S
Stephen R. Quake
Researcher at Stanford University
Publications - 626
Citations - 89247
Stephen R. Quake is an academic researcher from Stanford University. The author has contributed to research in topics: Transcriptome & Biology. The author has an hindex of 132, co-authored 589 publications receiving 77778 citations. Previous affiliations of Stephen R. Quake include Agency for Science, Technology and Research & Allegheny Health Network.
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Journal ArticleDOI
Correction: Digital PCR provides sensitive and absolute calibration for high throughput sequencing
TL;DR: After this article [1] appeared online, an error was called to the authors' attention that the "universal probe" sequence UPL #149 in Table 6 appears with the 5' and 3' ends reversed.
Posted ContentDOI
Single-cell RNA-seq reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress
Audrey P. Gasch,Feiqiao Brian Yu,James Hose,Leah E. Escalante,Michael Place,Rhonda Bacher,Jad Kanbar,Doina Ciobanu,Laura Sandor,Igor V. Grigoriev,Christina Kendziorski,Stephen R. Quake,Megan N. McClean +12 more
TL;DR: This work used single-cell RNA sequencing to quantify transcript heterogeneity in single S. cerevisiae cells to explore population variation and identify cellular covariates that influence the stress-responsive transcriptome, and uncovered significant regulatory variation in individual yeast cells, both before and after stress.
Journal ArticleDOI
Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets
Jia Zhao,Gefei Wang,Jingsi Ming,Zhixiang Lin,Yan Wang,Snigdha Agarwal,Aditi Agrawal,Ahmad Al-Moujahed,Megan A. Albertelli,Paul Allegakoen,Thomas J Ambrosi,Jane Antony,Steven E. Artandi,Fabienne Aujard,Kyle Awayan,Ankit Baghel,Isaac Bakerman,Trygve E. Bakken,Jalal K Baruni,Philip A. Beachy,Biter Bilen,Olga B. Botvinnik,Scott D. Boyd,Deviana Burhan,Kerriann M. Casey,Charles Chan,Charles B. Chang,Stephen Chang,Ming Chen,Michael F. Clarke,Sheela Crasta,Rebecca N Culver,Jessica D’Addabbo,Spyros Darmanis,Roozbeh Dehghannasiri,Songlin Ding,Connor Duffy,Jacques Epelbaum,F. Hernan Espinoza,Camille Ezran,Jean Farup,James E. Ferrell,Hannah K. Frank,Margaret Fuller,Astrid Gillich,Elias Godoy,Dita Gratzinger,Lisbeth A. Guethlein,Yan Hang,Kazuteru Hasegawa,Rebecca D. Hodge,Malachia Hoover,Franklin W. Huang,Kerwyn Casey Huang,Shelly Huynh,Taichi Isobe,Carly Israel,SoRi Jang,Qiuyu Jing,Robert C. Jones,Jengmin Kang,Caitlin J. Karanewsky,Jim Karkanias,Justus M. Kebschull,Aaron M. Kershner,Lily An Kim,Seung K. Kim,Eliana Kirk,Winston Koh,Silvana Konermann,W. Kong,Mark A. Krasnow,Christin S. Kuo,Corinne Lautier,Song E. Lee,Ed S. Lein,Rebecca Lewis,Peng Li,Shen-yu Lin,Shixuan Liu,Yin Liu,Gabrielle Loeb,Jonathan Z. Long,Wan Jin Lu,Katherine L. Lucot,Liqun Luo,Aaron McGeever,Ross J. Metzger,Thomas J. Montine,Antoine de Morrée,Maurizio Morri,Karim Mrouj,Shravani Mukherjee,Ahmad N. Nabhan,Saba Nafees,Norma F. Neff,Patrick Neuhöfer,Patricia T. Nguyen,Jennifer Okamoto,Julia Eve Olivieri,Youcef Ouadah,H. H. Paine,Peter Parham,Jozeph L. Pendleton,Lolita Penland,Martine Perret,Angela Oliveira Pisco,Zhenzhong Qi,Stephen R. Quake,Ute Radespiel,Thomas A. Rando,Hajanirina N Ravelonjanahary,Andriamahery Razafindrakoto,Julia Salzman,Nicholas Schaum,Robert L. Schopler,Bronwyn Scott,Liza J. Shapiro,Hosu Sin,Rahul P. Sinha,Rene Sit,Geoff Stanley,Lubert Stryer,Varun R. Subramaniam,Aditi Swarup,Weilun Tan,Alexander J. Tarashansky,Aris Taychameekiatchai,Jérémy Terrien,Kyle J. Travaglini,Andoni Urtasun,V. Sivakamasundari,Avin Veerakumar,Venkata N. P. Vemuri,Jean-Michel Verdier,Iwijn De Vlaminck,Douglas Vollrath,Bo Wang,Bruce Wang,Michael F. Z. Wang,Sheng Wang,James E. Webber,Hannah N.W. Weinstein,Irving L. Weissman,Amanda L Wiggenhorn,Cathy V. Williams,Patricia A. Wright,Albert Y. Wu,Angela Ruohao Wu,Tony Wyss-Coray,Baoqing Xiang,Jiamei Yan,Jinxurong Yang,Anne D. Yoder,Brian Yu,Andrea R. Yung,Yue Zhang,Zicheng Zhao,Can Yang +158 more
TL;DR: In this paper , a unified framework of adversarial domain translation is proposed to learn harmonized representations of datasets, which achieves better performance for preserving biological variation during integration while achieving the integration of millions of cells, in minutes, with low memory consumption.
Journal ArticleDOI
Clonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia
Max Jan,Thomas M. Snyder,M. Ryan Corces-Zimmerman,Irving L. Weissman,Stephen R. Quake,Ravindra Majeti +5 more
TL;DR: Results show that pre-leukemic HSC reveal the clonal evolution of AML genomes from founder mutations, and it is determined that a clonal progression of mutations occurs in non-leukedic HSC, based on the identification of individual cells containing subsets of these “early” mutations.
Journal ArticleDOI
Biological Large Scale Integration
TL;DR: In this paper, the authors have developed a method of fabricating very small plumbing devices - chips with small channels and valves that manipulate fluids containing biological molecules and cells, instead of the more familiar chips with wires and transistors that manipulate electrons.