clinically determined periodontal disease taxonomies, upon replication and mechanistic validation these candidate loci may highlight dysbiotic microbial community structures and altered inflammatory/immune responses underlying biological sub-types of CP.
Journal ArticleDOI
A saturated map of common genetic variants associated with human height
Loic Yengo,Sailaja Vedantam,Eirini Marouli,Julia Sidorenko,Eric Bartell,Saori Sakaue,Marielisa Graff,Anders U. Eliasen,Yunxuan Jiang,Sridharan Raghavan,Jenkai Miao,Joshua Daniel Arias,Ronen E. Mukamel,Cassandra N. Spracklen,Xianyong Yin,Shyh-Huei Chen,Teresa Ferreira,JI Yingjie,Kreete Lüll,Kuang Lin,Deborah E. Malden,Carolina Medina-Gomez,Moara Machado,Amy Moore,Sina Rüeger,Tarunveer S. Ahluwalia,Masato Akiyama,Matthew A. Allison,Marcus Alvarez,Mette K. Andersen,Alireza Ani,Vivek Appadurai,Liubov Arbeeva,Seema Bhaskar,Lawrence F. Bielak,Sailalitha Bollepalli,Lori L. Bonnycastle,Jette Bork-Jensen,Jonathan P. Bradfield,Yuki Bradford,Peter S. Braund,Jennifer A. Brody,Kristoffer Sølvsten Burgdorf,Brian E. Cade,Hui Cai,Qiuyin Cai,Archie Campbell,Marisa Cañadas-Garre,Eulalia Catamo,Jin-Fang Chai,Xiaoran Chai,Li Chang,Yipeng Chang,Chien-Hsiun Chen,Alessandra Chesi,Seung Hoan Choi,Ren-Hua Chung,Massimiliano Cocca,Maria Pina Concas,Christian Couture,Gabriel Cuellar-Partida,Rebecca D Danning,E. Warwick Daw,Frauke Degenhard,Graciela E. Delgado,Alessandro P Delitala,Ayse Demirkan,Xuan Deng,Poornima Devineni,Alexander Dietl,Maria Dimitriou,Latchezar Dimitrov,Rajkumar Dorajoo,Arif B. Ekici,Jorgen Engmann,Zammy Fairhurst-Hunter,Aliki-Eleni Farmaki,Jessica D. Faul,Juan Carlos Fernández-López,Lukas Forer,Margherita Francescatto,Sandra Freitag-Wolf,Christian Fuchsberger,Tessel E. Galesloot,Yan Gao,Zishan Gao,Frank Geller,Olga Giannakopoulou,Franco Giulianini,Anette P. Gjesing,Anuj Goel,Scott D. Gordon,Mathias Gorski,Sarah E. Graham,Jakob Grove,Xiuqing Guo,Stefan Gustafsson,Jeffrey Haessler,Thomas Hansen,Aki S. Havulinna,Simon Haworth,Jiang He,Nancy L. Heard-Costa,Prashantha Hebbar,George Hindy,Yuk-Lam Ho,Edith Hofer,Elizabeth G. Holliday,Katrin Horn,Whitney E. Hornsby,Jouke-Jan Hottenga,Hongyan Huang,Jie Huang,Alicia Huerta-Chagoya,Jennifer E. Huffman,Yi Jen Hung,Shaofeng Huo,Mi Yeong Hwang,H. Iha,Daisuke Ikeda,Masato Isono,Anne U. Jackson,Susanne Jäger,Iris E. Jansen,Ingegerd Johansson,Jost B. Jonas,Anna Jonsson,Torben Jørgensen,Ioanna P. Kalafati,Masahiro Kanai,Stavroula Kanoni,Line Lund Kårhus,Anuradhani Kasturiratne,Tomohiro Katsuya,Takahisa Kawaguchi,Rachel L. Kember,Katherine A. Kentistou,Han Na Kim,Young-Jin Kim,Marcus E. Kleber,Maria J. Knol,Azra Kurbasic,Marie Lauzon,Phuong Le,Rod A. Lea,Jong-Young Lee,Hampton L. Leonard,Shengchao A. Li,Xiaohui Li,Xiaoyin Li,Jin Liang,Honghuang Lin,Shih-Yi Lin,Jun Liu,Xueping Liu,Ken Sin Lo,Jirong Long,Laura Lorés-Motta,Jian'an Luan,Valeriya