R
Rick A.A. van der Spek
Researcher at Utrecht University
Publications - 21
Citations - 1680
Rick A.A. van der Spek is an academic researcher from Utrecht University. The author has contributed to research in topics: Project MinE & Amyotrophic lateral sclerosis. The author has an hindex of 13, co-authored 21 publications receiving 1008 citations. Previous affiliations of Rick A.A. van der Spek include University Medical Center Utrecht.
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Journal ArticleDOI
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
Wouter van Rheenen,Aleksey Shatunov,Annelot M. Dekker,Russell L. McLaughlin,Frank P. Diekstra,Sara L. Pulit,Rick A.A. van der Spek,Urmo Võsa,Simone de Jong,Simone de Jong,Matthew R. Robinson,Jian Yang,Isabella Fogh,Isabella Fogh,Perry T.C. van Doormaal,Gijs H.P. Tazelaar,Max Koppers,Anna M. Blokhuis,William Sproviero,Ashley R. Jones,Kevin P. Kenna,Kristel R. van Eijk,Oliver Harschnitz,Raymond D. Schellevis,William J. Brands,Jelena Medic,Androniki Menelaou,Alice Vajda,Alice Vajda,Nicola Ticozzi,Kuang Lin,Boris Rogelj,Katarina Vrabec,Metka Ravnik-Glavač,Blaž Koritnik,Janez Zidar,Lea Leonardis,Leja Dolenc Grošelj,Stéphanie Millecamps,François Salachas,Vincent Meininger,Mamede de Carvalho,Susana Pinto,Jesus S. Mora,Ricardo Rojas-García,Meraida Polak,Siddharthan Chandran,Shuna Colville,Robert Swingler,Karen E. Morrison,Pamela J. Shaw,John Hardy,Richard W. Orrell,Alan M. Pittman,Katie Sidle,Pietro Fratta,Andrea Malaspina,Simon Topp,Susanne Petri,Susanne Abdulla,Carsten Drepper,Michael Sendtner,Thomas F. Meyer,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Kim A. Staats,Martina Wiedau-Pazos,Catherine Lomen-Hoerth,Vivianna M. Van Deerlin,John Q. Trojanowski,Lauren Elman,Leo McCluskey,A. Nazli Basak,Ceren Tunca,Hamid Hamzeiy,Yesim Parman,Thomas Meitinger,Peter Lichtner,Milena Radivojkov-Blagojevic,Christian R. Andres,Cindy Maurel,Gilbert Bensimon,Bernhard Landwehrmeyer,Alexis Brice,Christine Payan,Safaa Saker-Delye,Alexandra Durr,Nicholas W. Wood,Lukas Tittmann,Wolfgang Lieb,Andre Franke,Marcella Rietschel,Sven Cichon,Markus M. Nöthen,Philippe Amouyel,Christophe Tzourio,Jean-François Dartigues,André G. Uitterlinden,Fernando Rivadeneira,Karol Estrada,Albert Hofman,Albert Hofman,Charles Curtis,Charles Curtis,Hylke M. Blauw,Anneke J. van der Kooi,Marianne de Visser,An Goris,Markus Weber,Christopher Shaw,Bradley N. Smith,Orietta Pansarasa,Cristina Cereda,Roberto Del Bo,Giacomo P. Comi,Sandra D'Alfonso,Cinzia Bertolin,Gianni Sorarù,Letizia Mazzini,Viviana Pensato,Cinzia Gellera,Cinzia Tiloca,Antonia Ratti,Andrea Calvo,Cristina Moglia,Maura Brunetti,Simona Arcuti,Rosa Capozzo,Chiara Zecca,Christian Lunetta,Silvana Penco,Nilo Riva,Alessandro Padovani,Massimiliano Filosto,Bernard Muller,Robbert Jan