A
Andrea Guennoun
Researcher at Qatar Airways
Publications - 7
Citations - 404
Andrea Guennoun is an academic researcher from Qatar Airways. The author has contributed to research in topics: Internal medicine & REL. The author has an hindex of 4, co-authored 6 publications receiving 129 citations.
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Journal ArticleDOI
Human genetic and immunological determinants of critical COVID-19 pneumonia
Qian Zhang,Paul Bastard,Adem Karbuz,A Gervais,Ahmad N. Abou Tayoun,Alessandro Aiuti,Alexandre Belot,Alexandre Bolze,Alexandre Gaudet,Anastasiia Bondarenko,Zhiyong Liu,András N Spaan,Andrea Guennoun,Andrés Augusto Arias,A. Planas,Anna Sediva,Anna Shcherbina,Anna-Lena Neehus,Anne Puel,Antoine Froidure,Antonio Novelli,Aslınur Özkaya Parlakay,Aurora Pujol,Aysun Yahşi,Belgin Gülhan,Benedetta Bigio,Bertrand Boisson,Beth A. Drolet,Carlos Andrés Arango Franco,Carlos Flores,Carlos Rodríguez-Gallego,Carolina Prando,Catherine M. Biggs,Charles-Edouard Luyt,Clifton L. Dalgard,Cliona O'Farrelly,Daniela Matuozzo,David Dalmau,David S. Perlin,Davood Mansouri,Diederik van de Beek,Donald C. Vinh,Elena Domínguez-Garrido,Elena W Y Hsieh,Emine Hafize Erdeniz,Emmanuelle Jouanguy,Esra Şevketoğlu,Estelle Talouarn,Eugenia Quiros-Roldan,Evangelos Andreakos,Eystein S. Husebye,Fahad Alsohime,Filomeen Haerynck,Giorgio Casari,G. Novelli,Gokhan Aytekın,Guillaume Morelle,Gülsüm Alkan,Gülsüm İclal Bayhan,Hagit Baris Feldman,Helen C. Su,Horst von Bernuth,Igor Resnick,Ingrid G Bustos,Isabelle Meyts,Isabelle Migeotte,Ivan Tancevski,Jacinta Bustamante,Jacques Fellay,Jamila El Baghdadi,Javier Martinez-Picado,Jérémie Rosain,Jeremy Manry,Jie Chen,John Christodoulou,J. B. Bohlen,José Luis Franco,Juan Li,Juan-Manuel Anaya,Julian Castaño Rojas,Junqiang Ye,K. M. Furkan Uddin,Kadriye Kart Yaşar,Kai Kisand,Keisuke Okamoto,Khalil Chaïbi,K. Mironska,László Maródi,Laurent Abel,Laurent Rénia,Lazaro Lorenzo,Lennart Hammarström,Lisa F. P. Ng,Lluis Quintana-Murci,Lucía Victoria Erazo,Luigi D. Notarangelo,Luis F. Reyes,Luis M. Allende,Luisa Imberti,Majistor Raj Luxman Maglorius Renkilaraj,Marcela Moncada-Vélez,Marie Materna,Mark E. Anderson,Marta Gut,Marwa Chbihi,Masato Ogishi,Melike Emiroglu,Mikko Seppänen,Mohammed Jasim Uddin,Mohammed Shahrooei,Natalie Carter Alexander,Nevin Hatipoğlu,Nico Marr,Nihal Akçay,Oksana Boyarchuk,Ondrej Slaby,O Akcan,Peng Zhang,Pere Soler-Palacín,Peter K. Gregersen,Petter Brodin,Pierre Garçon,Pierre-Emmanuel Morange,Qiang Pan-Hammarström,Qinhua Zhou,Quentin Philippot,Rabih Halwani,Rebeca Pérez de Diego,Romain Lévy,Rui-Fu Yang,Şadiye Kübra Tüter Öz,Saleh Al Muhsen,Saliha Kanık-Yüksek,Sara Elva Espinosa-Padilla,Sathishkumar Ramaswamy,Satoshi Okada,Sefika Elmas Bozdemir,Selma Erol Aytekin,Şemsi Nur Karabela,Sevgi Keles,Sevtap Şenoğlu,Shen-ying Zhang,Sotirija Duvlis,Stefan N. Constantinescu,Stéphanie Boisson-Dupuis,Stuart E. Turvey,Stuart G. Tangye,Takaki Asano,Tayfun Ozcelik,Tom Le Voyer,Tom Maniatis,Tomohiro Morio,Trine H. Mogensen,Vanessa Sancho-Shimizu,Vivien Béziat,Xavier Solanich,Yenan T. Bryceson,Y.L. Lau,Yuval Itan,Aurélie Cobat,Jean-Laurent Casanova +160 more
TL;DR: In this article , the molecular and cellular determinants of critical COVID-19 pneumonia were reviewed and the TLR3- and TLR7-dependent production of type I interferons by respiratory epithelial cells and plasmacytoid dendritic cells, respectively, is essential for host defence against SARS-CoV-2 infection.
