S
Stephen R. Quake
Researcher at Stanford University
Publications - 626
Citations - 89247
Stephen R. Quake is an academic researcher from Stanford University. The author has contributed to research in topics: Transcriptome & Biology. The author has an hindex of 132, co-authored 589 publications receiving 77778 citations. Previous affiliations of Stephen R. Quake include Agency for Science, Technology and Research & Allegheny Health Network.
Papers
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Proceedings ArticleDOI
Microfabricated devices for sizing DNA and sorting cells
TL;DR: In this paper, microfabricated devices to size and sort microscopic biological objects, ranging from cells to single molecules of DNA, have been demonstrated using fluorescent excitation and detection.
Journal ArticleDOI
KIT Signaling Promotes Growth of Colon Xenograft Tumors in Mice and Is Up-Regulated in a Subset of Human Colon Cancers.
Evan C. Chen,Taylor A. Karl,Tomer Kalisky,Santosh Gupta,Catherine A. O’Brien,Teri A. Longacre,Matt van de Rijn,Stephen R. Quake,Michael F. Clarke,Michael E. Rothenberg +9 more
TL;DR: Gene expression analysis of single CD44(+) cells indicated that KIT can promote growth via KITLG autocrine and/or paracrine signaling, and patients with KIT-expressing colon tumors can benefit from KIT RTK inhibitors.
Posted ContentDOI
The Tabula Sapiens: a single cell transcriptomic atlas of multiple organs from individual human donors
TL;DR: This article used single cell transcriptomics to create a molecularly defined phenotypic reference of human cell types which spans 24 human tissues and organs, and used this data to characterize cell type specific RNA splicing and how such splicing varies across tissues within an individual.
Journal ArticleDOI
Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution
Racquel Domingo-Gonzalez,Fabio Zanini,Fabio Zanini,Xibing Che,Min Liu,Robert C. Jones,Michael A. Swift,Stephen R. Quake,David N. Cornfield,Cristina M. Alvira +9 more
TL;DR: It is shown that the late embryonic lung is dominated by specialized proliferative macrophages with a surprising physical interaction with the developing vasculature, and an atlas of the murine lung immune compartment during early postnatal development is presented.
Journal ArticleDOI
Multiplexed analysis of protein-ligand interactions by fluorescence anisotropy in a microfluidic platform.
Lih Feng Cheow,Ramya Viswanathan,Chee-Sing Chin,Nancy Jennifer,Robert C. Jones,Ernesto Guccione,Stephen R. Quake,Stephen R. Quake,Stephen R. Quake,William F. Burkholder +9 more
TL;DR: A homogeneous fluorescence anisotropy-based binding assay in an automated microfluidic chip to simultaneously interrogate >2300 pairwise interactions is implemented and demonstrated the utility of this platform in determining the binding affinities between chromatin-regulatory proteins and different post-translationally modified histone peptides.