Stuit,Ian P. Blair,Katharine Y. Zhang,Emily P. McCann,Jennifer A. Fifita,Garth A. Nicholson,Garth A. Nicholson,Dominic B. Rowe,Roger Pamphlett,Matthew C. Kiernan,Julian Grosskreutz,Otto W. Witte,Thomas M. Ringer,Tino Prell,Beatrice Stubendorff,Ingo Kurth,Christian A. Hübner,P. Nigel Leigh,Federico Casale,Adriano Chiò,Ettore Beghi,Elisabetta Pupillo,Rosanna Tortelli,Giancarlo Logroscino,John Powell,Albert C. Ludolph,Jochen H. Weishaupt,Wim Robberecht,Philip Van Damme,Lude Franke,Tune H. Pers,Robert H. Brown,Jonathan D. Glass,John Landers,Orla Hardiman,Orla Hardiman,Peter M. Andersen,Peter M. Andersen,Philippe Corcia,Patrick Vourc'h,Vincenzo Silani,Naomi R. Wray,Peter M. Visscher,Paul I.W. de Bakker,Michael A. van Es,R. Jeroen Pasterkamp,Cathryn M. Lewis,Gerome Breen,Gerome Breen,Ammar Al-Chalabi,Leonard H. van den Berg,Jan H. Veldink +187 more
TL;DR: Evidence of ALS being a complex genetic trait with a polygenic architecture is established and the SNP-based heritability is estimated at 8.5%, with a distinct and important role for low-frequency variants (frequency 1–10%).
Journal ArticleDOI
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.
Aude Nicolas,Kevin P. Kenna,Alan E. Renton,Alan E. Renton,Nicola Ticozzi,Faraz Faghri,Faraz Faghri,Ruth Chia,Janice A. Dominov,Brendan J. Kenna,Mike A. Nalls,Pamela Keagle,Alberto M. Rivera,Wouter van Rheenen,Natalie A. Murphy,Joke J.F.A. van Vugt,Joshua T. Geiger,Rick A.A. van der Spek,Hannah A. Pliner,Shankaracharya,Bradley N. Smith,Giuseppe Marangi,Giuseppe Marangi,Simon Topp,Yevgeniya Abramzon,Yevgeniya Abramzon,Athina Soragia Gkazi,John D. Eicher,Aoife Kenna,Francesco Logullo,Isabella Simone,Giancarlo Logroscino,Fabrizio Salvi,Ilaria Bartolomei,Giuseppe Borghero,Maria Rita Murru,Emanuela Costantino,Carla Pani,Roberta Puddu,Carla Caredda,Valeria Piras,Stefania Tranquilli,Stefania Cuccu,Daniela Corongiu,Maurizio Melis,Antonio Milia,Francesco Marrosu,Maria Giovanna Marrosu,Gianluca Floris,Antonino Cannas,Margherita Capasso,Claudia Caponnetto,Gianluigi Mancardi,Paola Origone,Paola Mandich,Francesca Luisa Conforti,Sebastiano Cavallaro,Gabriele Mora,Kalliopi Marinou,Riccardo Sideri,Silvana Penco,Lorena Mosca,Christian Lunetta,Giuseppe Lauria Pinter,Massimo Corbo,Nilo Riva,Paola Carrera,Paolo Volanti,Jessica Mandrioli,Nicola Fini,Antonio Fasano,Lucio Tremolizzo,A Arosio,Carlo Ferrarese,Francesca Trojsi,Gioacchino Tedeschi,Maria Rosaria Monsurrò,Giovanni Piccirillo,Cinzia Femiano,Anna Ticca,Enzo Ortu,Vincenzo La Bella,Rossella Spataro,Tiziana Colletti,Mario Sabatelli,Marcella Zollino,Amelia Conte,Marco Luigetti,Serena Lattante,Marialuisa Santarelli,Antonio Petrucci,Maura Pugliatti,Angelo Pirisi,Leslie D. Parish,Patrizia Occhineri,Fabio Giannini,Stefania Battistini,Claudia Ricci,Michele Benigni,Tea B. Cau,Daniela