R
Raf Van de Plas
Researcher at Delft University of Technology
Publications - 47
Citations - 2005
Raf Van de Plas is an academic researcher from Delft University of Technology. The author has contributed to research in topics: Mass spectrometry imaging & Mass spectrometry. The author has an hindex of 19, co-authored 38 publications receiving 1396 citations. Previous affiliations of Raf Van de Plas include Katholieke Universiteit Leuven & Vanderbilt University.
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Journal ArticleDOI
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
Michael Snyder,Shin Lin,Amanda Posgai,Mark A. Atkinson,Aviv Regev,Jennifer Rood,Orit Rozenblatt-Rosen,Leslie Gaffney,Anna Hupalowska,Rahul Satija,Nils Gehlenborg,Jay Shendure,Julia Laskin,Pehr B. Harbury,Nicholas A. Nystrom,Jonathan C. Silverstein,Ziv Bar-Joseph,Kun Zhang,Katy Börner,Yiing Lin,Richard Conroy,Dena Procaccini,Ananda L. Roy,Ajay Pillai,Marishka Brown,Zorina S. Galis,Caltech-UW Tmc,Long Cai,Cole Trapnell,Dana Jackson,Stanford-WashU Tmc,Garry P. Nolan,William J. Greenleaf,Sylvia K. Plevritis,Sara Ahadi,Stephanie A. Nevins,Hayan Lee,Christian Martijn Schuerch,Sarah Black,Vishal G. Venkataraaman,Ed Esplin,Aaron M. Horning,Amir Bahmani,Ucsd Tmc,Xin bSun,Sanjay Jain,James S. Hagood,Gloria S. Pryhuber,Peter V. Kharchenko,Bernd bBodenmiller,Todd M. Brusko,Michael J. Clare-Salzler,Harry S. Nick,Kevin J. Otto,Clive hWasserfall,Marda Jorgensen,Maigan A. Brusko,Sergio Maffioletti,Richard M. Caprioli,Jeffrey M. Spraggins,Danielle cGutierrez,Nathan Heath Patterson,Elizabeth K. Neumann,Raymond C. Harris,Mark P. deCaestecker,Agnes B. Fogo,Raf Van de Plas,Ken S. Lau,Guo-Cheng Yuan,Qian Zhu,Ruben Dries,Harvard Ttd,Peng Yin,Sinem K. Saka,Jocelyn Y. Kishi,Yu Wang,Isabel Goldaracena,Purdue Ttd,DongHye Ye,Kristin E. Burnum-Johnson,Paul D. Piehowski,Charles Ansong,Ying Zhu,Stanford Ttd,Tushar bDesai,Jay Mulye,Peter Chou,Monica Nagendran,Visualization HuBMAP Integration,Sarah A. Teichmann,Benedict aten,Robert F. dMurphy,Jian Ma,Vladimir Yu. Kiselev,Carl Kingsford,Allyson Ricarte,Maria Keays,Sushma A. Akoju,Matthew Ruffalo,Margaret Vella,Chuck McCallum,Leonard E. Cross,Samuel H. Friedman,Randy Heiland,Bruce Herr,Paul Macklin,Ellen M. Quardokus,Lisel Record,James P. Sluka,Griffin M. Weber,Engagement Component,Philip D. Blood,Alexander J. Ropelewski,William E. Shirey,Robin M. Scibek,Paula M. Mabee,W. Christopher Lenhardt,Kimberly Robasky,Stavros Michailidis,John C. Marioni,Andrew Butler,Tim Stuart,Eyal Fisher,Shila Ghazanfar,Gökcen Eraslan,Tommaso Biancalani,Eeshit Dhaval Vaishnav,Ananda L. Roy,Zorina S. Galis,Pothur Srinivas,Aaron Pawlyk,Salvatore Sechi,Elizabeth L. Wilder,James E. Anderson +133 more
TL;DR: The NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping.
Journal ArticleDOI
A tutorial on support vector machine-based methods for classification problems in chemometrics.
TL;DR: This tutorial provides a concise overview of support vector machines and different closely related techniques for pattern classification, illustrated on three real-life applications in the field of metabolomics, genetics and proteomics.
Journal ArticleDOI
Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping
TL;DR: The potential of image fusion is demonstrated through 'sharpening' of IMS images, which uses microscopy measurements to predict ion distributions at a spatial resolution that exceeds that of measured ion images by ten times or more, and prediction of ion distributions in tissue areas that were not measured by IMS.
Journal ArticleDOI
Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles
Eyra Marien,Michael Meister,Thomas Muley,Steffen Fieuws,Sergio Bordel,Rita Derua,Jeffrey M. Spraggins,Raf Van de Plas,Raf Van de Plas,Jonas Dehairs,Jens Wouters,Muralidhararao Bagadi,Hendrik Dienemann,Michael Thomas,Philipp A. Schnabel,Richard M. Caprioli,Etienne Waelkens,Johannes V. Swinnen +17 more
TL;DR: Using both shotgun and 2D‐imaging lipidomics analysis, a hitherto unrecognized alteration in phospholipid profiles in NSCLC is uncovered, which may have important biological implications and may have significant potential for biomarker development.
Journal ArticleDOI
High-Performance Molecular Imaging with MALDI Trapped Ion-Mobility Time-of-Flight (timsTOF) Mass Spectrometry.
Jeffrey M. Spraggins,Katerina V. Djambazova,Emilio S. Rivera,Lukasz G. Migas,Elizabeth K. Neumann,Arne Fuetterer,Juergen Suetering,Niels Goedecke,Alice Ly,Raf Van de Plas,Raf Van de Plas,Richard M. Caprioli +11 more
TL;DR: It is shown that the MALDI timsTOF platform can maintain reasonable data acquisition rates while providing the specificity necessary to differentiate components in complex mixtures of lipid adducts, and provides a uniquely tunable platform to address many challenges associated with advanced molecular imaging applications.