T
Tino Prell
Researcher at University of Jena
Publications - 119
Citations - 2511
Tino Prell is an academic researcher from University of Jena. The author has contributed to research in topics: Medicine & Amyotrophic lateral sclerosis. The author has an hindex of 22, co-authored 91 publications receiving 1850 citations. Previous affiliations of Tino Prell include Schiller International University & Otto-von-Guericke University Magdeburg.
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Journal ArticleDOI
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
Wouter van Rheenen,Aleksey Shatunov,Annelot M. Dekker,Russell L. McLaughlin,Frank P. Diekstra,Sara L. Pulit,Rick A.A. van der Spek,Urmo Võsa,Simone de Jong,Simone de Jong,Matthew R. Robinson,Jian Yang,Isabella Fogh,Isabella Fogh,Perry T.C. van Doormaal,Gijs H.P. Tazelaar,Max Koppers,Anna M. Blokhuis,William Sproviero,Ashley R. Jones,Kevin P. Kenna,Kristel R. van Eijk,Oliver Harschnitz,Raymond D. Schellevis,William J. Brands,Jelena Medic,Androniki Menelaou,Alice Vajda,Alice Vajda,Nicola Ticozzi,Kuang Lin,Boris Rogelj,Katarina Vrabec,Metka Ravnik-Glavač,Blaž Koritnik,Janez Zidar,Lea Leonardis,Leja Dolenc Grošelj,Stéphanie Millecamps,François Salachas,Vincent Meininger,Mamede de Carvalho,Susana Pinto,Jesus S. Mora,Ricardo Rojas-García,Meraida Polak,Siddharthan Chandran,Shuna Colville,Robert Swingler,Karen E. Morrison,Pamela J. Shaw,John Hardy,Richard W. Orrell,Alan M. Pittman,Katie Sidle,Pietro Fratta,Andrea Malaspina,Simon Topp,Susanne Petri,Susanne Abdulla,Carsten Drepper,Michael Sendtner,Thomas F. Meyer,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Kim A. Staats,Martina Wiedau-Pazos,Catherine Lomen-Hoerth,Vivianna M. Van Deerlin,John Q. Trojanowski,Lauren Elman,Leo McCluskey,A. Nazli Basak,Ceren Tunca,Hamid Hamzeiy,Yesim Parman,Thomas Meitinger,Peter Lichtner,Milena Radivojkov-Blagojevic,Christian R. Andres,Cindy Maurel,Gilbert Bensimon,Bernhard Landwehrmeyer,Alexis Brice,Christine Payan,Safaa Saker-Delye,Alexandra Durr,Nicholas W. Wood,Lukas Tittmann,Wolfgang Lieb,Andre Franke,Marcella Rietschel,Sven Cichon,Markus M. Nöthen,Philippe Amouyel,Christophe Tzourio,Jean-François Dartigues,André G. Uitterlinden,Fernando Rivadeneira,Karol Estrada,Albert Hofman,Albert Hofman,Charles Curtis,Charles Curtis,Hylke M. Blauw,Anneke J. van der Kooi,Marianne de Visser,An Goris,Markus Weber,Christopher Shaw,Bradley N. Smith,Orietta Pansarasa,Cristina Cereda,Roberto Del Bo,Giacomo P. Comi,Sandra D'Alfonso,Cinzia Bertolin,Gianni Sorarù,Letizia Mazzini,Viviana Pensato,Cinzia Gellera,Cinzia Tiloca,Antonia Ratti,Andrea Calvo,Cristina Moglia,Maura Brunetti,Simona Arcuti,Rosa Capozzo,Chiara Zecca,Christian Lunetta,Silvana Penco,Nilo Riva,Alessandro Padovani,Massimiliano Filosto,Bernard Muller,Robbert Jan Stuit,Ian P. Blair,Katharine Y. Zhang,Emily P. McCann,Jennifer A. Fifita,Garth A. Nicholson,Garth A. Nicholson,Dominic B. Rowe,Roger Pamphlett,Matthew C. Kiernan,Julian Grosskreutz,Otto W. Witte,Thomas M. Ringer,Tino Prell,Beatrice Stubendorff,Ingo Kurth,Christian A. Hübner,P. Nigel Leigh,Federico Casale,Adriano Chiò,Ettore Beghi,Elisabetta Pupillo,Rosanna Tortelli,Giancarlo Logroscino,John Powell,Albert C. Ludolph,Jochen H. Weishaupt,Wim Robberecht,Philip Van Damme,Lude Franke,Tune H. Pers,Robert H. Brown,Jonathan D. Glass,John Landers,Orla Hardiman,Orla Hardiman,Peter M. Andersen,Peter M. Andersen,Philippe Corcia,Patrick Vourc'h,Vincenzo Silani,Naomi R. Wray,Peter M. Visscher,Paul I.W. de Bakker,Michael A. van Es,R. Jeroen Pasterkamp,Cathryn M. Lewis,Gerome Breen,Gerome Breen,Ammar Al-Chalabi,Leonard H. van den Berg,Jan H. Veldink +187 more
TL;DR: Evidence of ALS being a complex genetic trait with a polygenic architecture is established and the SNP-based heritability is estimated at 8.5%, with a distinct and important role for low-frequency variants (frequency 1–10%).
