S
Stephen R. Quake
Researcher at Stanford University
Publications - 626
Citations - 89247
Stephen R. Quake is an academic researcher from Stanford University. The author has contributed to research in topics: Transcriptome & Biology. The author has an hindex of 132, co-authored 589 publications receiving 77778 citations. Previous affiliations of Stephen R. Quake include Agency for Science, Technology and Research & Allegheny Health Network.
Papers
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Journal ArticleDOI
RNA profiles reveal signatures of future health and disease in pregnancy
Morten Rasmussen,Mitsu Reddy,Rory J. Nolan,Joan Camunas-Soler,Arkady B. Khodursky,Nikolai Madrid Scheller,David E. Cantonwine,Line Engelbrechtsen,Jia Dai Mi,Arup Dutta,Tiffany Brundage,Farooq Siddiqui,Mainou Thao,Elaine P.S. Gee,Johnny La,Courtney Baruch-Gravett,Mark K. Santillan,Saikat Deb,Shaali M. Ame,Said M. Ali,Melanie Adkins,Mark A. DePristo,Manfred Lee,Eugeni Namsaraev,D. Gybel-Brask,Lillian Skibsted,James A. Litch,Donna A. Santillan,Sunil Sazawal,Rachel M. Tribe,James M. Roberts,Maneesh Jain,Estrid Høgdall,Claudia Holzman,Stephen R. Quake,Michal A. Elovitz,Thomas F. McElrath +36 more
TL;DR: In this paper , the ability of plasma cell-free RNA (cfRNA) to reveal patterns of normal pregnancy progression and determine the risk of developing pre-eclampsia months before clinical presentation was demonstrated.
Journal ArticleDOI
Systematic reconstruction of RNA functional motifs with high-throughput microfluidics
Lance Martin,Matthias Meier,Matthias Meier,Matthias Meier,Shawn M. Lyons,Rene Sit,Rene Sit,William F. Marzluff,Stephen R. Quake,Stephen R. Quake,Howard Y. Chang,Howard Y. Chang +11 more
TL;DR: The functional motif reconstructed in a single experiment on the RNA-MITOMI platform uncovers new binding specificities and enriches interpretation of phylogenetic data.
Patent
Simultaneous determination of aneuploidy and fetal fraction
TL;DR: In this paper, the authors present compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained form a pregnant female.
Journal ArticleDOI
Noninvasive Prenatal Diagnosis of Single-Gene Disorders by Use of Droplet Digital PCR
Joan Camunas-Soler,Hojae Lee,Louanne Hudgins,Susan R. Hintz,Yair J. Blumenfeld,Yasser Y. El-Sayed,Stephen R. Quake +6 more
TL;DR: The authors' method detects single-nucleotide mutations of autosomal recessive diseases as early as the first trimester of pregnancy, of importance for metabolic disorders in which early diagnosis can affect management of the disease and reduce complications and anxiety related to invasive testing.
Patent
Microfluidic sample separation device
TL;DR: In this article, a microfluidic chromatography device for separating an analyte from a sample solution, and methods for producing and using the same are described, and a flow channel comprises a chromatography column portion having a solid stationary phase which is capable of separating at least a portion of the analyte and sample solution.