Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma
Sharon J. Diskin,Mario Capasso,Robert W. Schnepp,Kristina A. Cole,Kristina A. Cole,Edward F. Attiyeh,Edward F. Attiyeh,Cuiping Hou,Maura Diamond,Erica L. Carpenter,Cynthia Winter,Hanna Lee,Jayanti Jagannathan,Valeria Latorre,Valeria Latorre,Achille Iolascon,Hakon Hakonarson,Hakon Hakonarson,Marcella Devoto,John M. Maris +19 more
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TLDR
Data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression.Abstract:
John Maris and colleagues identify common variants at 6q16 associated with neuroblastoma susceptibility. The risk variants are located near the HACE1 and LIN28B genes, both of which show altered expression in advanced neuroblastomas.read more
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Journal ArticleDOI
MicroRNA biogenesis pathways in cancer
Shuibin Lin,Richard I. Gregory +1 more
TL;DR: Global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic, highlighting the importance of miRNA dysregulation in cancer.
Journal ArticleDOI
The genetic landscape of high-risk neuroblastoma
Trevor J. Pugh,Olena Morozova,Edward F. Attiyeh,Edward F. Attiyeh,Shahab Asgharzadeh,Shahab Asgharzadeh,Jun S. Wei,Daniel Auclair,Scott L. Carter,Kristian Cibulskis,Megan Hanna,Megan Hanna,Adam Kiezun,Jaegil Kim,Michael S. Lawrence,Lee Lichenstein,Aaron McKenna,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Alex H. Ramos,Alex H. Ramos,Erica Shefler,Andrey Sivachenko,Carrie Sougnez,Chip Stewart,Adrian Ally,Inanc Birol,Readman Chiu,Richard Corbett,Martin Hirst,Shaun D. Jackman,Baljit Kamoh,Alireza Hadj Khodabakshi,Martin Krzywinski,Allan Lo,Richard A. Moore,Karen Mungall,Jenny Q. Qian,Angela Tam,Nina Thiessen,Yongjun Zhao,Kristina A. Cole,Kristina A. Cole,Maura Diamond,Maura Diamond,Sharon J. Diskin,Sharon J. Diskin,Yael P. Mosse,Yael P. Mosse,Andrew Wood,Andrew Wood,Lingyun Ji,Lingyun Ji,Richard Sposto,Richard Sposto,Thomas C. Badgett,Wendy B. London,Yvonne Moyer,Yvonne Moyer,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Malcolm A. Smith,Jaime M. Guidry Auvil,Daniela S. Gerhard,Michael D. Hogarty,Michael D. Hogarty,Steven J.M. Jones,Eric S. Lander,Stacey Gabriel,Gad Getz,Robert C. Seeger,Robert C. Seeger,Javed Khan,Marco A. Marra,Matthew Meyerson,Matthew Meyerson,John M. Maris +76 more
TL;DR: The authors reported a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and notably few recurrently mutated genes in high-risk neuroblastoma.
The Lin28/let-7 Axis Regulates Glucose Metabolism
Hao Zhu,Ng Shyh-Chang,Ayellet V. Segrè,Ayellet V. Segrè,Gen Shinoda,Samar P. Shah,William S. Einhorn,William S. Einhorn,Ayumu Takeuchi,Jesse M. Engreitz,John P. Hagan,Michael G. Kharas,Michael G. Kharas,Achia Urbach,James E. Thornton,Robinson Triboulet,Richard I. Gregory,David Altshuler,David Altshuler,George Q. Daley +19 more
TL;DR: The Lin28/let-7 pathway is established as a central regulator of mammalian glucose metabolism and enriched for genes containing SNPs associated with type 2 diabetes and control of fasting glucose in human genome-wide association studies.
Journal ArticleDOI
Neuroblastoma: developmental biology, cancer genomics and immunotherapy
TL;DR: The key discoveries in the developmental biology, molecular genetics and immunology of neuroblastoma are discussed, as well as new translational tools for bringing these promising scientific advances into the clinic.
