S
Stephen R. Quake
Researcher at Stanford University
Publications - 626
Citations - 89247
Stephen R. Quake is an academic researcher from Stanford University. The author has contributed to research in topics: Transcriptome & Biology. The author has an hindex of 132, co-authored 589 publications receiving 77778 citations. Previous affiliations of Stephen R. Quake include Agency for Science, Technology and Research & Allegheny Health Network.
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Journal ArticleDOI
Correlation of Gene Expression and Genome Mutation in Single B-Cells
TL;DR: In this article, a method was developed to simultaneously measure gene expression profiles and genome mutations in single cells, which revealed correlations reflecting the manner in which information propagates between a B-cell's antigen receptors, its gene expression, and its mutagenic machinery.
Journal ArticleDOI
Taxonomic and functional diversity provides insight into microbial pathways and stress responses in the saline Qinghai Lake, China.
Qiuyuan Huang,Qiuyuan Huang,Brandon R. Briggs,Hailiang Dong,Hailiang Dong,Hailiang Dong,Hongchen Jiang,Geng Wu,Christian F. Edwardson,Iwijn De Vlaminck,Stephen R. Quake +10 more
TL;DR: Results indicate a positive relationship between functional diversity and the number of stress response genes, and insight into the stress resilience of microbial metabolic pathways supported by greater taxonomic diversity, which may affect the microbial community response to climate change.
Journal ArticleDOI
High-performance binary protein interaction screening in a microfluidic format.
Matthias Meier,Matthias Meier,Matthias Meier,Rene Sit,Rene Sit,Wenying Pan,Wenying Pan,Stephen R. Quake,Stephen R. Quake +8 more
TL;DR: The presented strategy of reducing the runtime rather than size and volume of the mechanical elements and biological reagent compartments will be of importance for future analytical test systems on microfluidic chips to overcome performance barriers.
Journal ArticleDOI
Sexual and asexual development: two distinct programs producing the same tunicate
Mark Kowarsky,Chiara Anselmi,Chiara Anselmi,Kohji Hotta,Paolo Burighel,Giovanna Zaniolo,Federico Caicci,Benyamin Rosental,Benyamin Rosental,Norma Neff,Katherine J. Ishizuka,Karla J. Palmeri,Jennifer Okamoto,Tal Gordon,Irving L. Weissman,Stephen R. Quake,Lucia Manni,Ayelet Voskoboynik +17 more
TL;DR: In this article, the authors combine transcriptomics and microscopy to build an atlas of the molecular and morphological signatures at each developmental stage for B. schlosseri, and identify hundreds of putative transcription factors with conserved temporal expression.
Proceedings ArticleDOI
An apertureless near field microscope for fluorescence imaging
TL;DR: In this article, an apertureless near-field scanning microscope for fluorescence imaging with λ/20 resolution is presented, where the use of fluorescence allows artifact free imaging and provides a stringent test that the contrast mechanism is optical in origin.