Stijn Michielse

TL;DR: WM of the prefrontal region was the most vulnerable to aging, while temporal lobe connections, cingulum, and parieto-occipital commissural connections showed relative preservation with age.

TL;DR: Results show that even when given the exact same sets of underlying streamlines, the variability across protocols for bundle segmentation is greater than all other sources of variability in the virtual dissection process, including variability within protocols and variability across subjects.

TL;DR: Despite shared genetic liability, first-degree relatives of patients with schizophrenia and bipolar disorder show a differential pattern of structural brain abnormalities, specifically a divergent effect in ICV, which may imply that the neurodevelopmental trajectories leading to brain anomalies in schizophrenia or bipolar disorder are distinct.

TL;DR: Novel experimental evidence is provided that pattern separation is related to generalization of threat expectancies, and reduced fear inhibition processes in frontal regions, and therefore may contribute to the pathophysiology of anxiety disorders and PTSD.

TL;DR: Striatal RPE signals are disrupted along the depression continuum, suggesting that real-life coupling of reward anticipation and engagement in rewarding activities might be a relevant target of psychological therapies for depression.