Journal ArticleDOI
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
Robert A. Scott,Laura J. Scott,Reedik Mägi,Letizia Marullo,Kyle J. Gaulton,Kyle J. Gaulton,Marika Kaakinen,Natalia Pervjakova,Tune H. Pers,Andrew D. Johnson,John D. Eicher,Anne U. Jackson,Teresa Ferreira,Yeji Lee,Clement Ma,Valgerdur Steinthorsdottir,Gudmar Thorleifsson,Lu Qi,Lu Qi,Natalie R. van Zuydam,Natalie R. van Zuydam,Anubha Mahajan,Han Chen,Peter Almgren,B F Voight,Harald Grallert,Martina Müller-Nurasyid,Janina S. Ried,Nigel W. Rayner,Nigel W. Rayner,Nigel W. Rayner,Neil Robertson,Neil Robertson,Lennart C. Karssen,Elisabeth M. van Leeuwen,Sara M. Willems,Sara M. Willems,Christian Fuchsberger,Phoenix Kwan,Tanya M. Teslovich,Pritam Chanda,Man Li,Yingchang Lu,Christian Dina,Dorothée Thuillier,Loic Yengo,Longda Jiang,Thomas Sparsø,Hans A. Kestler,Hans A. Kestler,Himanshu Chheda,Lewin Eisele,Stefan Gustafsson,Mattias Frånberg,Mattias Frånberg,Mattias Frånberg,Rona J. Strawbridge,Rafn Benediktsson,Astradur B. Hreidarsson,Augustine Kong,Gunnar Sigurðsson,Nicola D. Kerrison,Jian'an Luan,Liming Liang,Thomas Meitinger,Michael Roden,Barbara Thorand,Tõnu Esko,Tõnu Esko,Tõnu Esko,Evelin Mihailov,Caroline S. Fox,Ching-Ti Liu,Denis Rybin,Bo Isomaa,Valeriya Lyssenko,Tiinamaija Tuomi,David Couper,James S. Pankow,Niels Grarup,Christian Theil Have,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,Allan Linneberg,Allan Linneberg,Marilyn C. Cornelis,Rob M. van Dam,Rob M. van Dam,David J. Hunter,Peter Kraft,Qi Sun,Qi Sun,Sarah Edkins,Katharine R. Owen,Katharine R. Owen,John R. B. Perry,Andrew R. Wood,Eleftheria Zeggini,Juan Tajes-Fernandes,Gonçalo R. Abecasis,Lori L. Bonnycastle,Peter S. Chines,Heather M. Stringham,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Leena Kinnunen,Leena Kinnunen,Leena Kinnunen,Bengt Sennblad,Bengt Sennblad,Thomas W. Mühleisen,Markus M. Nöthen,Sonali Pechlivanis,Damiano Baldassarre,Karl Gertow,Steve E. Humphries,Elena Tremoli,Norman Klopp,Julia Meyer,Gerald Steinbach,Roman Wennauer,Johan G. Eriksson,Satu Mӓnnistö,Leena Peltonen,Emmi Tikkanen,Guillaume Charpentier,E. Eury,Stéphane Lobbens,Bruna Gigante,Karin Leander,Olga McLeod,Erwin P. Bottinger,Omri Gottesman,Douglas M. Ruderfer,Matthias Blüher,Peter Kovacs,Anke Tönjes,Nisa M. Maruthur,Chiara Scapoli,Raimund Erbel,Karl-Heinz Jöckel,Susanne Moebus,Ulf de Faire,Anders Hamsten,Michael Stumvoll,Panagiotis Deloukas,Panagiotis Deloukas,Peter Donnelly,Peter Donnelly,Timothy M. Frayling,Andrew T. Hattersley,Samuli Ripatti,Veikko Salomaa,Nancy L. Pedersen,Bernhard O. Boehm,Richard N. Bergman,Francis S. Collins,Karen L. Mohlke,Jaakko Tuomilehto,Torben Hansen,Torben Hansen,Oluf Pedersen,Inês Barroso,Inês Barroso,Lars Lannfelt,Erik Ingelsson,Erik Ingelsson,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Stéphane Cauchi,Philippe Froguel,Philippe Froguel,Ruth J. F. Loos,Beverley Balkau,Beverley Balkau,Heiner Boeing,Paul W. Franks,Paul W. Franks,Aurelio Barricarte Gurrea,Domenico Palli,Yvonne T. van der Schouw,David Altshuler,Leif Groop,Leif Groop,Claudia Langenberg,Nicholas J. Wareham,Eric J.G. Sijbrands,Cornelia M. van Duijn,Jose C. Florez,Jose C. Florez,James B. Meigs,James B. Meigs,Eric Boerwinkle,Eric Boerwinkle,Christian Gieger,Konstantin Strauch,Andres Metspalu,Andrew D. Morris,Colin N. A. Palmer,Frank B. Hu,Frank B. Hu,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Josée Dupuis,Andrew P. Morris,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Inga Prokopenko,Inga Prokopenko,Inga Prokopenko +216 more
TL;DR: This article conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel.
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