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Stephen R. Quake
Researcher at Stanford University
Publications - 626
Citations - 89247
Stephen R. Quake is an academic researcher from Stanford University. The author has contributed to research in topics: Transcriptome & Biology. The author has an hindex of 132, co-authored 589 publications receiving 77778 citations. Previous affiliations of Stephen R. Quake include Agency for Science, Technology and Research & Allegheny Health Network.
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Viral Taxonomy Derived From Evolutionary Genome Relationships
Tyler J. Dougan,Stephen R. Quake +1 more
TL;DR: A principled model which depends only on the genome sequence is described, which captures many interesting relationships between viral families, and which creates clusters which correlate well with both the Baltimore and ICTV classifications.
Posted ContentDOI
Hepatitis C Virus Infects and Perturbs Liver Stem Cells
Nathan L. Meyers,Tal Ashuach,Danielle E Lyons,Camille R. Simoneau,Ann L Erickson,Mehdi Bouhaddou,Thong T. Nguyen,Mir M. Khalid,Taha Y. Taha,Vaishaali Natarajan,Jody L. Baron,Norma Neff,Fabio Zanini,Tokameh Mahmoud,Stephen R. Quake,Nevan J. Krogan,Stewart Cooper,Todd C. McDevitt,Nir Yosef,Nir Yosef,Melanie Ott +20 more
TL;DR: In this article, the authors identify bipotent liver stem cells as novel targets for hepatitis C virus infection and their erroneous differentiation as the potential cause of impaired liver regeneration and cancer development.
Proceedings ArticleDOI
Abstract 2128: TACH101, a first-in-class pan inhibitor of KDM4 histone lysine demethylases
Sanghee Yoo,Chandtip Chandhasin,Joselyn R. Del Rosario,Young K. Chen,Jeffrey A. Stafford,Stephen R. Quake,Frank Perabo,Michael F. Clarke +7 more
TL;DR: Yoo et al. as mentioned in this paper proposed TACH101, a pan inhibitor of KDM4 histone lysine demethylases, which is shown to be a reversible, α-ketoglutarate competitive, selective and potent inhibitor with IC50 values less than 0.100 μM for all four isoforms.
Proceedings ArticleDOI
Fluorescence apertureless near-field microscope: a step toward imaging information in DNA
TL;DR: The fluorescence apertureless near field microscope (FAWNFIM) as discussed by the authors has been proposed to image information in DNA in order to measure sequence information, but it cannot resolve molecules that are separated by a distance greater than the diffraction limit of the microscope, about 220 nanometers.