Loi,Andrea Calvo,Cristina Moglia,Maura Brunetti,Marco Barberis,Gabriella Restagno,Federico Casale,Giuseppe Marrali,Giuseppe Fuda,Irene Ossola,Stefania Cammarosano,Antonio Canosa,Antonio Ilardi,Umberto Manera,Maurizio Grassano,Raffaella Tanel,Fabrizio Pisano,Letizia Mazzini,Sonia Messina,Isabella Laura Simone,Sandra D'Alfonso,Lucia Corrado,Luigi Ferrucci,Matthew B. Harms,David Goldstein,Neil A. Shneider,Stephen A. Goutman,Zachary Simmons,Timothy M. Miller,Siddharthan Chandran,Suvankar Pal,George Manousakis,Stanley H. Appel,Ericka Simpson,Leo H. Wang,Robert H. Baloh,Summer B. Gibson,Richard Bedlack,David Lacomis,Dhruv Sareen,Alexander Sherman,Lucie Bruijn,Michelle Penny,Cristiane de Araújo Martins Moreno,Sitharthan Kamalakaran,Andrew S. Allen,Stanley Appel,Richard S. Bedlack,Braden E. Boone,Robert H. Brown,John P. Carulli,Alessandra Chesi,Wendy K. Chung,Elizabeth T. Cirulli,Gregory M. Cooper,Julien Couthouis,Aaron G. Day-Williams,Patrick A. Dion,Aaron D. Gitler,Jonathan D. Glass,Yujun Han,Timothy D. Harris,Sebastian D. Hayes,Angela Jones,Jonathan Keebler,Brian J. Krueger,Brittany N. Lasseigne,Shawn Levy,Yi-Fan Lu,Tom Maniatis,Diane McKenna-Yasek,Richard M. Myers,Slavé Petrovski,Stefan M. Pulst,Alya R. Raphael,John M. Ravits,Zhong Ren,Guy A. Rouleau,Peter C. Sapp,Katherine B. Sims,John F. Staropoli,Lindsay L. Waite,Quanli Wang,Jack R. Wimbish,Winnie Xin,Hemali Phatnani,Justin Y. Kwan,James R. Broach,Ximena Arcila-Londono,Edward B. Lee,Vivianna M. Van Deerlin,Ernest Fraenkel,Lyle W. Ostrow,Frank Baas,Noah Zaitlen,James D. Berry,Andrea Malaspina,Pietro Fratta,Gregory A. Cox,Leslie M. Thompson,Steve Finkbeiner,Efthimios Dardiotis,Eran Hornstein,Daniel MacGowan,Terry Heiman-Patterson,Molly G. Hammell,Nikolaos A. Patsopoulos,Joshua Dubnau,Avindra Nath,Rajeeva Musunuri,Uday S. Evani,Avinash Abhyankar,Michael C. Zody,Julia A. Kaye,Steven Finkbeiner,Stacia K. Wyman,Alexander LeNail,Leandro Lima,Jeffrey D. Rothstein,Clive N. Svendsen,Jenny Van Eyk,Nicholas J. Maragakis,Stephen J. Kolb,Merit Cudkowicz,Emily G. Baxi,Stacia Wyman,Alex LeNail,Jennifer E. Van Eyk,Michael Benatar,J. Paul Taylor,Gang Wu,Evadnie Rampersaud,Joanne Wuu,Rosa Rademakers,Stephan Züchner,Rebecca Schüle,Jacob L. McCauley,Sumaira Hussain,Anne Cooley,Marielle Wallace,Christine Clayman,Richard J. Barohn,Jeffrey Statland,John Ravits,Andrea Swenson,Carlayne E. Jackson,Jaya Trivedi,Shaida Khan,Jonathan L. Katz,Liberty Jenkins,Ted M. Burns,Kelly G. Gwathmey,James Caress,Corey T. McMillan,Lauren Elman,Erik P. Pioro,Jeannine M. Heckmann,Yuen T. So,David Walk,Samuel Maiser,Jinghui Zhang,Vincenzo Silani,C. Gellera,Antonia Ratti,Franco Taroni,Giuseppe Lauria,Federico Verde,Isabella Fogh,Cinzia Tiloca,Giacomo P. Comi,Gianni Sorarù,Cristina Cereda,Fabiola De Marchi,Stefania Corti,Mauro Ceroni,Gabriele