H
Hye Soon Lee
Researcher at Hanyang University
Publications - 76
Citations - 5932
Hye Soon Lee is an academic researcher from Hanyang University. The author has contributed to research in topics: Single-nucleotide polymorphism & Rheumatoid arthritis. The author has an hindex of 25, co-authored 68 publications receiving 5001 citations. Previous affiliations of Hye Soon Lee include North Shore-LIJ Health System & Brigham and Women's Hospital.
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Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus
Elaine F. Remmers,Robert M. Plenge,Annette Lee,Robert R. Graham,Robert R. Graham,Geoffrey Hom,Timothy W. Behrens,Paul I.W. de Bakker,Julie M. Le,Hye Soon Lee,Hye Soon Lee,Franak Batliwalla,Wentian Li,Seth L. Masters,Matthew G. Booty,John P. Carulli,Leonid Padyukov,Lars Alfredsson,Lars Klareskog,Wei V. Chen,Christopher I. Amos,Lindsey A. Criswell,Michael F. Seldin,Daniel L. Kastner,Peter K. Gregersen +24 more
TL;DR: A haplotype of STAT4 is associated with increased risk for both rheumatoid arthritis and systemic lupus erythematosus, suggesting a shared pathway for these illnesses.
Journal ArticleDOI
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
Soumya Raychaudhuri,Cynthia Sandor,Eli A. Stahl,Eli A. Stahl,Jan Freudenberg,Hye Soon Lee,Xiaoming Jia,Xiaoming Jia,Lars Alfredsson,Leonid Padyukov,Lars Klareskog,Jane Worthington,Katherine A. Siminovitch,Sang Cheol Bae,Robert M. Plenge,Robert M. Plenge,Peter K. Gregersen,Paul I.W. de Bakker +17 more
TL;DR: Imputation of functional variation from large reference panels can help fine map association signals in the MHC, and three amino acid positions in HLA-DRβ1, which are all located in peptide-binding grooves, almost completely explain the M HC association to rheumatoid arthritis risk.
Journal ArticleDOI
High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
Celi Sun,Julio E. Molineros,Loren L. Looger,Xu-jie Zhou,Kwangwoo Kim,Yukinori Okada,Jianyang Ma,Yuan-yuan Qi,Xana Kim-Howard,Prasenjeet Motghare,Krishna Bhattarai,Adam Adler,So Young Bang,Hye Soon Lee,Tae-Hwan Kim,Young Mo Kang,Chang Hee Suh,Won Tae Chung,Yong Beom Park,Jung Yoon Choe,Seung Cheol Shim,Yuta Kochi,Akari Suzuki,Michiaki Kubo,Takayuki Sumida,Kazuhiko Yamamoto,Shin-Seok Lee,Young-Jin Kim,Bok Ghee Han,Mikhail G. Dozmorov,Kenneth M. Kaufman,Jonathan D. Wren,John B. Harley,Nan Shen,Nan Shen,Kek Heng Chua,Hong Zhang,Sang Cheol Bae,Swapan K. Nath +38 more
TL;DR: Ten new SLE susceptibility loci are identified and the new loci share functional and ontological characteristics with previously reported loci and are possible drug targets for SLE therapeutics.
Journal ArticleDOI
Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations
Yukinori Okada,Kwangwoo Kim,Buhm Han,Buhm Han,Nisha Esakimuthu Pillai,Rick Twee-Hee Ong,Woei-Yuh Saw,Ma Luo,Ma Luo,Lei Jiang,Jian Yin,So Young Bang,Hye Soon Lee,Matthew A. Brown,Sang Cheol Bae,Huji Xu,Yik Ying Teo,Paul I.W. de Bakker,Soumya Raychaudhuri +18 more
TL;DR: In this article, the authors applied imputation to determine genotypes for eight class I and II HLA genes to Asian populations for the first time using a newly constructed pan-Asian reference panel.