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Stephen R. Quake

Researcher at Stanford University

Publications -  626
Citations -  89247

Stephen R. Quake is an academic researcher from Stanford University. The author has contributed to research in topics: Transcriptome & Biology. The author has an hindex of 132, co-authored 589 publications receiving 77778 citations. Previous affiliations of Stephen R. Quake include Agency for Science, Technology and Research & Allegheny Health Network.

Papers
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Journal ArticleDOI

Memory B Cell Activation, Broad Anti-influenza Antibodies, and Bystander Activation Revealed by Single-Cell Transcriptomics

Felix Horns, +2 more
- 21 Jan 2020 - 
TL;DR: Many antibody clones elicited by vaccination do not bind vaccine, demonstrating non-specific activation of bystander antibodies by influenza vaccination, and offers insight into how molecular recognition, transcriptional programs, and clonal proliferation are coordinated in the human B cell repertoire during memory recall.
Journal ArticleDOI

Hydrogenotrophic methanogenesis in archaeal phylum Verstraetearchaeota reveals the shared ancestry of all methanogens

Bojk A. Berghuis, +6 more
- 27 Feb 2019 - 
TL;DR: The discovery of a complete and divergent hydrogenotrophic methanogenesis pathway in a thermophilic order of the Verstraetearchaeota is reported, which is named Candidatus Methanohydrogenales, as well as the presence of the WLP in the crenarchaeal order Desulfurococcales.
Journal ArticleDOI

Determinism and stochasticity during maturation of the zebrafish antibody repertoire

Ning Jiang, +5 more
- 29 Mar 2011 - 
TL;DR: It is found that the immune system begins in a highly stereotyped state with preferential use of a small number of V (variable) D (diverse) J (joining) gene segment combinations, but that this stereotypy decreases dramatically as the zebrafish mature, with many of the top VDJ combinations observed in 2-wk-old zebra fish virtually disappearing by 1 mo.
Patent

Methods and Systems for Molecular Fingerprinting

Stephen R. Quake, +1 more
TL;DR: In this article, a microfabricated device was proposed to detect the signal of an optically-detectable (e.g., fluorescent) reporter associated with the polynucleotide fragments.
Patent

Solid immersion lens structures and methods for producing solid immersion lens structures

Olivier Legrand, +1 more
TL;DR: A microlens structure such as a solid immersion lens structure is a radiation transmissive pliant elastomer cast to a desired shape and smoothness as mentioned in this paper, such as General Electric RTV 615.