Siciliano,Massimiliano Filosto,Maurizio Inghilleri,Silvia Peverelli,Claudia Colombrita,Barbara Poletti,Luca Maderna,Roberto Del Bo,Stella Gagliardi,Giorgia Querin,Cinzia Bertolin,Viviana Pensato,Barbara Castellotti,William Camu,Kevin Mouzat,Serge Lumbroso,Philippe Corcia,Vincent Meininger,Gérard Besson,Emmeline Lagrange,Pierre Clavelou,Nathalie Guy,Philippe Couratier,Patrick Vourc'h,Veronique Danel,Emilien Bernard,Gwendal Lemasson,Hannu Laaksovirta,Liisa Myllykangas,Lilja Jansson,Miko Valori,John Ealing,Hisham Hamdalla,Sara Rollinson,Stuart Pickering-Brown,Richard W. Orrell,Katie C. L. Sidle,John Hardy,Andrew B. Singleton,Janel O. Johnson,Sampath Arepalli,Meraida Polak,Seneshaw Asress,Safa Al-Sarraj,Andrew T. King,Claire Troakes,Caroline Vance,Jacqueline de Belleroche,Anneloor L.M.A. ten Asbroek,José Luis Muñoz-Blanco,Dena G. Hernandez,Jinhui Ding,J. Raphael Gibbs,Sonja W. Scholz,Mary Kay Floeter,Roy H. Campbell,Francesco Landi,Robert Bowser,Daniel J. L. MacGowan,Janine Kirby,Erik P. Pioro,Roger Pamphlett,James Broach,Glenn S. Gerhard,Travis Dunckley,Christopher B. Brady,Christopher B. Brady,Neil W. Kowall,Juan C. Troncoso,Isabelle Le Ber,Terry Heiman-Patterson,Terry Heiman-Patterson,Freya Kamel,Ludo Van Den Bosch,Tim M. Strom,Thomas Meitinger,Aleksey Shatunov,Kristel R. van Eijk,Mamede de Carvalho,Maarten Kooyman,Bas Middelkoop,Matthieu Moisse,Russell L. McLaughlin,Michael A. van Es,Markus Weber,Kevin B. Boylan,Marka van Blitterswijk,Karen E. Morrison,A. Nazli Basak,Jesus S. Mora,Vivian E. Drory,Pamela J. Shaw,Martin R Turner,Kevin Talbot,Orla Hardiman,Kelly L. Williams,Jennifer A. Fifita,Garth A. Nicholson,Garth A. Nicholson,Ian P. Blair,Jesús Esteban-Pérez,Alberto García-Redondo,Ammar Al-Chalabi,Ahmad Al Kheifat,Peter M. Andersen,Adriano Chiò,Jonathan Cooper-Knock,Annelot M. Dekker,Vivian E. Drory,Alberto Garcia Redondo,Marc Gotkine,Winston Hide,Alfredo Iacoangeli,Jonathan Glass,K.P. Kenna,Matthew C. Kiernan,John E. Landers,Russell McLaughlin,Jonathan Mill,Miguel Mitne Neto,Mattieu Moisse,Jesus S. Mora Pardina,Karen E. Morrison,Stephen Newhouse,Susana Pinto,Sara L. Pulit,Wim Robberecht,Pamela Shaw,Chris Shaw,William Sproviero,Gijs H.P. Tazelaar,Philip Van Damme,Leonard H. van den Berg,Rick van der Spek,Kristel R van Eijk,Michael A van Es,Joke van Vugt,J. H. Veldink,Mayana Zatz,Denis C. Bauer,Natalie A. Twine,Ekaterina Rogaeva,Lorne Zinman,Johnathan Cooper-Knock,Alexis Brice,Stephen A. Goutman,Eva L. Feldman,Summer Gibson,Albert C. Ludolph,Peter M Andersen,Jochen H. Weishaupt,John Q. Trojanowski,Robert H. Brown,Leonard H. van den Berg,Jan H. Veldink,David J. Stone,Pentti J. Tienari,Christopher Shaw,Bryan J. Traynor,Bryan J. Traynor,John Landers +435 more
TL;DR: Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia and Charcot-Marie-Tooth type 2.