Lyssenko,Leo-Pekka Lyytikäinen,Anubha Mahajan,Vasiliki Mamakou,Massimo Mangino,Ani Manichaikul,Jonathan Marten,Manuel Mattheisen,L. Mavarani,Aaron McDaid,Karina Meidtner,Tori L. Melendez,Josep M. Mercader,Yuri Milaneschi,Jason E. Miller,Iona Y. Millwood,Pashupati P. Mishra,Ruth Mitchell,Line Tang Møllehave,Anna Morgan,Soeren Mucha,Matthias Munz,Masahiro Nakatochi,Christopher P. Nelson,Maria Nethander,Chu Won Nho,Aneta Aleksandra Nielsen,Ilja M. Nolte,Suraj S. Nongmaithem,Raymond Noordam,Ioanna Ntalla,Teresa Nutile,Anita Pandit,Paraskevi Christofidou,Katri Pärna,Marc Pauper,Eva R. B. Petersen,Liselotte Petersen,Niina Pitkänen,Ozren Polasek,Alaitz Poveda,Michael Preuss,Saiju Pyarajan,Laura M. Raffield,Hiromi Rakugi,Julia Ramirez,Asif Rasheed,Dennis Raven,Nigel W. Rayner,Carlos Riveros,Rebecca Rohde,Daniela Ruggiero,Sanni Ruotsalainen,Kathleen A. Ryan,Maria Sabater-Lleal,Richa Saxena,Markus Scholz,Anoop K. Sendamarai,Botong Shen,Jingchunzi Shi,Jae Hun Shin,Carlo Sidore,Xueling Sim,Colleen M. Sitlani,Roderick C. Slieker,Roelof A.J. Smit,Jennifer A. Smith,Laura Smyth,Lorraine Southam,Valgerdur Steinthorsdottir,Liangdan Sun,Fumihiko Takeuchi,Divya Sri Priyanka Tallapragada,Kent D. Taylor,Bamidele O. Tayo,Catherine Tcheandjieu,Natalie Terzikhan,Paola Tesolin,Alexander Teumer,Elizabeth Theusch,Deborah J. Thompson,Gudmar Thorleifsson,Paul R. H. J. Timmers,Stella Trompet,Constance Turman,Simona Vaccargiu,Sander W. van der Laan,Peter J. van der Most,Jan B. van Klinken,Jessica van Setten,Shefali S. Verma,Niek Verweij,Yogasudha Veturi,Carol A. Wang,Chaolong Wang,Lihua Wang,Zhe Wang,Helen R. Warren,Wenjie Wei,Ananda R. Wickremasinghe,Matthias Wielscher,Kerri L. Wiggins,Bendik S. Winsvold,Andrew Wong,Yang Wu,Matthias Wuttke,Rong Xi,Tian Xie,Ken Yamamoto,Jingyun Yang,Jie Yao,Hannah Young,Noha A. Yousri,Lingyao Zeng,Weihua Zhang,Xinyuan Zhang,Jing Hua Zhao,Wei Zhao,Wei Zhou,Martina E. Zimmermann,Magdalena Zoledziewska,Linda S. Adair,Hieab H.H. Adams,Carlos A. Aguilar-Salinas,Fahd Al-Mulla,Donna K. Arnett,Folkert W. Asselbergs,Bjørn Olav Åsvold,John Attia,Bernhard Banas,Stefania Bandinelli,David A. Bennett,Tobias Bergler,Dwaipayan Bharadwaj,Ginevra Biino,Hans Bisgaard,Eric Boerwinkle,Carsten A. Böger,Klaus Bønnelykke,Dorret I. Boomsma,Anders D. Børglum,Judith B. Borja,Claude Bouchard,Donald W. Bowden,Ivan Brandslund,Ben Michael Brumpton,Julie E. Buring,Mark J. Caulfield,John C. Chambers,Giriraj R. Chandak,Stephen J. Chanock,Nish Chaturvedi,Yii-Der Ida Chen,Zhengming Chen,Ching-Yu Cheng,Ingrid E. Christophersen,Marina Ciullo,John W. Cole,Francis S. Collins,Richard S. Cooper,Miguel Cruz,Francesco Cucca,L. Adrienne Cupples,Michael J. Cutler,Scott M. Damrauer,Thomas Meinertz Dantoft,Gert J. de Borst,Lisette C. P. G. M. de Groot,Philip L. De Jager,Dominique P.V. de Kleijn,H. Janaka de Silva,George Dedoussis,Anneke I. den