Journal ArticleDOI
Acute Cerebrovascular Disease in the Young The Stroke in Young Fabry Patients Study
Arndt Rolfs,Franz Fazekas,Ulrike Grittner,Martin Dichgans,Peter Martus,Martin Holzhausen,Tobias Böttcher,Peter U. Heuschmann,Turgut Tatlisumak,Christian Tanislav,Gerhard J. Jungehulsing,Anne-Katrin Giese,Jukaa Putaala,Roman Huber,Ulf Bodechtel,Christoph Lichy,Christian Enzinger,Reinhold Schmidt,Michael G. Hennerici,Manfred Kaps,Christof Kessler,Karl Lackner,Eduard Paschke,Wolfgang Meyer,Hermann Mascher,Olaf Riess,Edwin Kolodny,Bo Norrving,A Rolfs,M Ginsberg,Michael G. Hennerici,C Kessler,Edwin H. Kolodny,Peter Martus,B Norrving,Erich Bernd Ringelstein,Peter M. Rothwell,Graham Venables,N. M. Bornstein,P deDeyn,M Dichgans,F Fazekas,Hugh S. Markus,O Rieß,C Biedermann,T Böttcher,K Brüderlein,J Burmeister,I Federow,F König,G Makowei,D Niemann,S Rösner,S Zielke,U Grittner,M Holzhausen,Christian Enzinger,R. Schmidt,Stefan Ropele,M Windisch,E Sterner,Olaf Bodamer,A Fellgiebel,U Hillen,L Jonas,Christoph Kampmann,Peter Kropp,Karl J. Lackner,M Laue,H Mascher,W Meyer,E Paschke,Frank Weidemann,Jörg Berrouschot,Anett Stoll,A Rokicha,C Sternitzky,M Thomä,PP DeDeyn,Rishi Sheorajpanday,I De Brabander,Laetitia Yperzeele,Raf Brouns,P Oschmann,M Pott,K Schultes,C Schultze,J Hirsekorn,GJ Jungehulsing,Arno Villringer,Wolf U. Schmidt,Thomas G. Liman,Tim Nowe,Martin Ebinger,A Wille,H Loui,A Objartel,A übelacker,R Mette,K Jegzentis,Darius G. Nabavi,O Crome,D Bahr,M Ebke,B Platte,C Kleinen,K Mermolja Gunther,Wolfgang Heide,O Pape,JR Hanssen,D Stangenberg,J Klingelhofer,Boris Schmidt,S Schwarz,J Schwarze,L Frandlih,J Iwanow,I Steinbach,Derk W. Krieger,Gudrun Boysen,L Leth Jeppesen,A Petersen,Heinz Reichmann,U Becker,I Dzialkowski,H Hentschel,Christian Lautenschläger,H Hanso,G Gahn,T Ziemssen,K Fleischer,B Sehr,Djh McCabe,O Tobin,J Kinsella,RP Murphy,Sebastian Jander,HP Hartung,Mario Siebler,C Bottcher,A Kohne,J Platzen,TC Brosig,V Rothhammer,C Henseler,Tobias Neumann-Haefelin,Oliver C. Singer,U Ermis,Imrm dos Santos,C Schuhmann,S van de Loo,M. Kaps,Jens Allendörfer,C Tanislav,M Brandtner,Keith W. Muir,Krishna A Dani,N MacDougall,Wade S. Smith,A Rowe,A Welch,G Schrotter,U Krenn,S Horner,B Pendl,A Pluta-Fuerst,U Trummer,M Chatzopoulos,Bettina von Sarnowski,Ulf Schminke,T Link,A Khaw,E Nieber,Stephan Zierz,Thomas Müller,N Wegener,K Wartenberg,C Gaul,D Richter,M Rosenkranz,Anna Krützelmann,Julia Hoppe,Cu Choe,S Narr,TU Magnus,Götz Thomalla,Frank Leypoldt,D Otto,C Lichy,Werner Hacke,RJ Barrows,T Tatlisumak,Jukka Putaala,Sami Curtze,M Metso,J Willeit,M Furtner,M Spiegel,MH Knoflach,B Prantl,Otto W. Witte,Dirk Brämer,Albrecht Günther,Tino Prell,C Herzau,Konstanze Aurich,Günther Deuschl,Fritz Wodarg,Philip Zimmermann,Christoph C. Eschenfelder,M Levsen,JR Weber,SM Marecek,Dietmar Schneider,Dominik