S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
Papers
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Journal ArticleDOI
Somatic generation of antibody diversity
TL;DR: In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome which are assembled by recombination which leads to the formation of a complete gene.
Journal ArticleDOI
RAG-1-deficient mice have no mature B and T lymphocytes
Peter Mombaerts,John Iacomini,Randall S. Johnson,Karl Herrup,Susumu Tonegawa,Virginia E. Papaioannou +5 more
TL;DR: The introduction of a mutation in RAG-1 into the germline of mice via gene targeting in embryonic stem cells is described and it is shown that this mutation either activates or catalyzes the V(D)J recombination reaction of immunoglobulin and T cell receptor genes.
Journal ArticleDOI
The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory
TL;DR: The results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories.
Book ChapterDOI
Somatic Generation of Antibody Diversity1
TL;DR: In this paper, it was shown that an organism does not inherit even a single complete gene for antibody polypeptide chains, rather, the genetic information is transmitted in germline as no more than several hundred gene segments.
Journal ArticleDOI
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Alcino J. Silva,Alcino J. Silva,Charles F. Stevens,Charles F. Stevens,Susumu Tonegawa,Susumu Tonegawa,Yanyan Wang,Yanyan Wang +7 more
TL;DR: W Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact and are therefore a suitable model for studying the relation between LTP and learning processes.