Hollander,Shufa Du,Douglas F. Easton,Petra J. M. Elders,A. Heather Eliassen,Patrick T. Ellinor,Sölve Elmståhl,Jeanette Erdmann,Michele K. Evans,Diane Fatkin,Bjarke Feenstra,Mary F. Feitosa,Luigi Ferrucci,Ian Ford,Myriam Fornage,Andre Franke,Paul W. Franks,Barry I. Freedman,Paolo Gasparini,Christian Gieger,Giorgia Girotto,Michael E. Goddard,Yvonne M. Golightly,Clicerio González-Villalpando,Penny Gordon-Larsen,Harald Grallert,Struan F.A. Grant,Niels Grarup,Lyn R. Griffiths,Leif Groop,Vilmundur Gudnason,Christopher A. Haiman,Hakon Hakonarson,Torben Hansen,Catharina A. Hartman,Andrew T. Hattersley,Caroline Hayward,Susan R. Heckbert,Chew-Kiat Heng,Christian Hengstenberg,Alex W. Hewitt,Haretsugu Hishigaki,Carel B. Hoyng,Paul L. Huang,Wei Huang,Steven C. Hunt,Kristian Hveem,Elina Hyppönen,William G. Iacono,Sahoko Ichihara,M. Arfan Ikram,Carmen R. Isasi,Rebecca D. Jackson,Marjo-Ritta Jarvelin,Zidan Jin,Karl-Heinz Jöckel,Peter K. Joshi,Pekka Jousilahti,J. Wouter Jukema,Mika Kähönen,Yoichiro Kamatani,Kui Dong Kang,Jaakko Kaprio,Sharon L.R. Kardia,Fredrik Karpe,Norihiro Kato,Frank Kee,Thorsten Kessler,Amit Khera,Chiea Chuen Khor,Lambertus A. Kiemeney,Bong-Jo Kim,EunGyul Kim,Hyung Lae Kim,Paulus Kirchhof,M Kivimaki,Woon-Puay Koh,Heikki A. Koistinen,Genovefa Kolovou,Jaspal S. Kooner,Charles Kooperberg,Anna Köttgen,Peter Kovacs,Adriaan O. Kraaijeveld,Peter Kraft,R. Krauß,Meena Kumari,Zoltán Kutalik,Markku Laakso,Leslie A. Lange,Claudia Langenberg,Lenore J. Launer,Loic Le Marchand,Hye Jin Lee,Nanette R. Lee,Terho Lehtimäki,Huaixing Li,Liming Li,Wolfgang Liebig,Xu（林旭） Lin,Lars Lind,Allan Linneberg,Ching-Ti Liu,Jianjun Liu,Markus Loeffler,Barry London,Steven A. Lubitz,Stephen J. Lye,David A. Mackey,Reedik Mägi,Patrik K. E. Magnusson,Gregory M. Marcus,Pedro Marques Vidal,Nicholas G. Martin,Winfried März,Fumihiko Matsuda,Robert W. McGarrah,Matt McGue,Amy Jayne McKnight,Sarah E. Medland,Dan Mellström,Andres Metspalu,Braxton D. Mitchell,Paul Mitchell,Dennis O. Mook-Kanamori,Andrew D. Morris,Lorelei A. Mucci,Patricia B. Munroe,Mike A. Nalls,Saman Nazarian,Amanda E. Nelson,Matt Neville,Christopher Newton-Cheh,Christopher Sivert Nielsen,Markus M. Nöthen,Claes Ohlsson,Albertine J. Oldehinkel,Lorena Orozco,Katja Pahkala,Päivi Pajukanta,Colin N. A. Palmer,Esteban J. Parra,Cristian Pattaro,Oluf Pedersen,Craig E. Pennell,Brenda W.J.H. Penninx,Louis Pérusse,Annette Peters,Patricia A. Peyser,David J. Porteous,Danielle Posthuma,Chris Power,Peter P. Pramstaller,Michael A. Province,Qibin Qi,Jia Qu,Daniel J. Rader,Olli T. Raitakari,Sarju Ralhan,Loukianos S. Rallidis,Dabeeru C. Rao,Susan Redline,Dermot F. Reilly,Alexander P. Reiner,Sang Youl Rhee,Paul M. Ridker,Michiel Rienstra,Samuli Ripatti,Marylyn D. Ritchie,Dan M. Roden,Frits R. Rosendaal,Jerome I. Rotter,Igor Rudan,Femke Rutters,Charumathi Sabanayagam,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Dharambir