Stephen R. Quake

TL;DR: Virus-inclusive single-cell RNA-Seq is a powerful approach to quantitatively assess the complex interplay between virus and host at the single cell level and at a genome-wide scale, and to elucidate the cellular pathways involved in viral infection.

TL;DR: In this article, the authors used single cell RNA sequencing of hippocampal BECs to find correlations between upregulated surface receptors on aging capillaries and the level of their ligands in aging mouse plasma, which suggests that the transcriptional age of BEC is exquisitely sensitive to age-related circulatory cues and pinpoint the BBB itself as a promising therapeutic target to treat brain disease.

TL;DR: In this paper, an implantable pressure sensor based on microfluidic principles is presented, which has a 1 mmHg limit of detection, high sensitivity and excellent reproducibility.

TL;DR: In this article, the authors proposed a method for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample, and characterizing the tissue as abnormal if a difference is detected.

TL;DR: It is found that partial agonistic diabodies preserved the stem-like properties of cultured HSCs, but also blocked oncogenic colony formation in Essential Thrombocythemia (ET) through inverse agonism.