S
Stephen R. Quake
Researcher at Stanford University
Publications - 626
Citations - 89247
Stephen R. Quake is an academic researcher from Stanford University. The author has contributed to research in topics: Transcriptome & Biology. The author has an hindex of 132, co-authored 589 publications receiving 77778 citations. Previous affiliations of Stephen R. Quake include Agency for Science, Technology and Research & Allegheny Health Network.
Papers
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Posted ContentDOI
Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA
Francois Collin,Yuhong Ning,Tierney Phillips,Erin McCarthy,Aaron Scott,Christopher K. Ellison,Chin-Jen Ku,Gulfem Guler,Kim Chau,Alan Ashworth,Stephen R. Quake,Samuel Levy +11 more
TL;DR: It is found that 5hmC sites are enriched in a disease and stage specific manner in exons, 3’UTRs and transcription termination sites with progressive disease suggesting increased transcriptional activity.
Patent
Velocity independent analyte characterization
Shulamit Eyal,Stephen R. Quake +1 more
TL;DR: In this paper, a velocity independent flow cytometry system is presented, where apparatuses for determining velocity independent analyte characteristic parameters and methods for using the same are described and discussed.
PatentDOI
Quantification of transplant-derived circulating cell-free DNA in the absence of a donor genotype
Iwijn De Vlaminck,Eilon Sharon,Jonathan K. Pritchard,Jonathan K. Pritchard,Stephen R. Quake,Hannah A. Valantine,Kiran K. Khush +6 more
TL;DR: This work develops an algorithm that estimates dd-cfDNA levels in the absence of a donor genotype and predicts heart and lung allograft rejection with an accuracy that is similar to conventional GTD, and refined the algorithm to handle closely related recipients and donors.
Posted ContentDOI
5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages
Chun-Xiao Song,Senlin Yin,Li Ma,Amanda Wheeler,Yu Chen,Yan Zhang,Bin Liu,Junjie Xiong,Wei-Han Zhang,Jiankun Hi,Zongguang Zhou,Biao Dong,Zhiqi Tian,Stefanie S. Jeffrey,Mei-Sze Chua,Samuel So,Weimin Li,Yuquan Wei,Jiajie Diao,Dan Xie,Stephen R. Quake +20 more
TL;DR: It is discovered that lung cancer leads to a progressive global loss of 5hmC in cfDNA, whereas hepatocellular carcinoma and pancreatic cancer lead to disease-specific changes in the cell-free hydroxymethylome.
Journal ArticleDOI
Multiplexed locus-specific analysis of DNA methylation in single cells
Lih Feng Cheow,Stephen R. Quake,Stephen R. Quake,William F. Burkholder,Daniel M. Messerschmidt +4 more
TL;DR: The SCRAM method can reliably and accurately detect the methylation status of multiple target sites in each single cell, and it can be completed in a relatively short time (<2 d) at low cost.