K. Sanghera,Naveed Sattar,Börge Schmidt,E. E. Schmidt,Reinhold Schmidt,Matthias B. Schulze,Heribert Schunkert,Laura J. Scott,Rodney J. Scott,Peter S. Sever,Eric J. Shiroma,M. Benjamin Shoemaker,Xiao-Ou Shu,Eleanor M. Simonsick,Mario Sims,Jai Rup Singh,Andrew B. Singleton,Moritz F. Sinner,J. Gustav Smith,Harold Snieder,Tim D. Spector,Meir J. Stampfer,Klaus Stark,David P. Strachan,Leen M 't Hart,Yasuharu Tabara,Hua Tang,Jean-Claude Tardif,Thangavel Alphonse Thanaraj,Nicholas J. Timpson,Anke Tönjes,Angelo Tremblay,Tiinamaija Tuomi,Jaakko Tuomilehto,María Teresa Tusié-Luna,André G. Uitterlinden,Rob M. van Dam,P. Van der Harst,Nathalie van der Velde,Cornelia M. van Duijn,Natasja M. van Schoor,Veronique Vitart,Uwe Völker,Peter Vollenweider,Henry Völzke,Scott I. Vrieze,Niels Wacher-Rodarte,Mark Walker,Ya Xing Wang,Nicholas J. Wareham,Richard M. Watanabe,Hugh Watkins,David R. Weir,Thomas Werge,Elisabeth Widen,Lynne R. Wilkens,Gonneke Willemsen,Walter C. Willett,James F. Wilson,Tien Yin Wong,Jeong Taek Woo,Alan F. Wright,Jer-Yuarn Wu,Huichun Xu,Chittaranjan S. Yajnik,Mitsuhiro Yokota,Jian-Min Yuan,Eleftheria Zeggini,Babette S. Zemel,Wei Zheng,Xiaofeng Zhu,Joseph M. Zmuda,Alan B. Zonderman,John-Anker Zwart,Daniel I. Chasman,Yoon Shin Cho,Iris M. Heid,Mark I. McCarthy,Maggie C.Y. Ng,Christopher J. O'Donnell,Fernando Rivadeneira,Unnur Thorsteinsdottir,Yan V. Sun,E. Shyong Tai,Michael Boehnke,Panos Deloukas,Anne E. Justice,Cecilia M. Lindgren,Ruth J. F. Loos,Karen L. Mohlke,Kari E. North,Kari Stefansson,Robin G. Walters,Thomas W. Winkler,Kristin L. Young,Po-ru Loh,Tõnu Esko,Themistocles L. Assimes,Adam Auton,Gonçalo R. Abecasis,Cristen J. Willer,Adam E. Locke,Sonja I. Berndt,Guillaume Lettre,Timothy M. Frayling,Yukinori Okada,Andrew R. Wood,Peter M. Visscher,Joel N. Hirschhorn +617 more
TL;DR: In this article , the authors show that common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes.
Journal ArticleDOI
A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis.
Matthias Munz,Christina Willenborg,Gesa M. Richter,Yvonne Jockel-Schneider,Christian Graetz,Ingmar Staufenbiel,Jürgen Wellmann,Klaus Berger,Bastian Krone,Per Hoffmann,Per Hoffmann,Nathalie van der Velde,André G. Uitterlinden,Lisette C P G M de Groot,Amr H. Sawalha,Haner Direskeneli,Güher Saruhan-Direskeneli,Esra Guzeldemir-Akcakanat,Huseyin Gencay Keceli,Matthias Laudes,Barbara Noack,Alexander Teumer,Birte Holtfreter,Thomas Kocher,Peter Eickholz,Jörg Meyle,Christof Doerfer,Corinna Bruckmann,Wolfgang Lieb,Andre Franke,Stefan Schreiber,Rahime M. Nohutcu,Jeanette Erdmann,Bruno G. Loos,S. Jepsen,Henrik Dommisch,Arne S. Schaefer +36 more
TL;DR: This study identifies the first shared genetic risk loci of AgP and CP with genome‐wide significance and highlights the role of innate and adaptive immunity in the etiology of periodontitis.
