S
Steve P Jackson
Researcher at deCODE genetics
Publications - 2
Citations - 266
Steve P Jackson is an academic researcher from deCODE genetics. The author has contributed to research in topics: Genome-wide association study & Genetic predisposition. The author has an hindex of 2, co-authored 2 publications receiving 155 citations. Previous affiliations of Steve P Jackson include University of Cambridge & University of Iceland.
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Genetic predisposition to mosaic Y chromosome loss in blood.
Deborah J. Thompson,Giulio Genovese,Giulio Genovese,Jonatan Halvardson,Jacob C. Ulirsch,Jacob C. Ulirsch,Daniel J Wright,Daniel J Wright,Chikashi Terao,Olafur B. Davidsson,Felix R. Day,Felix R. Day,Patrick Sulem,Yunxuan Jiang,Marcus Danielsson,Hanna Davies,Joe Dennis,Malcolm G. Dunlop,Douglas F. Easton,Victoria A Fisher,Florian Zink,Richard S. Houlston,Martin Ingelsson,Siddhartha Kar,Nicola D. Kerrison,Ben Kinnersley,Ragnar P. Kristjansson,Philip J. Law,Rong Li,Chey Loveday,Jonas Mattisson,Steven A. McCarroll,Steven A. McCarroll,Yoshinori Murakami,Anna Murray,Paweł Olszewski,Edyta Rychlicka-Buniowska,Edyta Rychlicka-Buniowska,Robert A. Scott,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Ian Tomlinson,Behrooz Torabi Moghadam,Clare Turnbull,Clare Turnbull,Nicholas J. Wareham,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Yoichiro Kamatani,Eva Hoffmann,Steve P Jackson,Steve P Jackson,Kari Stefansson,Adam Auton,Ken K. Ong,Mitchell J. Machiela,Mitchell J. Machiela,Po-Ru Loh,Po-Ru Loh,Jan P. Dumanski,Stephen J. Chanock,Stephen J. Chanock,Lars Forsberg,Lars Forsberg,John R. B. Perry,John R. B. Perry +65 more
TL;DR: A genome-wide association study of mosaic loss of chromosome Y in UK Biobank participants identifies 156 genetic determinants of LOY, showing that LOY is associated with cancer and non-haematological health outcomes and supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in other tissues.
Journal ArticleDOI
Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility
Daniel J Wright,Felix R. Day,Nicola D. Kerrison,Florian Zink,Alexia Cardona,Patrick Sulem,Deborah J. Thompson,Svanhvit Sigurjonsdottir,Daniel F. Gudbjartsson,Agnar Helgason,J. Ross Chapman,Steve P Jackson,Claudia Langenberg,Nicholas J. Wareham,Robert A. Scott,Unnur Thorsteindottir,Unnur Thorsteindottir,Ken K. Ong,Kari Stefansson,Kari Stefansson,John R. B. Perry +20 more
TL;DR: The results demonstrate that genotype-array-intensity data enables a measure of cell cycle efficiency at population scale and identifies genes implicated in aneuploidy, genome instability and cancer susceptibility, in addition to inferring a causal effect of smoking on mLOY.