Journal ArticleDOI
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.
Mark K Bakker,Rick A.A. van der Spek,Wouter van Rheenen,Sandrine Morel,Sandrine Morel,Romain Bourcier,Isabel C Hostettler,Isabel C Hostettler,Varinder S Alg,Kristel R. van Eijk,Masaru Koido,Masato Akiyama,Chikashi Terao,Koichi Matsuda,Robin G Walters,Robin G Walters,Kuang Lin,Liming Li,Iona Y Millwood,Iona Y Millwood,Zhengming Chen,Zhengming Chen,Guy A. Rouleau,Sirui Zhou,Kristiina Rannikmäe,Cathie Sudlow,Henry Houlden,Leonard H. van den Berg,Christian Dina,Olivier Naggara,Jean-Christophe Gentric,Eimad Shotar,François Eugène,Hubert Desal,Bendik S. Winsvold,Bendik S. Winsvold,Sigrid Børte,Sigrid Børte,Sigrid Børte,Marianne Bakke Johnsen,Marianne Bakke Johnsen,Marianne Bakke Johnsen,Ben Michael Brumpton,Marie Søfteland Sandvei,Cristen J. Willer,Kristian Hveem,John-Anker Zwart,John-Anker Zwart,John-Anker Zwart,W M Monique Verschuren,Christoph M. Friedrich,Sven Hirsch,Sabine Schilling,Jérôme Dauvillier,Olivier Martin,Gregory T. Jones,Matthew J. Bown,Matthew J. Bown,Nerissa U. Ko,Helen Kim,Jonathan R. I. Coleman,Jonathan R. I. Coleman,Gerome Breen,Gerome Breen,Jonathan G. Zaroff,Catharina J.M. Klijn,Rainer Malik,Martin Dichgans,Muralidharan Sargurupremraj,Turgut Tatlisumak,Philippe Amouyel,Stéphanie Debette,Gabriel J.E. Rinkel,Bradford B. Worrall,Joanna Pera,Agnieszka Slowik,Emília Gaál-Paavola,Mika Niemelä,Juha E. Jääskeläinen,Mikael von und zu Fraunberg,Antti E. Lindgren,Joseph P. Broderick,David J. Werring,Daniel Woo,Richard Redon,Philippe Bijlenga,Yoichiro Kamatani,Jan H. Veldink,Ynte M. Ruigrok +88 more
TL;DR: A cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry discovered 17 risk loci, 11 of which are new, which reveal a polygenic architecture and explain over half of the disease heritability.