Journal ArticleDOI
Associations of autozygosity with a broad range of human phenotypes
David W. Clark,Yukinori Okada,Kristjan H. S. Moore,Dan Mason,Nicola Pirastu,Ilaria Gandin,Ilaria Gandin,Hannele Mattsson,Hannele Mattsson,Catriona L. K. Barnes,Kuang Lin,Jing Hua Zhao,Patrick Deelen,Rebecca Rohde,Claudia Schurmann,Xiuqing Guo,Franco Giulianini,Weihua Zhang,Weihua Zhang,Carolina Medina-Gomez,Robert Karlsson,Yanchun Bao,Traci M. Bartz,Clemens Baumbach,Ginevra Biino,Matthew J. Bixley,Marco Brumat,Jin-Fang Chai,Tanguy Corre,Tanguy Corre,Diana L. Cousminer,Annelot M. Dekker,David Eccles,David Eccles,Kristel R van Eijk,Christian Fuchsberger,He Gao,Marine Germain,Marine Germain,Scott D. Gordon,Hugoline G. de Haan,Sarah E. Harris,Edith Hofer,Alicia Huerta-Chagoya,Catherine Igartua,Iris E. Jansen,Iris E. Jansen,Yucheng Jia,Tim Kacprowski,Tim Kacprowski,Torgny Karlsson,Marcus E. Kleber,Shengchao Alfred Li,Ruifang Li-Gao,Anubha Mahajan,Koichi Matsuda,Karina Meidtner,Weihua Meng,May E. Montasser,Peter J. van der Most,Matthias Munz,Teresa Nutile,Teemu Palviainen,Gauri Prasad,Rashmi B. Prasad,Tallapragada Divya Sri Priyanka,Federica Rizzi,Erika Salvi,Erika Salvi,Bishwa Raj Sapkota,Daniel Shriner,Line Skotte,Melissa C. Smart,Albert V. Smith,Ashley van der Spek,Cassandra N. Spracklen,Rona J. Strawbridge,Rona J. Strawbridge,Salman M. Tajuddin,Stella Trompet,Constance Turman,Niek Verweij,Clara Viberti,Lihua Wang,Helen R. Warren,Robyn E Wootton,Lisa R. Yanek,Jie Yao,Noha A. Yousri,Noha A. Yousri,Wei Zhao,Adebowale Adeyemo,Saima Afaq,Carlos A. Aguilar-Salinas,Masato Akiyama,Matthew L. Albert,Matthew A. Allison,Maris Alver,Tin Aung,Fereidoun Azizi,Amy R. Bentley,Heiner Boeing,Eric Boerwinkle,Judith B. Borja,Gert J. de Borst,Erwin P. Bottinger,Erwin P. Bottinger,Linda Broer,Harry Campbell,Stephen J. Chanock,Miao-Li Chee,Guanjie Chen,Yii-Der Ida Chen,Zhengming Chen,Yen-Feng Chiu,Massimiliano Cocca,Francis S. Collins,Maria Pina Concas,Janie Corley,Giovanni Cugliari,Rob M. van Dam,Rob M. van Dam,Anna Damulina,Maryam S. Daneshpour,Felix R. Day,Graciela E. Delgado,Klodian Dhana,Klodian Dhana,Klodian Dhana,Alex S. F. Doney,Marcus Dörr,Ayo P. Doumatey,Nduna Dzimiri,S. Sunna Ebenesersdóttir,S. Sunna Ebenesersdóttir,Joshua Elliott,Paul Elliott,Ralf Ewert,Janine F. Felix,Krista Fischer,Barry I. Freedman,Giorgia Girotto,Anuj Goel,Martin Gögele,Mark O. Goodarzi,Mariaelisa Graff,Einat Granot-Hershkovitz,Francine Grodstein,Simonetta Guarrera,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Kamran Guity,Bjarni Gunnarsson,Yu Guo,Saskia P. Hagenaars,Saskia P. Hagenaars,Christopher A. Haiman,Avner Halevy,Tamara B. Harris,Mehdi Hedayati,David A. van Heel,Makoto Hirata,Imo Hofer,Chao A. Hsiung,Jinyan Huang,Yi-Jen Hung,Yi-Jen Hung,M. Arfan Ikram,Anuradha Jagadeesan,Anuradha