R
Richard M. Scearce
Researcher at Duke University
Publications - 94
Citations - 7210
Richard M. Scearce is an academic researcher from Duke University. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 44, co-authored 93 publications receiving 6461 citations. Previous affiliations of Richard M. Scearce include Brigham and Women's Hospital & Durham University.
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Journal ArticleDOI
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Hua-Xin Liao,Rebecca M. Lynch,Tongqing Zhou,Feng Gao,Feng Gao,S. Munir Alam,S. Munir Alam,Scott D. Boyd,Andrew Fire,Krishna M. Roskin,Chaim A. Schramm,Zhenhai Zhang,Jiang Zhu,Lawrence Shapiro,Lawrence Shapiro,Nisc Comparative Sequencing Program,James C. Mullikin,Sandrasegaram Gnanakaran,Peter T. Hraber,Kevin Wiehe,Kevin Wiehe,Garnett Kelsoe,Garnett Kelsoe,Guang Yang,Guang Yang,Shi-Mao Xia,Shi-Mao Xia,David C. Montefiori,David C. Montefiori,Robert Parks,Robert Parks,Krissey E. Lloyd,Krissey E. Lloyd,Richard M. Scearce,Richard M. Scearce,Kelly A. Soderberg,Kelly A. Soderberg,Myron S. Cohen,Gift Kamanga,Mark K. Louder,Lillian Tran,Yue Chen,Yue Chen,Fangping Cai,Fangping Cai,Sheri Chen,Sheri Chen,Stephanie Moquin,Xiulian Du,M. Gordon Joyce,Sanjay Srivatsan,Baoshan Zhang,Anqi Zheng,George M. Shaw,Beatrice H. Hahn,Thomas B. Kepler,Bette T. Korber,Peter D. Kwong,John R. Mascola,Barton F. Haynes,Barton F. Haynes +60 more
TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.
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Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies
Barton F. Haynes,Judith A. Fleming,E. William St. Clair,Herman Katinger,Gabriela Stiegler,Renate Kunert,James E. Robinson,Richard M. Scearce,Kelly Plonk,Herman F. Staats,Thomas L. Ortel,Hua-Xin Liao,S. Munir Alam +12 more
TL;DR: It is demonstrated that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin, which may have important implications for generating effective neutralizing antibody responses by using HIV- 1 vaccines.
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Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
Norbert Pardi,Michael J. Hogan,Rebecca S. Pelc,Hiromi Muramatsu,Hanne Andersen,Christina R. DeMaso,Kimberly A. Dowd,Laura L. Sutherland,Richard M. Scearce,Robert Parks,Wendeline Wagner,Alex Granados,Jack Greenhouse,Michelle Walker,Elinor Willis,Jae-Sung Yu,Charles E. McGee,Gregory D. Sempowski,Barbara L. Mui,Ying K. Tam,Yan Jang Huang,Dana L. Vanlandingham,Veronica M. Holmes,Harikrishnan Balachandran,Sujata Sahu,Michelle A. Lifton,Stephen Higgs,Scott E. Hensley,Thomas D. Madden,Michael J. Hope,Katalin Karikó,Sampa Santra,Barney S. Graham,Mark G. Lewis,Theodore C. Pierson,Barton F. Haynes,Drew Weissman +36 more
TL;DR: It is demonstrated that a single low-dose intradermal immunization with nucleoside-modified mRNA–LNP elicits rapid and durable protective immunity and therefore represents a new and promising vaccine candidate for the global fight against ZIKV.
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Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.
Norbert Pardi,Michael J. Hogan,Martin S. Naradikian,Kaela Parkhouse,Derek W. Cain,Letitia D. Jones,M. Anthony Moody,Hans P. Verkerke,Arpita Myles,Elinor Willis,Celia C. LaBranche,David C. Montefiori,Jenna L. Lobby,Kevin O. Saunders,Hua-Xin Liao,Bette T. Korber,Laura L. Sutherland,Richard M. Scearce,Peter T. Hraber,István Tombácz,Hiromi Muramatsu,Houping Ni,Daniel A. Balikov,Charles Q. Li,Barbara L. Mui,Ying K. Tam,Florian Krammer,Katalin Karikó,Patricia Polacino,Laurence C. Eisenlohr,Thomas D. Madden,Michael J. Hope,Mark G. Lewis,Kelly K. Lee,Shiu Lok Hu,Scott E. Hensley,Michael P. Cancro,Barton F. Haynes,Drew Weissman +38 more
TL;DR: A recently developed vaccine platform, nucleoside-modified, purified mRNA encapsulated in lipid nanoparticles (mRNA-LNPs), that induces high levels of Tfh and GC B cells that are associated with long-lived and high-affinity neutralizing antibodies and durable protection.
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The Role of Antibody Polyspecificity and Lipid Reactivity in Binding of Broadly Neutralizing Anti-HIV-1 Envelope Human Monoclonal Antibodies 2F5 and 4E10 to Glycoprotein 41 Membrane Proximal Envelope Epitopes
S. Munir Alam,Mildred W. Mcadams,David Boren,Michael Rak,Richard M. Scearce,Feng Gao,Zenaido T. Camacho,Daniel T. Gewirth,Garnett Kelsoe,P Chen,Barton F. Haynes +10 more
TL;DR: The similarity of 2F5 and 4E10 mAbs to known anti-cardiolipin Abs is compared and the model that mAb 2f5 and4E10 binding to HIV-1 involves both viral lipid membrane and gp41 membrane proximal epitopes is supported.