Journal ArticleDOI
Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant
Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Noé Ramírez-Alejo,Zhi Li,Zhi Li,Etienne Patin,Etienne Patin,Geetha Rao,Gaspard Kerner,Gaspard Kerner,Che Kang Lim,Che Kang Lim,Dimitry N. Krementsov,Nicholas Hernandez,Cindy S. Ma,Cindy S. Ma,Qian Zhang,Qian Zhang,Janet Markle,Rubén Martínez-Barricarte,Kathryn Payne,Robert Fisch,Caroline Deswarte,Caroline Deswarte,Joshua Halpern,Matthieu Bouaziz,Matthieu Bouaziz,Jeanette Mulwa,Durga Sivanesan,Durga Sivanesan,Tomi Lazarov,Rodrigo Naves,Patricia García,Yuval Itan,Yuval Itan,Bertrand Boisson,Bertrand Boisson,Bertrand Boisson,Alix Checchi,Alix Checchi,Fabienne Jabot-Hanin,Fabienne Jabot-Hanin,Aurélie Cobat,Aurélie Cobat,Andrea Guennoun,Carolyn C. Jackson,Carolyn C. Jackson,Sevgi Pekcan,Zafer Caliskaner,Jaime Inostroza,Beatriz Tavares Costa-Carvalho,Jose Antonio Tavares de Albuquerque,Humberto García-Ortiz,Lorena Orozco,Tayfun Ozcelik,Ahmed Abid,Ismail Abderahmani Rhorfi,Hicham Souhi,Hicham Naji Amrani,Adil Zegmout,Frederic Geissmann,Stephen W. Michnick,Ingrid Müller-Fleckenstein,Bernhard Fleckenstein,Anne Puel,Anne Puel,Anne Puel,Michael J. Ciancanelli,Nico Marr,Hassan Abolhassani,Hassan Abolhassani,María Elvira Balcells,Antonio Condino-Neto,Alexis Strickler,Katia Abarca,Cory Teuscher,Hans D. Ochs,Ismail Reisli,Esra Hazar Sayar,Jamila El-Baghdadi,Jacinta Bustamante,Lennart Hammarström,Lennart Hammarström,Lennart Hammarström,Stuart G. Tangye,Stuart G. Tangye,Sandra Pellegrini,Sandra Pellegrini,Lluis Quintana-Murci,Lluis Quintana-Murci,Laurent Abel,Laurent Abel,Laurent Abel,Jean-Laurent Casanova +94 more
TL;DR: Homozygosity for the catalytically inactive P1104A missense variant of the TYK2 Janus kinase selectively disrupts the induction of IFN-γ by IL-23 and is a common monogenic etiology of tuberculosis.
