S
Stephen R. Quake
Researcher at Stanford University
Publications - 626
Citations - 89247
Stephen R. Quake is an academic researcher from Stanford University. The author has contributed to research in topics: Transcriptome & Biology. The author has an hindex of 132, co-authored 589 publications receiving 77778 citations. Previous affiliations of Stephen R. Quake include Agency for Science, Technology and Research & Allegheny Health Network.
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Patent
Direct molecular diagnosis of fetal aneuploidy
TL;DR: In this article, methods and materials for detection of aneuploidy and other chromosomal abnormalities using fetal tissue are disclosed, using digital PCR for amplification and detection of single target sequences allowing an accurate count of a specific chromosome or chromosomal region.
Patent
Non-invasive diagnosis of graft rejection in organ transplant patients
TL;DR: In this article, the authors provide methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant, which includes determining the presence or absence of one or more nucleic acids from a donor transplant.
Journal ArticleDOI
High-dimensional immune profiling of total and rotavirus VP6-specific intestinal and circulating B cells by mass cytometry
Nitya Nair,Evan W. Newell,Evan W. Newell,Christopher Vollmers,Stephen R. Quake,John M. Morton,Mark M. Davis,Mark M. Davis,Xiao-Song He,Harry B. Greenberg +9 more
TL;DR: The heterogeneity of the intestinal B cell compartment is described, dominated by ASCs with some phenotypic and transcriptional characteristics of long-lived plasma cells, and VP6-specific B cells were present among diverse B cell subsets in immune donors, including naïve B cells, with phenotypes representative of the overall B cell pool.
Journal ArticleDOI
Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting.
Hongjie Li,Tongchao Li,Felix Horns,Jiefu Li,Qijing Xie,Qijing Xie,Chuanyun Xu,Bing Wu,Justus M. Kebschull,Colleen N. McLaughlin,Sai Saroja Kolluru,Robert C. Jones,David Vacek,Anthony Xie,David J. Luginbuhl,Stephen R. Quake,Liqun Luo +16 more
TL;DR: Using single-cell RNA sequencing, it is shown that transcriptomic clusters correspond well with anatomically and physiologically defined ORN types, and one broadly expressed transcription factor only regulates olfactory receptor expression in one ORN type and only wiring specificity in another type.
Journal ArticleDOI
Heterogeneous T cell motility behaviors emerge from a coupling between speed and turning in vivo
TL;DR: Light sheet microscopy of T cells in the larval zebrafish is used as a model system to study motility across large populations of cells over hours in their native context, showing substantial cell-to-cell variability in speed, which persists over timespans of a few hours.