S
Satoru Takahashi
Researcher at University of Tsukuba
Publications - 633
Citations - 31434
Satoru Takahashi is an academic researcher from University of Tsukuba. The author has contributed to research in topics: MAFB & Medicine. The author has an hindex of 79, co-authored 589 publications receiving 28007 citations. Previous affiliations of Satoru Takahashi include Hokkaido University & Nihon University.
Papers
More filters
Journal ArticleDOI
An nrf2/small maf heterodimer mediates the induction of phase ii detoxifying enzyme genes through antioxidant response elements
Ken Itoh,Tomoki Chiba,Satoru Takahashi,Tetsuro Ishii,Kazuhiko Igarashi,Yasutake Katoh,Tatsuya Oyake,Norio Hayashi,Kimihiko Satoh,Ichiro Hatayama,Masayuki Yamamoto,Yo-ichi Nabeshima +11 more
TL;DR: It is demonstrated that Nrf2 is essential for the transcriptional induction of phase II enzymes and the presence of a coordinate transcriptional regulatory mechanism for phase II enzyme genes and the nrf2-deficient mice may prove to be a very useful model for the in vivo analysis of chemical carcinogenesis and resistance to anti-cancer drugs.
Journal ArticleDOI
Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages
Tetsuro Ishii,Ken Itoh,Satoru Takahashi,Hideyo Sato,Toru Yanagawa,Yasutake Katoh,Shiro Bannai,Masayuki Yamamoto +7 more
TL;DR: It is shown that Nrf2 controls the expression of a group of electrophile- and oxidative stress-inducible proteins and activities, which includes heme oxygenase-1, A170, peroxiredoxin MSP23, and cystine membrane transport (system xc −) activity.
Journal ArticleDOI
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
Nobunao Wakabayashi,Ken Itoh,Junko Wakabayashi,Hozumi Motohashi,Shuhei Noda,Satoru Takahashi,Sumihisa Imakado,Tomoe Kotsuji,Fujio Otsuka,Dennis R. Roop,Takanori Harada,James Douglas Engel,Masayuki Yamamoto +12 more
TL;DR: These experiments show that Keap1 acts upstream of Nrf2 in the cellular response to oxidative and xenobiotic stress, and breeding to NRF2-deficient mice reversed the phenotypic Keap 1 deficiencies.
Journal ArticleDOI
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene
Jiying Sun,Jiying Sun,Hideto Hoshino,Hideto Hoshino,Kazuaki Takaku,Osamu Nakajima,Akihiko Muto,Hiroshi Suzuki,Satoshi Tashiro,Satoru Takahashi,Shigeki Shibahara,Jawed Alam,Makoto Mark Taketo,Masayuki Yamamoto,Kazuhiko Igarashi +14 more
TL;DR: regulation of ho‐1 involves a direct sensing of heme levels by Bach1 (by analogy to lac repressor sensitivity to lactose), generating a simple feedback loop whereby the substrate effects repressor–activator antagonism.
Journal ArticleDOI
Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
Keisuke Kataoka,Yuichi Shiraishi,Yohei Takeda,Seiji Sakata,Misako Matsumoto,Seiji Nagano,Takuya Maeda,Yasunobu Nagata,Akira Kitanaka,Seiya Mizuno,Hiroko Tanaka,Kenichi Chiba,Satoshi Ito,Yosaku Watatani,Nobuyuki Kakiuchi,Hiromichi Suzuki,Tetsuichi Yoshizato,Kenichi Yoshida,Masashi Sanada,Hidehiro Itonaga,Yoshitaka Imaizumi,Yasushi Totoki,Wataru Munakata,Hiromi Nakamura,Natsuko Hama,Kotaro Shide,Yoko Kubuki,Tomonori Hidaka,Takuro Kameda,Kyoko Masuda,Nagahiro Minato,Koichi Kashiwase,Koji Izutsu,Akifumi Takaori-Kondo,Yasushi Miyazaki,Satoru Takahashi,Tatsuhiro Shibata,Hiroshi Kawamoto,Yoshiki Akatsuka,Kazuya Shimoda,Kengo Takeuchi,Tsukasa Seya,Satoru Miyano,Seishi Ogawa +43 more
TL;DR: A unique genetic mechanism of immune escape caused by structural variations (SVs) commonly disrupting the 3' region of the PD-L1 gene is shown, supporting the role of relevant SVs in clonal selection through immune evasion and suggesting that PD-l1 3'-UTR disruption could serve as a genetic marker to identify cancers that actively evade anti-tumour immunity through PD- L1 overexpression.