Posted ContentDOI
Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Wouter van Rheenen,Rick A.A. van der Spek,Mark K Bakker,Joke J.F.A. van Vugt,Paul J. Hop,Ramona A. J. Zwamborn,Niek de Klein,Harm-Jan Westra,Olivier B. Bakker,Patrick Deelen,Patrick Deelen,Gemma Shireby,Eilis Hannon,Matthieu Moisse,Denis Baird,Restuadi Restuadi,Egor Dolzhenko,Annelot M. Dekker,Klara Gawor,Henk-Jan Westeneng,Gijs H.P. Tazelaar,Kristel R. van Eijk,Maarten Kooyman,Ross P. Byrne,Mark A. Doherty,Mark Heverin,Ahmad Al Khleifat,Alfredo Iacoangeli,Alfredo Iacoangeli,Aleksey Shatunov,Nicola Ticozzi,Johnathan Cooper-Knock,Bradley N. Smith,Marta Gromicho,Siddharthan Chandran,Suvankar Pal,Karen E. Morrison,Pamela J. Shaw,John Hardy,Richard W. Orrell,Michael Sendtner,Thomas Meyer,Nazli Basak,Anneke J. van der Kooi,Antonia Ratti,Isabella Fogh,Cinzia Gellera,Giuseppe Lauria Pinter,Stefania Corti,Cristina Cereda,Daisy Sproviero,Sandra D'Alfonso,Gianni Sorarù,Gabriele Siciliano,Massimiliano Filosto,Alessandro Padovani,Adriano Chiò,Andrea Calvo,Cristina Moglia,Maura Brunetti,Antonio Canosa,Maurizio Grassano,Ettore Beghi,Elisabetta Pupillo,Giancarlo Logroscino,Beatrice Nefussy,Alma Osmanovic,Angelica Nordin,Yossef Lerner,Yossef Lerner,Michal Zabari,Michal Zabari,Marc Gotkine,Marc Gotkine,Robert H. Baloh,Shaughn Bell,Patrick Vourc'h,Philippe Corcia,Philippe Couratier,Stéphanie Millecamps,Vincent Meininger,François Salachas,Jesus S. Mora Pardina,Abdelilah Assialioui,Ricardo Rojas-García,Patrick A. Dion,Jay P. Ross,Jay P. Ross,Albert C. Ludolph,Jochen H. Weishaupt,David A. Brenner,Axel Freischmidt,Axel Freischmidt,Gilbert Bensimon,Alexis Brice,Alexandra Durr,Christine Payan,Safa Saker-Delye,Nicholas W. Wood,Simon Topp,Rosa Rademakers,Lukas Tittmann,Wolfgang Lieb,Andre Franke,Stephan Ripke,Stephan Ripke,Stephan Ripke,Alice Braun,Julia Kraft,David C. Whiteman,Catherine M. Olsen,André G. Uitterlinden,Albert Hofman,Marcella Rietschel,Sven Cichon,Markus M. Nöthen,Philippe Amouyel,Bryan J. Traynor,Bryan J. Traynor,Adrew B. Singleton,Miguel Mitne Neto,Ruben J. Cauchi,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Martina Wiedau-Pazos,Catherine Lomen-Hoerth,Vivianna M. Van Deerlin,Julian Grosskreutz,A. Rödiger,Nayana Gaur,Alexander Jörk,Tabea Barthel,Erik Theele,Benjamin Ilse,Beatrice Stubendorff,Otto W. Witte,Robert Steinbach,Christian A. Hübner,Caroline Graff,Lev Brylev,Vera Fominykh,Vera Demeshonok,Anastasia Ataulina,Boris Rogelj,Blaž Koritnik,Janez Zidar,Metka Ravnik-Glavač,Damjan Glavač,Zorica Stevic,Vivian E. Drory,Mònica Povedano,Ian P. Blair,Matthew C. Kiernan,Beben Benyamin,Beben Benyamin,Robert D. Henderson,Robert D. Henderson,Sarah Furlong,Susan Mathers,Pamela A. McCombe,Pamela A. McCombe,Merrilee Needham,Merrilee Needham,Merrilee Needham,Shyuan T. Ngo,Garth A. Nicholson,Roger Pamphlett,Dominic B. Rowe,Frederik J. Steyn,Frederik J. Steyn,Kelly L. Williams,Karen A. Mather,Karen A. Mather,Perminder S. Sachdev,Anjali K. Henders,Leanne Wallace,Mamede de Carvalho,Susana Pinto,Susanne Petri,Markus Weber,Guy A. Rouleau,Vincenzo Silani,Charles Curtis,Gerome Breen,Gerome Breen,Jonathan D. Glass,Robert H. Brown,John Landers,Christopher Shaw,Peter M. Andersen,Ewout J N Groen,Michael A. van Es,R. Jeroen Pasterkamp,Dongsheng Fan,Fleur C. Garton,Allan F. McRae,George Davey Smith,Tom R. Gaunt,Michael A. Eberle,Jonathan Mill,Russell L. McLaughlin,Orla Hardiman,Kevin P. Kenna,Naomi R. Wray,Ellen A. Tsai,Heiko Runz,Lude Franke,Ammar Al-Chalabi,Ammar Al-Chalabi,Philip Van Damme,Leonard H. van den Berg,Jan H. Veldink +212 more
TL;DR: All ALS associated signals combined reveal a role for perturbations in vesicle mediated transport and autophagy, and provide evidence for cell-autonomous disease initiation in glutamatergic neurons.