Jagadeesan,Pekka Jousilahti,Yoichiro Kamatani,Masahiro Kanai,Masahiro Kanai,Nicola D. Kerrison,Thorsten Kessler,Kay-Tee Khaw,Chiea Chuen Khor,Chiea Chuen Khor,Dominique P.V. de Kleijn,Woon-Puay Koh,Ivana Kolcic,Peter Kraft,Bernhard K. Krämer,Zoltán Kutalik,Zoltán Kutalik,Johanna Kuusisto,Claudia Langenberg,Lenore J. Launer,Debbie A Lawlor,I-Te Lee,I-Te Lee,Wen-Jane Lee,Markus M. Lerch,Liming Li,Jianjun Liu,Jianjun Liu,Marie Loh,Marie Loh,Marie Loh,Stephanie J. London,Stephanie J. Loomis,Yingchang Lu,Jian'an Luan,Reedik Mägi,Ani Manichaikul,Paolo Manunta,Gisli Masson,Nana Matoba,Xue W. Mei,Christa Meisinger,Thomas Meitinger,Massimo Mezzavilla,Lili Milani,Iona Y Millwood,Yukihide Momozawa,Amy Moore,Pierre-Emmanuel Morange,Hortensia Moreno-Macías,Trevor A. Mori,Alanna C. Morrison,Taulant Muka,Taulant Muka,Yoshinori Murakami,Alison D. Murray,Renée de Mutsert,Josyf C. Mychaleckyj,Mike A. Nalls,Matthias Nauck,Matt J. Neville,Matt J. Neville,Ilja M. Nolte,Ken K. Ong,Lorena Orozco,Sandosh Padmanabhan,Gunnar K. Pálsson,James S. Pankow,Cristian Pattaro,Alison Pattie,Ozren Polasek,Neil Poulter,Peter P. Pramstaller,Lluis Quintana-Murci,Lluis Quintana-Murci,Katri Räikkönen,Sarju Ralhan,Dabeeru C. Rao,Wouter van Rheenen,Stephen S. Rich,Paul M. Ridker,Paul M. Ridker,Cornelius A. Rietveld,Antonietta Robino,Frank J. A. van Rooij,Daniela Ruggiero,Yasaman Saba,Charumathi Sabanayagam,Maria Sabater-Lleal,Cinzia Sala,Veikko Salomaa,Kevin Sandow,Helena Schmidt,Laura J. Scott,William R. Scott,Bahareh Sedaghati-khayat,Bengt Sennblad,Bengt Sennblad,Jessica van Setten,Peter S. Sever,Wayne Huey-Herng Sheu,Yuan Shi,Smeeta Shrestha,Smeeta Shrestha,Sharvari Rahul Shukla,Jon K. Sigurdsson,Timo Tõnis Sikka,Jai Rup Singh,Blair H. Smith,Alena Stančáková,Alice Stanton,John M. Starr,Lilja Stefansdottir,Leon Straker,Patrick Sulem,Gardar Sveinbjornsson,Morris A. Swertz,Adele M. Taylor,Kent D. Taylor,Natalie Terzikhan,Natalie Terzikhan,Yih Chung Tham,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Annika Tillander,Russell P. Tracy,Teresa Tusié-Luna,Ioanna Tzoulaki,Ioanna Tzoulaki,Simona Vaccargiu,Jagadish Vangipurapu,Jan H. Veldink,Veronique Vitart,Uwe Völker,Eero Vuoksimaa,Salma M. Wakil,Melanie Waldenberger,Gurpreet Singh Wander,Ya Xing Wang,Nicholas J. Wareham,Sarah H. Wild,Chittaranjan S. Yajnik,Jian-Min Yuan,Lingyao Zeng,Liang Zhang,Jie Zhou,Najaf Amin,Folkert W. Asselbergs,Stephan J. L. Bakker,Diane M. Becker,Benjamin Lehne,David A. Bennett,Leonard H. van den Berg,Sonja I. Berndt,Dwaipayan Bharadwaj,Lawrence F. Bielak,Murielle Bochud,Michael Boehnke,Claude Bouchard,Jonathan P. Bradfield,Jennifer A. Brody,Archie Campbell,Shai Carmi,Mark J. Caulfield,David Cesarini,John C. Chambers,Giriraj R. Chandak,Ching-Yu Cheng,Marina Ciullo,Marilyn C. Cornelis,Daniele