Michalski,W Kloppig,L Küppers-Tiedt,M Schneider,A Schulz,P Matzen,C Weise,Carsten Hobohm,H Meier,R Langos,D Urban,I Gerhardt,Vincent Thijs,Robin Lemmens,E Marcelis,C Hulsbosch,F Aichner,Hans-Peter Haring,E Bach,J Machado Candido,AA e Silva,M Lourenco,Aim de Sousa,Laurent Derex,TH Cho,E. Díez-Tejedor,B. Fuentes,Patricia Martínez-Sánchez,MI Pérez-Guevara,H Hamer,A Metz,K Hallenberger,P Müller,Pierluigi Baron,Anna Bersano,M. Gattinoni,N Vella,M Mallia,M. Jauss,L Adam,F Heidler,C Gube,M Kiszka,A Karpinska,Y Mewald,Volker Straub,A Dörr,A Zollver,M Schilling,A Borchert,N Preuth,Thomas Duning,Gregor Kuhlenbäumer,D Schulte,Lars Marquardt,F Schlachetzki,S. Boy,J Mädl,GM Ertl,Npr Fehm,C Stadler,Reiner Benecke,Ales Dudesek,S Kolbaske,G Lardurner,C Sulzer,A Zerbs,S Lilek,AM Walleczek,D Sinadinowska,M Janelidze,Maia Beridze,N Lobjanidze,A Dzagnidze,A Melms,K Horber,I Fink,B Liske,Albert C. Ludolph,Roman Huber,K Knauer,Corinna Hendrich,S Raubold,Anna Członkowska,A Baranowska,B Blazejewska-Hyzorek,W Lang,W Kristoferitsch,Julia Ferrari,E Ulrich,A Flamm-Horak,A Lischka-Lindner,W Schreiber,Vida Demarin,Z Tranjec,M Bosner-Puretic,Miljenka-Jelena Jurašić,V Basic Kes,Mislav Budišić,L Kopacevic +313 more
TL;DR: Silent infarcts, white matter intensities, and classical risk factors were highly prevalent, emphasizing the need for new early preventive strategies.
Journal ArticleDOI
Neurofilament markers for ALS correlate with extent of upper and lower motor neuron disease.
Koen Poesen,Maxim De Schaepdryver,Beatrice Stubendorff,Benjamin Gille,Petra Muckova,Sindy Wendler,Tino Prell,Thomas M. Ringer,Heidrun Rhode,Olivier Stevens,Kristl G. Claeys,Goedele Couwelier,Ann D'Hondt,Nikita Lamaire,Petra Tilkin,Dimphna Van Reijen,Sarah Gourmaud,Nadin Fedtke,Bianka Heiling,Matthias Rumpel,A. Rödiger,A. Gunkel,Otto W. Witte,Claire Paquet,Rik Vandenberghe,Julian Grosskreutz,Philip Van Damme +26 more
TL;DR: This study provides Class II evidence that elevated concentrations of CSF pNfH and NfL can accurately identify patients with ALS and shows an added value as diagnostic biomarkers for ALS, whereas the prognostic value of pNFH andNfL warrants further investigation.
Journal ArticleDOI
The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis.
TL;DR: New research findings on the interaction between endoplasmic reticulum (ER) and mitochondria and its effect on calcium signaling and oxidative stress are reviewed, providing evidence that structures of the ER mitochondria calcium cycle serve as a promising targets for therapeutic approaches for treatment of ALS.
Journal ArticleDOI
Longitudinal diffusion tensor imaging in amyotrophic lateral sclerosis
TL;DR: Diffusion tensor imaging detects changes that are regarded as prominent features of ALS and thus, shows promise in its function as a biomarker.