Journal ArticleDOI
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
Russell L. McLaughlin,Dick Schijven,Wouter van Rheenen,Kristel R. van Eijk,Margaret O'Brien,René S. Kahn,Roel A. Ophoff,Roel A. Ophoff,An Goris,Daniel G. Bradley,Ammar Al-Chalabi,Leonard H. van den Berg,Jurjen J. Luykx,Orla Hardiman,Jan H. Veldink,Aleksey Shatunov,Annelot M. Dekker,Frank P. Diekstra,Sara L. Pulit,Rick A.A. van der Spek,Perry T.C. van Doormaal,William Sproviero,Ashley R. Jones,Garth A. Nicholson,Garth A. Nicholson,Dominic B. Rowe,Roger Pamphlett,Matthew C. Kiernan,Denis C. Bauer,Tim Kahlke,Kelly L. Williams,Filip Eftimov,Isabella Fogh,Nicola Ticozzi,Kuang Lin,Stéphanie Millecamps,François Salachas,Vincent Meininger,Mamede de Carvalho,Susana Pinto,Jesus S. Mora,Ricardo Rojas-García,Meraida Polak,Siddharthan Chandran,Shuna Colville,Robert Swingler,Karen E. Morrison,Karen E. Morrison,Pamela J. Shaw,John Hardy,Richard W. Orrell,Alan M. Pittman,Katie Sidle,Pietro Fratta,Andrea Malaspina,Susanne Petri,Susanna Abdulla,Carsten Drepper,Michael Sendtner,Thomas Meyer,Martina Wiedau-Pazos,Catherine Lomen-Hoerth,Vivianna M. Van Deerlin,John Q. Trojanowski,Lauren Elman,Leo McCluskey,Nazli Basak,Thomas Meitinger,Peter Lichtner,Milena Blagojevic-Radivojkov,Christian R. Andres,Cindy Maurel,Gilbert Bensimon,Bernhard Landwehrmeyer,Alexis Brice,Christine Payan,Safa Saker-Delye,Alexandra Durr,Nicholas W. Wood,Lukas Tittmann,Wolfgang Lieb,Andre Franke,Marcella Rietschel,Sven Cichon,Sven Cichon,Markus M. Nöuthen,Philippe Amouyel,Christophe Tzourio,Jean-François Dartigues,André G. Uitterlinden,Fernando Rivadeneira,Karol Estrada,Albert Hofman,Charles Curtis,Anneke J. van der Kooi,Marianne de Visser,Markus Weber,Christopher Shaw,Bradley N. Smith,Orietta Pansarasa,Cristina Cereda,Roberto Del Bo,Giacomo P. Comi,Sandra D'Alfonso,Cinzia Bertolin,Gianni Sorarù,Letizia Mazzini,Viviana Pensato,Cinzia Gellera,Cinzia Tiloca,Antonia Ratti,Andrea Calvo,Cristina Moglia,Maura Brunetti,Simon Arcuti,Rosa Capozzo,Chiara Zecca,Christian Lunetta,Silvana Penco,Nilo Riva,Alessandro Padovani,Massimiliano Filosto,Ian P. Blair,P. Nigel Leigh,Federico Casale,Adriano Chiò,Ettore Beghi,Elisabetta Pupillo,Rosanna Tortelli,Giancarlo Logroscino,John Powell,Albert C. Ludolph,Jochen H. Weishaupt,Wim Robberecht,Philip Van Damme,Robert H. Brown,Jonathan D. Glass,John Landers,Peter M. Andersen,Peter M. Andersen,Philippe Corcia,Patrick Vourc'h,Vincenzo Silani,Michael A. van Es,R. Jeroen Pasterkamp,Cathryn M. Lewis,Cathryn M. Lewis,Gerome Breen,Gerome Breen,Gerome Breen,Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai-How Farh,Peter Holmans,Phil Lee,Phil Lee,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,David A. Collier,David A. Collier,Hailiang Huang,Hailiang Huang,Tune H. Pers,Tune H. Pers,Tune H. Pers,Ingrid Agartz,Ingrid Agartz,Esben Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberley D. Chambert,Raymond C.K. Chan,Ronald Y. L. Chan,Eric Y.H. Chen,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Ditte Demontis,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Gary Donohoe,Elodie Drapeau,Jubao Duan,Jubao Duan,Frank Dudbridge,Naser