Cusi,Daniele Cusi,George Davey Smith,Ian J. Deary,Rajkumar Dorajoo,Cornelia M. van Duijn,Cornelia M. van Duijn,David Ellinghaus,Jeanette Erdmann,Johan G. Eriksson,Evangelos Evangelou,Evangelos Evangelou,Michele K. Evans,Jessica D. Faul,Bjarke Feenstra,Mary F. Feitosa,Sylvain Foisy,Andre Franke,Yechiel Friedlander,Paolo Gasparini,Christian Gieger,Clicerio Gonzalez,Philippe Goyette,Struan F.A. Grant,Lyn R. Griffiths,Leif Groop,Leif Groop,Vilmundur Gudnason,Ulf Gyllensten,Hakon Hakonarson,Anders Hamsten,Pim van der Harst,Chew-Kiat Heng,Chew-Kiat Heng,Andrew A. Hicks,Hagit Hochner,Heikki V. Huikuri,Steven C. Hunt,Steven C. Hunt,Vincent W. V. Jaddoe,Philip L. De Jager,Philip L. De Jager,Magnus Johannesson,Åsa Johansson,Jost B. Jonas,Jost B. Jonas,J. Wouter Jukema,Juhani Junttila,Jaakko Kaprio,Sharon L.R. Kardia,Fredrik Karpe,Fredrik Karpe,Meena Kumari,Markku Laakso,Sander W. van der Laan,Jari Lahti,Matthias Laudes,Rodney A. Lea,Wolfgang Lieb,Thomas Lumley,Nicholas G. Martin,Winfried März,Winfried März,Giuseppe Matullo,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Sarah E. Medland,Tony R. Merriman,Andres Metspalu,Brian F. Meyer,Karen L. Mohlke,Grant W. Montgomery,Grant W. Montgomery,Dennis O. Mook-Kanamori,Patricia B. Munroe,Kari E. North,Dale R. Nyholt,Dale R. Nyholt,Jeffery R. O'Connell,Carole Ober,Albertine J. Oldehinkel,Walter Palmas,Colin N. A. Palmer,Gerard Pasterkamp,Etienne Patin,Etienne Patin,Craig E. Pennell,Craig E. Pennell,Louis Pérusse,Patricia A. Peyser,Mario Pirastu,Tinca J. C. Polderman,David J. Porteous,Danielle Posthuma,Bruce M. Psaty,Bruce M. Psaty,John D. Rioux,John D. Rioux,Fernando Rivadeneira,Charles N. Rotimi,Jerome I. Rotter,Igor Rudan,Hester M. den Ruijter,Dharambir K. Sanghera,Naveed Sattar,Reinhold Schmidt,Matthias B. Schulze,Heribert Schunkert,Robert A. Scott,Alan R. Shuldiner,Alan R. Shuldiner,Xueling Sim,Neil Small,Jennifer A. Smith,Nona Sotoodehnia,E-Shyong Tai,Alexander Teumer,Nicholas J. Timpson,Daniela Toniolo,David-Alexandre Trégouët,Tiinamaija Tuomi,Peter Vollenweider,Carol A. Wang,Carol A. Wang,David R. Weir,John Whitfield,Cisca Wijmenga,Tien Yin Wong,John Wright,Jingyun Yang,Lei Yu,Babette S. Zemel,Alan B. Zonderman,Markus Perola,Patrik K. E. Magnusson,André G. Uitterlinden,Jaspal S. Kooner,Daniel I. Chasman,Daniel I. Chasman,Ruth J. F. Loos,Ruth J. F. Loos,Nora Franceschini,Lude Franke,Chris Haley,Caroline Hayward,Robin G. Walters,John R. B. Perry,T Esko,T Esko,Agnar Helgason,Agnar Helgason,Kari Stefansson,Kari Stefansson,Peter K. Joshi,Michiaki Kubo,James F. Wilson +496 more
TL;DR: In this paper, the authors used genomic inbreeding coefficients (FROH) for >1.4 million individuals and found that FROH is significantly associated with apparently deleterious changes in 32 out of 100 traits analysed.