Journal ArticleDOI
Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy
Vivien Béziat,Vivien Béziat,Franck Rapaport,Jiafen Hu,Matthias Titeux,Mathilde Bonnet des Claustres,Mathieu Bourgey,Heather Griffin,Élise Bandet,Cindy S. Ma,Cindy S. Ma,Roya Sherkat,Hassan Rokni-Zadeh,David M. Louis,Majid Changi-Ashtiani,Ottavia M. Delmonte,Toshiaki Fukushima,Tanwir Habib,Andrea Guennoun,Taushif Khan,Noemi Bender,Mahbuba Rahman,Frédégonde About,Rui Yang,Geetha Rao,Geetha Rao,Claire Rouzaud,Jingwei Li,Debra A. Shearer,Karla K. Balogh,Fatima Al Ali,Manar Ata,Soroosh Dabiri,Mana Momenilandi,Justine Nammour,Marie Alexandra Alyanakian,Marianne Leruez-Ville,David Guenat,Marie Materna,Léa Marcot,Natasha Vladikine,Christine Soret,Hassan Vahidnezhad,Leila Youssefian,Amir Hossein Saeidian,Jouni Uitto,Emilie Catherinot,Shadi Sadat Navabi,Mohammed Zarhrate,David T. Woodley,Mohamed Jeljeli,Thomas Abraham,Serkan Belkaya,Lazaro Lorenzo,Jérémie Rosain,Mousa Bayat,Fanny Lanternier,Olivier Lortholary,Faramarz Zakavi,Philippe Gros,Gérard Orth,Laurent Abel,Laurent Abel,Jean Luc Prétet,Sylvie Fraitag,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Mark M. Davis,Stuart G. Tangye,Stuart G. Tangye,Luigi D. Notarangelo,Nico Marr,Tim Waterboer,David Langlais,John Doorbar,Alain Hovnanian,Neil D. Christensen,Xavier Bossuyt,Mohammad Shahrooei,Jean-Laurent Casanova,Jean-Laurent Casanova +80 more
TL;DR: In this paper, a patient with the human papilloma virus (HPV)-2-driven "treeman" phenotype and two relatives with unusually severe HPV4-driven warts were found to be unexpectedly homozygous for a private CD28 variant.
Journal ArticleDOI
Chronic mucocutaneous candidiasis and connective tissue disorder in humans with impaired JNK1-dependent responses to IL-17A/F and TGF-β
Juan Li,Marco Ritelli,Cindy S. Ma,Cindy S. Ma,Geetha Rao,Tanwir Habib,Emilie Corvilain,Emilie Corvilain,Salim Bougarn,Sophie Cypowyj,Lucie Grodecká,Romain Lévy,Romain Lévy,Vivien Béziat,Vivien Béziat,Lei Shang,Kathryn Payne,Danielle T. Avery,Mélanie Migaud,Mélanie Migaud,Soraya Boucherit,Soraya Boucherit,Sabri Boughorbel,Andrea Guennoun,Maya Chrabieh,Maya Chrabieh,Franck Rapaport,Benedetta Bigio,Yuval Itan,Yuval Itan,Bertrand Boisson,Bertrand Boisson,Bertrand Boisson,Valérie Cormier-Daire,Valérie Cormier-Daire,Delfien Syx,Fransiska Malfait,Nicoletta Zoppi,Laurent Abel,Laurent Abel,Laurent Abel,Tomáš Freiberger,Harry C. Dietz,Harry C. Dietz,Nico Marr,Nico Marr,Stuart G. Tangye,Stuart G. Tangye,Marina Colombi,Jean-Laurent Casanova,Anne Puel,Anne Puel,Anne Puel +52 more
TL;DR: It is indicated that the integrity of the human JNK1-dependent MAPK signaling pathway is essential for IL-17A– and IL- 17F–dependent mucocutaneous immunity to Candida and for the TGF-β–dependent homeostasis of connective tissues.
Journal ArticleDOI
Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents
Romain Lévy,David Langlais,Vivien Béziat,Vivien Béziat,Franck Rapaport,Geetha Rao,Tomi Lazarov,Mathieu Bourgey,Yu Jerry Zhou,Coralie Briand,Kunihiko Moriya,Fatima Ailal,Danielle T. Avery,Janet Markle,Ai Ing Lim,Masato Ogishi,Rui Yang,Simon J. Pelham,Mehdi Emam,Mélanie Migaud,Caroline Deswarte,Tanwir Habib,Luis R. Saraiva,Eman Abou Moussa,Andrea Guennoun,Bertrand Boisson,Bertrand Boisson,Serkan Belkaya,Rubén Martínez-Barricarte,Jérémie Rosain,Aziz Belkadi,Sylvain Breton,Kathryn Payne,Ibtihal Benhsaien,Alessandro Plebani,Vassilios Lougaris,James P. Di Santo,Bénédicte Neven,Laurent Abel,Laurent Abel,Cindy S. Ma,Ahmed Aziz Bousfiha,Nico Marr,Jacinta Bustamante,Jacinta Bustamante,Kang Liu,Philippe Gros,Frederic Geissmann,Stuart G. Tangye,Jean-Laurent Casanova,Anne Puel,Anne Puel +51 more
TL;DR: In this paper, a child with severe viral, bacterial, fungal, and parasitic diseases was homozygous for a loss-of-function mutation of REL, encoding c-Rel, which is selectively expressed in lymphoid and myeloid cells.