J
Jonas Mattisson
Researcher at Science for Life Laboratory
Publications - 14
Citations - 380
Jonas Mattisson is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Cancer & Immunology. The author has an hindex of 7, co-authored 11 publications receiving 169 citations.
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Journal ArticleDOI
Genetic predisposition to mosaic Y chromosome loss in blood.
Deborah J. Thompson,Giulio Genovese,Giulio Genovese,Jonatan Halvardson,Jacob C. Ulirsch,Jacob C. Ulirsch,Daniel J Wright,Daniel J Wright,Chikashi Terao,Olafur B. Davidsson,Felix R. Day,Felix R. Day,Patrick Sulem,Yunxuan Jiang,Marcus Danielsson,Hanna Davies,Joe Dennis,Malcolm G. Dunlop,Douglas F. Easton,Victoria A Fisher,Florian Zink,Richard S. Houlston,Martin Ingelsson,Siddhartha Kar,Nicola D. Kerrison,Ben Kinnersley,Ragnar P. Kristjansson,Philip J. Law,Rong Li,Chey Loveday,Jonas Mattisson,Steven A. McCarroll,Steven A. McCarroll,Yoshinori Murakami,Anna Murray,Paweł Olszewski,Edyta Rychlicka-Buniowska,Edyta Rychlicka-Buniowska,Robert A. Scott,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Ian Tomlinson,Behrooz Torabi Moghadam,Clare Turnbull,Clare Turnbull,Nicholas J. Wareham,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Yoichiro Kamatani,Eva Hoffmann,Steve P Jackson,Steve P Jackson,Kari Stefansson,Adam Auton,Ken K. Ong,Mitchell J. Machiela,Mitchell J. Machiela,Po-Ru Loh,Po-Ru Loh,Jan P. Dumanski,Stephen J. Chanock,Stephen J. Chanock,Lars Forsberg,Lars Forsberg,John R. B. Perry,John R. B. Perry +65 more
TL;DR: A genome-wide association study of mosaic loss of chromosome Y in UK Biobank participants identifies 156 genetic determinants of LOY, showing that LOY is associated with cancer and non-haematological health outcomes and supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in other tissues.
Journal ArticleDOI
Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
Marcus Danielsson,Jonatan Halvardson,Hanna Davies,Behrooz Torabi Moghadam,Jonas Mattisson,Edyta Rychlicka-Buniowska,Edyta Rychlicka-Buniowska,Janusz Jaszczyński,Julia Heintz,Lars Lannfelt,Vilmantas Giedraitis,Martin Ingelsson,Jan P. Dumanski,Jan P. Dumanski,Lars Forsberg,Lars Forsberg +15 more
TL;DR: A formula to transform mLRRY-values to percentage of LOY that is a more comprehensible unit is presented and could be applied for analyses of the vast amount of SNP-array data already generated in the scientific community, allowing further discoveries of LOy associated diseases and outcomes.
Journal ArticleDOI
Mosaic loss of chromosome Y in leukocytes matters
Lars Forsberg,Lars Forsberg,Jonatan Halvardson,Edyta Rychlicka-Buniowska,Marcus Danielsson,Behrooz Torabi Moghadam,Jonas Mattisson,Chiara Rasi,Hanna Davies,Lars Lind,Vilmantas Giedraitis,Lars Lannfelt,Lena Kilander,Martin Ingelsson,Jan P. Dumanski,Jan P. Dumanski +15 more
TL;DR: The presented analysis clarifies the utility and limits of the deterministic approximation; details the effect of this assumption on the authors' gene-specific estimates of heterozygous selection coefficients; and reiterates the practical utility of selection estimates in human genetics.
Journal ArticleDOI
Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
Jan P. Dumanski,Jan P. Dumanski,Jonatan Halvardson,Hanna Davies,Edyta Rychlicka-Buniowska,Jonas Mattisson,Behrooz Torabi Moghadam,Noémi Nagy,Kazimierz Weglarczyk,Karolina Bukowska-Strakova,Marcus Danielsson,Paweł Olszewski,Arkadiusz Piotrowski,Erin Oerton,Aleksandra Ambicka,Marcin Przewoźnik,Łukasz Bełch,Tomasz Grodzicki,Piotr Chlosta,Stefan Imreh,Vilmantas Giedraitis,Lena Kilander,Jessica Nordlund,Adam Ameur,Ulf Gyllensten,Åsa Johansson,Alicja Jozkowicz,Maciej Siedlar,Alicja Klich-Rączka,Janusz Jaszczyński,Stefan Enroth,Jarosław Baran,Martin Ingelsson,John R. B. Perry,Janusz Ryś,Lars Forsberg,Lars Forsberg +36 more
TL;DR: In this article, DNA and RNA from leukocytes in sorted-and single-cells in vivo and in vitro were analyzed to study the effect of chromosome Y mosaicism on leukocyte gene expression.
Journal ArticleDOI
Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality
Soichi Sano,Keita Horitani,Hayato Ogawa,Jonatan Halvardson,Nicholas W. Chavkin,Ying Wang,Miho Sano,Jonas Mattisson,Atsushi Hata,Marcus Danielsson,Emiri Miura-Yura,Ammar Zaghlool,Megan A Evans,Tove Fall,Henry N. De Hoyos,Johan Sundström,Yoshimitsu Yura,Anupreet Kour,Yohei Arai,Mark C. Thel,Yuka Arai,Josyf C. Mychaleckyj,Karen K. Hirschi,Lars Forsberg,K. Walsh +24 more
TL;DR: Results indicate that hematopoietic mLOY causally contributes to fibrosis, cardiac dysfunction, and mortality in men.