Durmishi,Peter Eichhammer,Johan G. Eriksson,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Marion Friedl,Joseph I. Friedman,Menachem Fromer,Menachem Fromer,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Ina Giegling,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jacqueline I. Goldstein,Jacqueline I. Goldstein,Vera Golimbet,Srihari Gopal,Jacob Gratten,Lieuwe de Haan,Christian Hammer,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Stefan Herms,Joel N. Hirschhorn,Joel N. Hirschhorn,Per Hoffmann,Per Hoffmann,A. Hofman,Mads V. Hollegaard,David M. Hougaard,Masashi Ikeda,Inge Joa,Antonio Julià,Luba Kalaydjieva,Sena Karachanak-Yankova,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,James L. Kennedy,Andrey Khrunin,Yunjung Kim,Janis Klovins,James A. Knowles,Bettina Konte,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Hana Kuzelova-Ptackova,Anna K. Kähler,Claudine Laurent,Jimmy Lee,S. Hong Lee,Sophie E. Legge,Bernard Lerer,Miaoxin Li,Tao Li,Kung-Yee Liang,Jeffrey A. Lieberman,Svetlana A. Limborska,Carmel M. Loughland,Jan Lubinski,Jouko Lönnqvist,Milan Macek,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,J. Mallet,Sara Marsal,Manuel Mattheisen,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Derek W. Morris,Ole Mors,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Mari Nelis,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Liene Nikitina-Zake,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,F. Anthony O'Neill,Sang-Yun Oh,Ann Olincy,Line Olsen,Jim van Os,Jim van Os,Christos Pantelis,George N. Papadimitriou,Sergi Papiol,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Tiina Paunio,Milica Pejovic-Milovancevic,Diana O. Perkins,Olli Pietilainen,Jonathan Pimm,Andrew Pocklington,Alkes L. Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Alan R. Sanders,Ulrich Schall,Christian R. Schubert,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Engilbert Sigurdsson,Teimuraz Silagadze,Jeremy M. Silverman,Jeremy M. Silverman,Kang Sim,Petr Slominsky,Jordan W. Smoller,Jordan W. Smoller,Hon-Cheong So,Chris C. A. Spencer,Eli A. Stahl,Eli A. Stahl,Hreinn Stefansson,Stacy Steinberg,Elisabeth Stögmann,Richard E. Straub,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Mythily Subramaniam,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Erik Söderman,Srinivas Thirumalai,Draga Toncheva,Sarah Tosato,Juha Veijola,John L. Waddington,Dermot Walsh,Dai Wang,Qiang Wang,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Emily H. M. Wong,Brandon Wormley,Hualin Simon Xi,Clement C. Zai,Xuebin Zheng,Fritz Zimprich,Naomi R. Wray,Kari Stefansson,Peter M. Visscher,Rolf Adolfsson,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Anders D. Børglum,Ariel Darvasi,Enrico Domenici,Hannelore Ehrenreich,Tõnu Esko,Tõnu Esko,Tõnu Esko,Pablo V. Gejman,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Bryan J. Mowry,Michael John Owen,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +488 more
TL;DR: It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies, and five potential novel ALS-associated loci are identified using conditional false discovery rate analysis.