Janez Zidar

TL;DR: Evidence of ALS being a complex genetic trait with a polygenic architecture is established and the SNP-based heritability is estimated at 8.5%, with a distinct and important role for low-frequency variants (frequency 1–10%).

TL;DR: Recent discoveries have generated new insights into the pathogenesis of a spectrum of disorders called TDP‐43 proteinopathies including: FTLD‐U, FT LD‐U with ALS, ALS, and a broadening spectrum of other disorders.

TL;DR: An unexpected major role for atlastin-1 in the function of sensory neurons is highlighted and HSN I and SPG3A are identified as allelic disorders.

TL;DR: All ALS associated signals combined reveal a role for perturbations in vesicle mediated transport and autophagy, and provide evidence for cell-autonomous disease initiation in glutamatergic neurons.

TL;DR: The identified snoRNAs, mtRNAs and other small RNAs provide possible molecular links between insulin signaling and ALS and indicate muscle tissue is undergoing active reinnervation/compensatory attempts thus providing targets for further research and therapy development in ALS.